This application proposes to continue the Postdoctoral Training Program in Research on Abused Drugs established at the New York University School of Medicine in 1992. A group of ten senior faculty members, with research programs in the study of drugs of abuse and related mechanisms, serve as preceptorsof trainees and conduct a didactic program tailored to meet individual needs. Preceptor research is supported by 21 active NIH grants, many of which are related to drug abuse. The Training Program emphasizes laboratory research with regularly scheduled seminars featuring distinguished drug abuse investigators from other Institutions, and a """"""""works-in progress"""""""" series in which trainees and preceptors have the opportunity to present and critically discuss ongoing research. The didactic component of the Program includes courses at the School of Medicine and Center for Neural Science. In addition, trainees attend Grand Rounds of the Division of Alcoholism and Drug Abuse, Psychiatry Grand Rounds, and the Neuroscience Colloquia. A Training Committee establishes training goals for each trainee and monitors progress in research, publication, and post-training career planning. An ExternalAdvisory Board, consisting of three leaders in the drug abuse field, site-visit the Program annually to evaluate and advise with regard to Program characteristics and trainee progress. Program development and training success during the third project period have been excellent. The Program has had a significant effect on drug abuse research and training at NYU School of Medicine and is a key component of the Clinical and ResearchTraining Coreof the newly established Center of Excellenceon Addiction.The Program has had no difficulty attracting applicants. During the third project period, over 50candidates applied and 8 were selected for training. A high priority has been placed on recruiting women and minority candidates. In summary, the Postdoctoral Training Program in Research on Abused Drugs represents a valuable opportunity for young scientists to obtain multidisciplinary training, in New York City, in the neuroscience of drug abuse and develop into independent investigators with a commitment to drug abuse research.

Public Health Relevance

The main goal of this program is to train the next generation of addiction specialists who will have a broad understanding of the addiction field and the skills and commitment to conduct basic and translational research leading to a greater understanding of the neurobiology of addiction and development of new treatments.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Institutional National Research Service Award (T32)
Project #
5T32DA007254-20
Application #
8464036
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Babecki, Beth
Project Start
1991-09-30
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
20
Fiscal Year
2013
Total Cost
$226,126
Indirect Cost
$16,750
Name
New York University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
Pick, Joseph E; Ziff, Edward B (2018) Regulation of AMPA receptor trafficking and exit from the endoplasmic reticulum. Mol Cell Neurosci 91:3-9
Pick, Joseph E; Khatri, Latika; Sathler, Matheus F et al. (2017) mGluR long-term depression regulates GluA2 association with COPII vesicles and exit from the endoplasmic reticulum. EMBO J 36:232-244
O'Neill, Brian; Patel, Jyoti C; Rice, Margaret E (2017) Characterization of Optically and Electrically Evoked Dopamine Release in Striatal Slices from Digenic Knock-in Mice with DAT-Driven Expression of Channelrhodopsin. ACS Chem Neurosci 8:310-319
Kuchibhotla, Kishore V; Gill, Jonathan V; Lindsay, Grace W et al. (2017) Parallel processing by cortical inhibition enables context-dependent behavior. Nat Neurosci 20:62-71
Kim, Seonil; Pick, Joseph E; Abera, Sinedu et al. (2016) Brain region-specific effects of cGMP-dependent kinase II knockout on AMPA receptor trafficking and animal behavior. Learn Mem 23:435-41
O'Neill, Brian; Lauterstein, Dana; Patel, Jyoti C et al. (2015) Striatal dopamine release regulation by the cholinergic properties of the smokeless tobacco, gutkha. ACS Chem Neurosci 6:832-7
Lee, Christian R; Patel, Jyoti C; O'Neill, Brian et al. (2015) Inhibitory and excitatory neuromodulation by hydrogen peroxide: translating energetics to information. J Physiol 593:3431-46
Peng, X-X; Lister, A; Rabinowitsch, A et al. (2015) Episodic sucrose intake during food restriction increases synaptic abundance of AMPA receptors in nucleus accumbens and augments intake of sucrose following restoration of ad libitum feeding. Neuroscience 295:58-71
Peng, Xing-Xiang; Cabeza de Vaca, Soledad; Ziff, Edward B et al. (2014) Involvement of nucleus accumbens AMPA receptor trafficking in augmentation of D- amphetamine reward in food-restricted rats. Psychopharmacology (Berl) 231:3055-63
Ha, Jenny; Cohen, Jessica I; Tirsi, Aziz et al. (2013) Association of obesity-mediated insulin resistance and hypothalamic volumes: possible sex differences. Dis Markers 35:249-59

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