The Pediatric GI program at Children's Hospital (CH) and Massachusetts General Hospital (MGH) is dedicated to the preparation of academic investigators to a career in GI biomedical research. This program continues to build on its outstanding past experience in establishing productive and committed investigators. Fundamental features of the post-doctoral training format, the major component of this program, include direct research participation in conjunction with a comprehensive program of didactic instruction and enrichment activities to provide a deep foundation in biomedical science and modern research techniques. In addition, a new pre-doctoral laboratory research program is proposed to attract graduate students from the Division of Medical Sciences at Harvard Medical School (HMS) to choose careers in GI research. (A) Research Areas and Disciplines. The majority of trainees will undertake training in laboratory research in which emphasis is placed on the application of tools of molecular biology to GI research. Training is offered in several disciplines: Molecular Biology, Developmental Biology, Genetics and Immunology. These disciplines are applied to four research themes central to the current study of digestive diseases. For the few trainees undertaking training in clinical investigation, a rigorous preparation in relevant quantitative sciences, including Biostatistics and Epidemiology, is provided: (B) Level of Training, Background and Numbers of Trainees. This renewal proposes both post-doctoral and pre-doctoral training. Post-doctoral training is offered in individuals holding M.D.-Ph.D. degrees. Six post- doctoral positions are requested: three post-doctoral fellows will begin training each year, and remain in research training for a minimum of two years supported by this award. In addition, two positions are requested to initiate a new pre-doctoral program for outstanding graduate students at Harvard Medical School completing an undergraduate degree or enrolled in medical school. C) Training Facilities. Research training will take place in the existing laboratories of the research mentors; a group of established investigators with extensive existing interactions at M.I.T, Harvard Medical School and HSPH. Laboratories are present at MGH-East and in the Enders Research Building at CH. Didactic educational program will include those offered through the Harvard Medical School, the Harvard School of Public Health, Harvard University and M.I.T.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007477-17
Application #
6124740
Study Section
Special Emphasis Panel (SRC)
Program Officer
Podskalny, Judith M,
Project Start
1983-12-01
Project End
2003-11-30
Budget Start
1999-12-01
Budget End
2000-11-30
Support Year
17
Fiscal Year
2000
Total Cost
$225,990
Indirect Cost
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Garcia-Castillo, Maria Daniela; Chinnapen, Daniel J-F; Te Welscher, Yvonne M et al. (2018) Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids. Elife 7:
Jimenez, Lissette; Stamm, Danielle A; Depaula, Brittany et al. (2018) Is Serum Methylmalonic Acid a Reliable Biomarker of Vitamin B12 Status in Children with Short Bowel Syndrome: A Case Series. J Pediatr 192:259-261
Duncan, Daniel R; Mitchell, Paul D; Larson, Kara et al. (2018) Presenting Signs and Symptoms do not Predict Aspiration Risk in Children. J Pediatr 201:141-146
Gosselin, Kerri B; Aboud, Said; McDonald, Christine M et al. (2017) Etiology of Diarrhea, Nutritional Outcomes, and Novel Intestinal Biomarkers in Tanzanian Infants. J Pediatr Gastroenterol Nutr 64:104-108
Hron, Bridget M; Ebbeling, Cara B; Feldman, Henry A et al. (2017) Hepatic, adipocyte, enteric and pancreatic hormones: response to dietary macronutrient composition and relationship with metabolism. Nutr Metab (Lond) 14:44
Gluchowski, Nina L; Chitraju, Chandramohan; Picoraro, Joseph A et al. (2017) Identification and characterization of a novel DGAT1 missense mutation associated with congenital diarrhea. J Lipid Res 58:1230-1237
Frank, S R; Köllmann, C P; van Lidth de Jeude, J F et al. (2017) The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion. Oncogene 36:1816-1828
Rosadini, Charles V; Kagan, Jonathan C (2017) Early innate immune responses to bacterial LPS. Curr Opin Immunol 44:14-19
Jimenez, Lissette; Duggan, Christopher P (2017) Biomarkers of Environmental Enteric Dysfunction: The Good, the Bad, and the Ugly. J Pediatr Gastroenterol Nutr 65:4-5
Mahoney, Lisa; Rosen, Rachel (2017) Feeding Problems and Their Underlying Mechanisms in the Esophageal Atresia-Tracheoesophageal Fistula Patient. Front Pediatr 5:127

Showing the most recent 10 out of 112 publications