The overarching goal of our Training Program is to prepare MD, MD/PhD pediatricians, and PhD scientists for careers in independent research on topics relevant to digestive diseases in infancy, childhood, and adult life. The rationale for our program is founded upon the idea that meaningful and strong intellectual, mentoring, and financial support for newly emerging scientists will enable the recruitment of talented young people to our field, and foster early success in their long-term career development as effective independent investigators pursuing meaningful science relevant to health and disease of the alimentary tract. We offer training in 4 broad areas relevant to our field of gastroenterology: * Epithelial Cell and Molecular Biology - including Stem Cell/Developmental Biology and Enteric Neurobiology * Innate and Adaptive Mucosal Immunology; * Microbial Pathogenesis, Gut Microbiome, and effects on Metabolism; and * Clinical Research. The training program provides an in-depth comprehensive and strongly mentored scientific experience for each trainee in a research group at the forefront of its field. Eight postdoctoral positions are requested. 37 NIH-funded highly-accomplished core reseach faculty support this effort, providing great depth and diversity of scientific training and over $49 million in combined current research support. Opportunities for cross-fertilization among faculty members and their trainees are abundant. The Program Director is Dr. Wayne I. Lencer MD, Longwood Professor of Pediatrics, Harvard Medical School, and a widely respected investigator and mentor. Program steering committee includes Drs. Scott Snapper MD PhD, Rachel Rosen MD MPH and Jon Kagan PhD. An External Advisory Board and an additional invited outside reviewer provide oversight to the program. Scholarship Oversight Committees (SOCs) are assembled for each trainee to provide oversight (and further mentoring) in personal scientific and career development. Didactic course work is encouraged for both basic and clinical research training and supplemented with relevant seminars and journal clubs, a course in the responsible conduct of research, and an annual research retreat. For clinical research trainees, the program supports matriculation trough a Master?s Degree in Medical Science or Public Heath (MMSc or MPH) from Harvard Medical School or Harvard School of Public Health. Since 1997, 88% of our past 89 Trainees remain in academics, 6% in industry, 2% in government (NIH/FDA), and 2% are in clinical practice. 21% of our past Trainees have achieved independent research awards (RO1 or equivalent) and 62% have achieved additional career development awards (NIH K-series and F-series and equivalent). Our program has populated the faculty of academic institutions across the nation and internationally.

Public Health Relevance

The goal of this application is to prepare MD, MD/PhD pediatricians, and PhD basic scientists for careers in independent research on topics relevant to digestive diseases in infancy, childhood, and adult life. Post-doctoral training in both basic and clinical research relevant to the GI tract is provided.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007477-37
Application #
9917761
Study Section
Kidney, Urologic and Hematologic Diseases D Subcommittee (DDK)
Program Officer
Densmore, Christine L
Project Start
1983-12-01
Project End
2024-04-30
Budget Start
2020-05-01
Budget End
2021-04-30
Support Year
37
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Boston Children's Hospital
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Garcia-Castillo, Maria Daniela; Chinnapen, Daniel J-F; Te Welscher, Yvonne M et al. (2018) Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids. Elife 7:
Jimenez, Lissette; Stamm, Danielle A; Depaula, Brittany et al. (2018) Is Serum Methylmalonic Acid a Reliable Biomarker of Vitamin B12 Status in Children with Short Bowel Syndrome: A Case Series. J Pediatr 192:259-261
Duncan, Daniel R; Mitchell, Paul D; Larson, Kara et al. (2018) Presenting Signs and Symptoms do not Predict Aspiration Risk in Children. J Pediatr 201:141-146
Hron, Bridget M; Ebbeling, Cara B; Feldman, Henry A et al. (2017) Hepatic, adipocyte, enteric and pancreatic hormones: response to dietary macronutrient composition and relationship with metabolism. Nutr Metab (Lond) 14:44
Gluchowski, Nina L; Chitraju, Chandramohan; Picoraro, Joseph A et al. (2017) Identification and characterization of a novel DGAT1 missense mutation associated with congenital diarrhea. J Lipid Res 58:1230-1237
Frank, S R; Köllmann, C P; van Lidth de Jeude, J F et al. (2017) The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion. Oncogene 36:1816-1828
Rosadini, Charles V; Kagan, Jonathan C (2017) Early innate immune responses to bacterial LPS. Curr Opin Immunol 44:14-19
Jimenez, Lissette; Duggan, Christopher P (2017) Biomarkers of Environmental Enteric Dysfunction: The Good, the Bad, and the Ugly. J Pediatr Gastroenterol Nutr 65:4-5
Mahoney, Lisa; Rosen, Rachel (2017) Feeding Problems and Their Underlying Mechanisms in the Esophageal Atresia-Tracheoesophageal Fistula Patient. Front Pediatr 5:127
Mahoney, Lisa B; Nurko, Samuel; Rosen, Rachel (2017) The Prevalence of Rome IV Nonerosive Esophageal Phenotypes in Children. J Pediatr 189:86-91

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