Abstract

The research training program in hematology at Columbia University has been in existence for over 30 years and has trained numerous physicians and Ph.D.s to do basic research related to hematology. The current structure of the program divides the research preceptors into six broad areas. Research training is offered in: (1) Human globin gene regulation and hemoglobin switching (preceptors Drs. Bank and Constantini); (2) Gene transfer into hematopoietic progenitors (research preceptors Drs. Bank, Hesdorffer, Antman, Reiss, and Flamm); (3) Erythrocyte metabolism including red cell enzymes (research preceptor Dr. Piomelli), cobalamine and folate metabolism (Lindenbaum); (4) Gene-based diagnosis of hematologic diseases (research preceptors Drs. Piomelli and Dalla- Favera); (5) Molecular and immunologic aspects of hematologic malignancies (research preceptors Drs. Dalla-Favera and Chess); (6) Oncogenes in the control of cell proliferation (research preceptors Drs. Weinstein, Dalla-Favera, Goff, Stein, and Silverstein).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007373-24
Application #
2770308
Study Section
Special Emphasis Panel (SRC)
Program Officer
Bishop, Terry Rogers
Project Start
1980-08-15
Project End
2000-08-31
Budget Start
1998-09-15
Budget End
1999-08-31
Support Year
24
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Columbia University (N.Y.)
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032

  Publications

Landreth, Hannah; Malow, Beth A; Shoemaker, Ashley H (2015) Increased Prevalence of Sleep Apnea in Children with Pseudohypoparathyroidism Type 1a. Horm Res Paediatr 84:1-5
Mantha, Simon; Ward, Maureen; McCafferty, Jonathan et al. (2007) Activating Notch1 mutations are an early event in T-cell malignancy of Ikaros point mutant Plastic/+ mice. Leuk Res 31:321-7
Bank, Arthur (2006) Regulation of human fetal hemoglobin: new players, new complexities. Blood 107:435-43
Pulte, Dianne; Lopez, Rocio A; Baker, Shane T et al. (2006) Ikaros increases normal apoptosis in adult erythroid cells. Am J Hematol 81:12-8
Bank, Arthur; O'Neill, David; Lopez, Rocio et al. (2005) Role of intergenic human gamma-delta-globin sequences in human hemoglobin switching and reactivation of fetal hemoglobin in adult erythroid cells. Ann N Y Acad Sci 1054:48-54
Tsai, James C; McClure, Cori A; Ramos, Sarah E et al. (2003) Compliance barriers in glaucoma: a systematic classification. J Glaucoma 12:393-8
Ward, Maureen; Sattler, Rose; Grossman, I Robert et al. (2003) A stable murine-based RD114 retroviral packaging line efficiently transduces human hematopoietic cells. Mol Ther 8:804-12
Bradley, M Brigid; Sattler, Rose M; Raftopoulos, Harry et al. (2002) Correction of phenotype in a thalassemia mouse model using a nonmyeloablative marrow transplantation regimen. Biol Blood Marrow Transplant 8:453-61
Castle, M; O'Neill, D; Bank, A (1993) In vitro transcription from the human A gamma-globin gene promoter. Blood 82:1344-50
DelaFlor-Weiss, E; Richardson, C; Ward, M et al. (1992) Transfer and expression of the human multidrug resistance gene in mouse erythroleukemia cells. Blood 80:3106-11

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