The postdoctoral research training program in Endocrinology and Diabetes at the Massachusetts General Hospital provides intensive research experience in basic or clinical investigation, complemented by a didactic component appropriate to the training goals. The trainees are primarily M.D.'s and M.D./Ph.D.'s who desire a career in investigative endocrinology and academic medicine, as well as Ph.D.'s who want further research training. The trainees are selected from a large applicant pool on the basis of prior academic and/or research achievement and evidence of strong commitment to a career in biomedical investigation. The Program director (J. Avruch) and the Associate Director (J. Florez) are senior and mid-career Physician-Scientists respectively who govern in conjunction with a committee of experienced endocrine scientists (Habener, Kronenberg, Crowley, Freeman, Grinspoon and Klibanski). The faculty consists of 42 active, well-funded scientists, whose interests range broadly across the subdisciplines of endocrinology and from clinical, bedside investigation to molecular mechanisms. The trainees are supervised closely by a primary faculty mentor, and interact extensively with junior faculty, who often serve as secondary mentors. An extensive program of didactic sessions complements the research activity. The training period is 2-4 years but may include several years additional experience at junior faculty status, so as to permit consolidation of skills and maximal competitiveness for independent support. The productivity of past trainees during training has been very high overall, as judged by the number and quality of trainee publications. Twenty seven of 44 program graduates since 2004 supported by this award remain in academia and ten are in the biotechnology/pharmaceutical industry. Among the 27 in academia, 7 have an R01 or equivalent (R21, DP2, U01 site PI), six others have K series award, and three have KL2/Medical Research Investigator Training awards from the Harvard CTSA. The facilities at the MGH are extensive, including an Institutional Clinical Research Support Program and over 50,000 square feet of modern laboratories dedicated to endocrine training faculty. This training grant is the central stabilizing financial element in this program, and is critical in enabling M.D. trainees to achieve careers in biomedical investigation.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007028-45
Application #
9723077
Study Section
Kidney, Urologic and Hematologic Diseases D Subcommittee (DDK)
Program Officer
Castle, Arthur
Project Start
1975-07-01
Project End
2020-06-30
Budget Start
2019-07-01
Budget End
2020-06-30
Support Year
45
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02114
Rosenbaum, Matthew W; Gigliotti, Benjamin J; Pai, Sara I et al. (2018) PD-L1 and IDO1 Are Expressed in Poorly Differentiated Thyroid Carcinoma. Endocr Pathol 29:59-67
Gogia, Shawnbir; Coromilas, Alexandra; Regan, Susan et al. (2018) Cardiovascular Risk Profile of Transgender Women With HIV: A US Health Care Database Study. J Acquir Immune Defic Syndr 79:e39-e41
Cheru, Lediya T; Park, Elli A; Saylor, Charles F et al. (2018) I-FABP Is Higher in People With Chronic HIV Than Elite Controllers, Related to Sugar and Fatty Acid Intake and Inversely Related to Body Fat in People With HIV. Open Forum Infect Dis 5:ofy288
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Cox, Kimberly H; Oliveira, Luciana M B; Plummer, Lacey et al. (2018) Modeling mutant/wild-type interactions to ascertain pathogenicity of PROKR2 missense variants in patients with isolated GnRH deficiency. Hum Mol Genet 27:338-350
Yang, Xuehui; Gong, Yan; He, Qing et al. (2018) Loss of Spry1 attenuates vascular smooth muscle proliferation by impairing mitogen-mediated changes in cell cycle regulatory circuits. J Cell Biochem 119:3267-3279

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