The overall purpose of this training grant is to provide postdoctoral training to young basic scientists and physicians in the area of neurobiology of substance abuse, with a focus on the mode of action of psychostimulant and opiate drugs at the genetic, molecular, circuit and behavioral levels. Our objective is to provide an exciting and innovative environment with world class facilities and faculty to develop the next generation of scientists working in drug abuse. Training will take place in the multidisciplinary setting at the University of Michigan. The 15 faculty are all NIDA grantees (or Co-Investigators) and have expertise in the neurobiology of substance abuse, with particular emphasis on the area of opioid and psychostimulant drugs. The focus of the proposal is the training of Ph.D. and M.D. postdoctoral fellows in state-of-the-art approaches for studying mechanisms underlying abuse of psychoactive drugs. This includes studying the genetic, developmental and environmental factors that lead to vulnerability to substance abuse: the mode of action of drugs of abuse at the molecular, cellular, anatomical and behavioral levels; and the long-term consequences of psychoactive drugs on the brain, as mediated through mechanisms of neural plasticity. The working assumption is that the functional and structural brain remodeling associated with chronic drug use lies at the basis of tolerance, sensitization, physical dependence, and psychological addiction to these drugs. The drug abuse research community at the University of Michigan is of high quality and has a long history in the field. Beyond their individual strengths, the training faculty members have long-term scientific and training relationships with each other. These historical strengths have recently been significantly enhanced with a number of initiatives at the University of Michigan, designed to facilitate life science research in general, and neuroscience research in particular. They include state-of-the-art tools for mouse and rat genetics, genomics, proteomics, and informatics. Thus, our trainees will profit from a highly sophisticated, yet supportive, research and training environment. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Institutional National Research Service Award (T32)
Project #
2T32DA007268-16
Application #
7233767
Study Section
Special Emphasis Panel (ZDA1-MXS-M (20))
Program Officer
Avila, Albert
Project Start
1991-09-30
Project End
2012-06-30
Budget Start
2007-07-10
Budget End
2008-06-30
Support Year
16
Fiscal Year
2007
Total Cost
$273,968
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Pharmacology
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Ahrens, Allison M; Ferguson, Lindsay M; Robinson, Terry E et al. (2018) Dynamic Encoding of Incentive Salience in the Ventral Pallidum: Dependence on the Form of the Reward Cue. eNeuro 5:
Kandasamy, Ram; Dawson, Cole T; Craft, Rebecca M et al. (2018) Anti-migraine effect of ?9-tetrahydrocannabinol in the female rat. Eur J Pharmacol 818:271-277
Kandasamy, Ram; Dawson, Cole T; Hilgendorf, Tammy N et al. (2018) Medication overuse headache following repeated morphine, but not [INCREMENT]9-tetrahydrocannabinol administration in the female rat. Behav Pharmacol 29:469-472
Zestos, Alexander G; Carpenter, Colleen; Kim, Youngsoo et al. (2018) Ruboxistaurin Reduces Cocaine-Stimulated Increases in Extracellular Dopamine by Modifying Dopamine-Autoreceptor Activity. ACS Chem Neurosci :
Olney, Jeffrey J; Warlow, Shelley M; Naffziger, Erin E et al. (2018) Current perspectives on incentive salience and applications to clinical disorders. Curr Opin Behav Sci 22:59-69
Singer, Bryan F; Fadanelli, Monica; Kawa, Alex B et al. (2018) Are Cocaine-Seeking ""Habits"" Necessary for the Development of Addiction-Like Behavior in Rats? J Neurosci 38:60-73
Kuhn, Brittany N; Klumpner, Marin S; Covelo, Ignacio R et al. (2018) Transient inactivation of the paraventricular nucleus of the thalamus enhances cue-induced reinstatement in goal-trackers, but not sign-trackers. Psychopharmacology (Berl) 235:999-1014
Jun, Heejin; Yu, Hui; Gong, Jianke et al. (2018) An immune-beige adipocyte communication via nicotinic acetylcholine receptor signaling. Nat Med 24:814-822
Trucco, Elisa M; Cope, Lora M; Burmeister, Margit et al. (2018) Pathways to Youth Behavior: The Role of Genetic, Neural, and Behavioral Markers. J Res Adolesc 28:26-39
Song, Zhimin; Kalyani, Manu; Becker, Jill B (2018) Sex differences in motivated behaviors in animal models. Curr Opin Behav Sci 23:98-102

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