This proposal is a competitive renewal of an institutional NRSA training grant titled: """"""""Comprehensive Training in Oral and Craniofacial Sciences."""""""" The goal of this program is to integrate ongoing training programs within the Ohio State University Health Sciences Center, under the umbrella of the College of Dentistry, to address the urgent need to train faculty in oral health and craniofacial research. Faculty in the CTOC program recognizes the shortage of qualified research faculty in multidisciplinary research to fill positions in academic dentistry. Over the last 15 years, programs have been developed in the OSU College of Dentistry to train academic clinicians in multidisciplinary research. The DDS/PhD and Clinician Scientist programs were started with funding provided by the College. In time, trainees successfully wrote individual NRSA grants to support their training. In this training environment, faculty in the College of Dentistry, together with faculty in the OSU Health Sciences Center, prepared an institutional NRSA that was funded four years ago. The CTOC program has enriched the training environment for in the College and provides opportunities for: 1) short-term training programs for pre-doctoral students and faculty; 2) predoctoral training in the Oral Biology PhD program and three parallel programs in Integrated Biomedical Sciences, Neuroscience/Psychobiology, and Biomedical Engineering; 3) combined DDS/PhD training; and 4) post doctoral training including post PhDs and Clinician/Scientists; 5) long term research training for faculty. The focus of each of these programs is to develop research experiences that will help to recruit, train, and retain qualified academicians in oral health and craniofacial sciences. We have successfully recruited trainees in each of the training programs mentioned above. Currently, there are 9 DDS/PhD trainees, 5 predoctoral and 3 postdoctoral trainees (including one faculty member), and 6 short-term dental student trainees. A central focus continues to be the recruitment of highly qualified candidates into flexible training programs that will provide them with long-term success. A second focus is to provide training opportunities for junior faculty. The CTOC program provides an innovative multidisciplinary basic science curriculum based on the mechanisms of human disease, a flexible curriculum in the oral sciences that links trainees from various biomedical programs, and a long-term plan to mentor trainees for careers in academic research. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Institutional National Research Service Award (T32)
Project #
5T32DE014320-08
Application #
7458761
Study Section
Special Emphasis Panel (ZDE1-LK (28))
Program Officer
Hardwick, Kevin S
Project Start
2001-08-01
Project End
2011-06-30
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
8
Fiscal Year
2008
Total Cost
$657,694
Indirect Cost
Name
Ohio State University
Department
Dentistry
Type
Schools of Dentistry
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
Weber, Michael D; McKim, Daniel B; Niraula, Anzela et al. (2018) The Influence of Microglial Elimination and Repopulation on Stress Sensitization Induced by Repeated Social Defeat. Biol Psychiatry :
Sawicki, Caroline M; Kim, January K; Weber, Michael D et al. (2018) Ropivacaine and Bupivacaine prevent increased pain sensitivity without altering neuroimmune activation following repeated social defeat stress. Brain Behav Immun 69:113-123
McKim, D B; Weber, M D; Niraula, A et al. (2018) Microglial recruitment of IL-1?-producing monocytes to brain endothelium causes stress-induced anxiety. Mol Psychiatry 23:1421-1431
Mason, Matthew R; Chambers, Stephanie; Dabdoub, Shareef M et al. (2018) Characterizing oral microbial communities across dentition states and colonization niches. Microbiome 6:67
Wilson, Stephanie J; Bailey, Brittney E; Jaremka, Lisa M et al. (2018) When couples' hearts beat together: Synchrony in heart rate variability during conflict predicts heightened inflammation throughout the day. Psychoneuroendocrinology 93:107-116
Witcher, Kristina G; Bray, Chelsea E; Dziabis, Julia E et al. (2018) Traumatic brain injury-induced neuronal damage in the somatosensory cortex causes formation of rod-shaped microglia that promote astrogliosis and persistent neuroinflammation. Glia 66:2719-2736
Kiecolt-Glaser, Janice K; Wilson, Stephanie J; Bailey, Michael L et al. (2018) Marital distress, depression, and a leaky gut: Translocation of bacterial endotoxin as a pathway to inflammation. Psychoneuroendocrinology 98:52-60
Ganesan, Sukirth M; Joshi, Vinayak; Fellows, Megan et al. (2017) A tale of two risks: smoking, diabetes and the subgingival microbiome. ISME J 11:2075-2089
Kiecolt-Glaser, Janice K; Wilson, Stephanie J (2017) Caregiver Vulnerability and Brain Structural Markers: Compounding Risk. Am J Geriatr Psychiatry 25:592-594
Wilson, Stephanie J; Jaremka, Lisa M; Fagundes, Christopher P et al. (2017) Shortened sleep fuels inflammatory responses to marital conflict: Emotion regulation matters. Psychoneuroendocrinology 79:74-83

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