This application is submitted to support the Comprehensive Research Training Program for Oral Health Scientists in response to the NIDCR Program Announcement 00-116. This program will provide research training for well-qualified candidates to prepare them to be leading oral health research faculty in the nation's dental schools and oral health research institutions. A novel feature of the program takes advantage of the recent establishment of The Buffalo Center of Excellence in Bioinformatics. This Center will merge super-computing and visualization technology with expertise in genomics, proteomics, and bioimaging to foster advances in biomedical sciences and health care. Trainees will interact with the Center formally (by requiring bioinformatics course work and by regularly inviting Center faculty to give seminars) and informally (by encouraging collaboration with Center investigators) to enhance bioinformatics approaches in their research projects. The program will be composed of four tracks: 1) The PhD degree track will provide state-of-the-art research training in Oral Biology or in other related disciplines. Students who matriculate in the PhD program may do so at the post-BS, or post-DDS, levels. The PhD/Clinical Residency track will allow DDS trainees to combine PhD training with certificate-level training in one of five clinical dental specialties including endodontics, oral pathology, orthodontics, periodontology, or prosthodontics; 2) The combined DDS/PhD degree track (DSTP) will provide an integrated, dental and graduate research-training program for students to earn both the DDS and PhD degrees; 3) The non-degree postdoctoral research track will provide in-depth experience for trainees to engage in original research that builds upon their doctoral level training; and 4) The short-term track will provide training for a) students enrolled in the DDS program; and b) clinical faculty members to obtain additional training in basic science or clinical research. We provide evidence of enthusiastic and substantial institutional support for trainees after NIH funding ceases. Efforts have been made to acquire additional streams for recruitment of minority trainees into the program. The requested number of trainee slots has been reduced to be consonant with realistic recruitment targets. The proposal also responds to a number of other concerns stated in the previous review. We believe this proposal is sufficiently improved so as to allow continuation of a long-standing and successful oral health research training program. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Institutional National Research Service Award (T32)
Project #
5T32DE007034-28
Application #
6784204
Study Section
Special Emphasis Panel (ZDE1-LK (25))
Program Officer
Hardwick, Kevin S
Project Start
1975-07-01
Project End
2008-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
28
Fiscal Year
2004
Total Cost
$743,997
Indirect Cost
Name
State University of New York at Buffalo
Department
Dentistry
Type
Schools of Dentistry
DUNS #
038633251
City
Buffalo
State
NY
Country
United States
Zip Code
14260
Tezal, Mine; Scannapieco, Frank A; Wactawski-Wende, Jean et al. (2013) Dental caries and head and neck cancers. JAMA Otolaryngol Head Neck Surg 139:1054-60
Tezal, Mine; Scannapieco, Frank A; Wactawski-Wende, Jean et al. (2012) Local inflammation and human papillomavirus status of head and neck cancers. Arch Otolaryngol Head Neck Surg 138:669-75
Nikitkova, A E; Haase, E M; Scannapieco, F A (2012) Effect of starch and amylase on the expression of amylase-binding protein A in Streptococcus gordonii. Mol Oral Microbiol 27:284-94
Conti, H R; Baker, O; Freeman, A F et al. (2011) New mechanism of oral immunity to mucosal candidiasis in hyper-IgE syndrome. Mucosal Immunol 4:448-55
Pandiyan, Pushpa; Conti, Heather R; Zheng, Lixin et al. (2011) CD4(+)CD25(+)Foxp3(+) regulatory T cells promote Th17 cells in vitro and enhance host resistance in mouse Candida albicans Th17 cell infection model. Immunity 34:422-34
Bradford, Peter G; Gerace, Ken V; Roland, Renée L et al. (2010) Estrogen regulation of apoptosis in osteoblasts. Physiol Behav 99:181-5
Vorrasi, J; Chaudhuri, B; Haase, E M et al. (2010) Identification and characterization of amylase-binding protein C from Streptococcus mitis NS51. Mol Oral Microbiol 25:150-6
Boehm, Tobias Konrad; Sojar, Hakimuddin; Denardin, Ernesto (2010) Concentration-dependent effect of fibrinogen on IgG-specific antigen binding and phagocytosis. Cell Immunol 263:41-8
Gerrish, Robert S; Gill, Ann L; Fowler, Vance G et al. (2010) Development of pooled suppression subtractive hybridization to analyze the pangenome of Staphylococcus aureus. J Microbiol Methods 81:56-60
Conti, Heather R; Gaffen, Sarah L (2010) Host responses to Candida albicans: Th17 cells and mucosal candidiasis. Microbes Infect 12:518-27

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