This proposal will establish a unique training program in an emerging area-translational research in addiction. This field has a diverse set of disciplinary perspectives, procedures, paradigms, and technologies to measure or alter processes affecting development, maintenance, and cessation of drug dependence in humans. Scientists trained in translational research will be at the crossroads of basic and clinical research, where they can provide a crucial pathway between these two domains. Trainee research opportunities will include, among many others, laboratory studies of antibody-based therapy for methamphetamine abuse, studies of the behavioral economics of addiction, novel medications to treat cocaine and opiate dependence, behavioral treatments of marijuana dependence, behavioral and neural mechanisms of change, treatment service dissemination, and cost- effectiveness of reducing drug treatment barriers. The project will train addiction scientists to participate in translational science that directly assesses the clinical relevance of basic research;conducts scientific analyses of basic processes underlying drug abuse;helps develop and assess behavioral and pharmacological treatments of addiction;determines approaches to integrate these findings into clinical practice;and identifies policies that support integration. This program will be greatly enhanced by the prior training success of the program's 12 core faculty, who are MDs or PhDs with appointments in Pharmacology and Toxicology, Psychiatry, and Health Behavior and Health Promotion departments and have 22 NIDA, 3 N1AA, 1 N1CHD, 1 SAMSHA, 1 NIMH, and 16 VA research grants. Among the 28 predoctoral and 37 postdoctoral students trained by these core faculty, 86% of the predoctoral and 89% of postdoctoral students are still involved in research/academics and 49% of postdoctoral trainees have faculty positions. Collectively, trainees authored more than 500 publications were first author on 40% of them, and obtained 43 research grants. The new program proposed here will train, through stepped increases in enrollment, a total of 5 predoctorals, 7 postdoctorals, and 19 medical students by the end of the grant cycle. Trainee selection will be based on scholastic excellence and commitment to addiction research careers. Training will take place at the Center for Addiction Research.

Public Health Relevance

This proposed training program is relevant to the public health because it will train new scientists at the pre and post doctoral level to conduct translational research into addictions and its treatment.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Institutional National Research Service Award (T32)
Project #
5T32DA022981-04
Application #
8287686
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Aklin, Will
Project Start
2009-07-01
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
4
Fiscal Year
2012
Total Cost
$350,671
Indirect Cost
$24,853
Name
University of Arkansas for Medical Sciences
Department
Psychiatry
Type
Schools of Medicine
DUNS #
122452563
City
Little Rock
State
AR
Country
United States
Zip Code
72205
Bush, Keith A; Privratsky, Anthony; Gardner, Jonathan et al. (2018) Common Functional Brain States Encode both Perceived Emotion and the Psychophysiological Response to Affective Stimuli. Sci Rep 8:15444
Hayes, Corey J; Li, Xiaocong; Li, Chenghui et al. (2018) Health-Related Quality of Life among Chronic Opioid Users, Nonchronic Opioid Users, and Nonopioid Users with Chronic Noncancer Pain. Health Serv Res 53:3329-3349
Coker, Jessica L; Catlin, David; Ray-Griffith, Shona et al. (2018) Buprenorphine medication-assisted treatment during pregnancy: An exploratory factor analysis associated with adherence. Drug Alcohol Depend 192:146-149
Berquist, Michael D; Hyatt, William S; Bauer-Erickson, Jonathan et al. (2018) Phencyclidine-like in vivo effects of methoxetamine in mice and rats. Neuropharmacology 134:158-166
Gannon, Brenda M; Williamson, Adrian; Rice, Kenner C et al. (2018) Role of monoaminergic systems and ambient temperature in bath salts constituent 3,4-methylenedioxypyrovalerone (MDPV)-elicited hyperthermia and locomotor stimulation in mice. Neuropharmacology 134:13-21
Zielinski, Melissa J; Veilleux, Jennifer C (2018) The Perceived Invalidation of Emotion Scale (PIES): Development and psychometric properties of a novel measure of current emotion invalidation. Psychol Assess 30:1454-1467
Bush, Keith A; Gardner, Jonathan; Privratsky, Anthony et al. (2018) Brain States That Encode Perceived Emotion Are Reproducible but Their Classification Accuracy Is Stimulus-Dependent. Front Hum Neurosci 12:262
Zielinski, Melissa J; Privratsky, Anthony A; Smitherman, Sonet et al. (2018) Does development moderate the effect of early life assaultive violence on resting-state networks? An exploratory study. Psychiatry Res Neuroimaging 281:69-77
Martins, Bradford S; Cáceda, Ricardo; Cisler, Josh M et al. (2018) The neural representation of the association between comorbid drug use disorders and childhood maltreatment. Drug Alcohol Depend 192:215-222
Chung, Ming-Hua; Martins, Bradford; Privratsky, Anthony et al. (2018) Individual differences in rate of acquiring stable neural representations of tasks in fMRI. PLoS One 13:e0207352

Showing the most recent 10 out of 77 publications