Abstract

This program started over 20 years ago under the leadership of Dr. Sanford B. Kranz, Professor of Medicine and Chief of Medical Hematology at Vanderbilt University. The purpose of the program is to provide postdoctoral research training in hematology for individuals with the M.D. or Ph.D. degree. In the present application, there are 16 participating faculty in the program. Most have primary appointments in the Departments of Medicine or Pathology, but there also are a number of basic science faculty who are interested in collaborative training with hematology group.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007186-23
Application #
2900092
Study Section
Special Emphasis Panel (SRC)
Program Officer
Bishop, Terry Rogers
Project Start
1976-09-27
Project End
2002-03-31
Budget Start
1999-04-01
Budget End
2000-03-31
Support Year
23
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Vanderbilt University Medical Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212

  Publications

Dai, Chunhua; Chung, Ik-Joo; Krantz, Sanford B (2004) In human immature BFU-E tumor necrosis factor-alpha not only downregulates CDK6 but also directly produces apoptosis which is prevented by stem cell factor. Exp Hematol 32:911-7
Chung, Ik-Joo; Dai, Chunhua; Krantz, Sanford B (2003) Stem cell factor increases the expression of FLIP that inhibits IFNgamma -induced apoptosis in human erythroid progenitor cells. Blood 101:1324-8
Anderson, Patricia J; Bock, Paul E (2003) Role of prothrombin fragment 1 in the pathway of regulatory exosite I formation during conversion of human prothrombin to thrombin. J Biol Chem 278:44489-95
Dai, Chunhua; Chung, Ik-Joo; Jiang, Shazi et al. (2003) Reduction of cell cycle progression in human erythroid progenitor cells treated with tumour necrosis factor alpha occurs with reduced CDK6 and is partially reversed by CDK6 transduction. Br J Haematol 121:919-27
Anderson, Patricia J; Nesset, Anna; Bock, Paul E (2003) Effects of activation peptide bond cleavage and fragment 2 interactions on the pathway of exosite I expression during activation of human prethrombin 1 to thrombin. J Biol Chem 278:44482-8
Qi, Ying; Zhao, Runxiang; Cao, Hongxi et al. (2002) Purification and characterization of protein tyrosine phosphatase PTP-MEG2. J Cell Biochem 86:79-89
Zhao, Runxiang; Guerrah, Abdelmadjid; Tang, Hua et al. (2002) Cell surface glycoprotein PZR is a major mediator of concanavalin A-induced cell signaling. J Biol Chem 277:7882-8
Zhao, R; Qi, Y; Chen, J et al. (2001) FYVE-DSP2, a FYVE domain-containing dual specificity protein phosphatase that dephosphorylates phosphotidylinositol 3-phosphate. Exp Cell Res 265:329-38
Chen, J; Qi, Y; Zhao, R et al. (2001) Assay of protein tyrosine phosphatases by using matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Anal Biochem 292:51-8
Anderson, P J; Bock, P E (2001) Biotin derivatives of D-Phe-Pro-Arg-CH2Cl for active-site-specific labeling of thrombin and other serine proteinases. Anal Biochem 296:254-61

Showing the most recent 10 out of 85 publications