The purpose of this program is to train M.D.'s and Ph.D.'s for careers in neuroendocrinology research. The program focuses on the cellular physiology, biochemistry, and molecular biology of neuroendocrine systems, but extends to related areas of endocrine research as well, including growth factors, intracellular signaling mechanisms, and transcriptional regulation. The program is administered through the Vollum Institute, a major research unit of the Oregon Health Sciences University (OHSU). The Vollum Institute contains approximately 32,000 square feet of fully- equipped laboratory space with adjacent offices, conference rooms, and library. The focus of the institute since its inception has been on molecular endocrinology, reflecting the interests of the original director, Dr. Edward Herbert. The emphasis on endocrinology has extended to the rest of the OHSU campus, so that at the current time most of the major academic units are headed by leaders in the endocrinology field. Consequently, the training program is somewhat broader than that in the original program and includes several additional senior mentors. The training faculty now consists of twenty-one Vollum scientists and fourteen members of the Medicine, Neurology, Pediatrics, basic sciences, and Primate Center programs. The concentration of researchers in Oregon in the field of neuroendocrinology provides a unique environment for trainees.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007680-09
Application #
2905111
Study Section
Special Emphasis Panel (SRC)
Program Officer
Margolis, Ronald N
Project Start
1991-09-20
Project End
2001-06-30
Budget Start
1999-07-01
Budget End
2000-06-30
Support Year
9
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Neurosciences
Type
Schools of Medicine
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239
Horikoshi, Momoko; Day, Felix R; Akiyama, Masato et al. (2018) Elucidating the genetic architecture of reproductive ageing in the Japanese population. Nat Commun 9:1977
Toro, Carlos A; Wright, Hollis; Aylwin, Carlos F et al. (2018) Trithorax dependent changes in chromatin landscape at enhancer and promoter regions drive female puberty. Nat Commun 9:57
Mighell, Taylor L; Evans-Dutson, Sara; O'Roak, Brian J (2018) A Saturation Mutagenesis Approach to Understanding PTEN Lipid Phosphatase Activity and Genotype-Phenotype Relationships. Am J Hum Genet 102:943-955
Yoder, Nate; Gouaux, Eric (2018) Divalent cation and chloride ion sites of chicken acid sensing ion channel 1a elucidated by x-ray crystallography. PLoS One 13:e0202134
Toro, C A; Aylwin, C F; Lomniczi, A (2018) Hypothalamic epigenetics driving female puberty. J Neuroendocrinol 30:e12589
Yoder, Nate; Yoshioka, Craig; Gouaux, Eric (2018) Gating mechanisms of acid-sensing ion channels. Nature 555:397-401
Meinig, J Matthew; Ferrara, Skylar J; Banerji, Tania et al. (2017) Targeting Fatty-Acid Amide Hydrolase with Prodrugs for CNS-Selective Therapy. ACS Chem Neurosci 8:2468-2476
Ferrara, Skylar J; Meinig, J Matthew; Placzek, Andrew T et al. (2017) Ester-to-amide rearrangement of ethanolamine-derived prodrugs of sobetirome with increased blood-brain barrier penetration. Bioorg Med Chem 25:2743-2753
Placzek, Andrew T; Ferrara, Skylar J; Hartley, Meredith D et al. (2016) Sobetirome prodrug esters with enhanced blood-brain barrier permeability. Bioorg Med Chem 24:5842-5854
Toro, Cecilia; Trapani, Josef G; Pacentine, Itallia et al. (2015) Dopamine Modulates the Activity of Sensory Hair Cells. J Neurosci 35:16494-503

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