This training grant in developmental endocrinology and metabolism at Children's Hospital Boston intends to provide funding for postdoctoral fellows to engage in research training leading to independent careers in academic pediatric endocrinology. Trainees enter the program with either the MD, MD/PhD or occasionally the PhD degree, and are selected from highly qualified pediatric endocrinology fellows at Children's Hospital. The 28 trainers include 13 pediatric endocrine physician-scientists (including 5 MD/PhDs), 13 physician-scientists of other disciplines, and 2 PhD scientists. Children's Hospital is the major training site, along with laboratories at Massachusetts General Hospital, Beth Israel Deaconess Medical Center, Brigham and Women's Hospital, and Joslin Diabetes Center. The major areas of research emphasis in this training grant include clinical, translational and basic laboratory research in diabetes mellitus, obesity, neuroendocrinology, thyroid disease, bone health, stem cell biology, bioinformatics, ion transport, and human outcomes research. Training consists of didactic courses, including in quantitative methods and the ethical conduct of research, and an intensive period of individually mentored research. The intended average duration of training is two years. Of the 15 trainees during the past 10 years who have completed this training program, all but 1 are faculty in academic pediatric institutions (1 Professor, 2 Assistant Professors, 9 Instructors) and 2 are in industry. Of these, 3 have had independent NIH K awards, and 1 has an R01. Their record of publication is strong. This program takes advantage of the breadth of scientific expertise of the training faculty within the Division of Endocrinology, as well as in the larger Children's Hospital Boston community and surrounding Harvard environment.
This application aims to foster the training of a diverse and exceptionally well-trained group of postdoctoral fellows entering the field of pediatric endocrinology research through a training grant program at Children's Hospital Boston. To meet the growing biomedical research needs for pediatric endocrinology, each year we will provide training and support for 4 postdoctoral trainees for up to 2 years in this pediatric endocrinology training program. Based upon the extensive research programs of our faculty, and our record of successful career development of pediatric endocrinologists becoming independent researchers, we aim to support the training of a new group of pediatric endocrinology trainees who will become future leaders of academic pediatric research programs in the United States.
| Majzoub, Joseph A; Topor, Lisa Swartz (2018) A New Model for Adrenarche: Inhibition of 3?-Hydroxysteroid Dehydrogenase Type 2 by Intra-Adrenal Cortisol. Horm Res Paediatr 89:311-319 |
| James-Todd, Tamarra; March, Melissa I; Seiglie, Jacqueline et al. (2018) Racial differences in neonatal hypoglycemia among very early preterm births. J Perinatol 38:258-263 |
| Cherella, Christine E; Breault, David T; Thaker, Vidhu et al. (2018) Early Identification of Primary Hypothyroidism in Neonates Exposed to Intralymphatic Iodinated Contrast: A Case Series. J Clin Endocrinol Metab 103:3585-3588 |
| Cherella, Christine E; Feldman, Henry A; Hollowell, Monica et al. (2018) Natural History and Outcomes of Cytologically Benign Thyroid Nodules in Children. J Clin Endocrinol Metab 103:3557-3565 |
| Toce, Michael S; Stefater, Margaret A; Breault, David T et al. (2018) A case report of methadone-associated hypoglycemia in an 11-month-old male. Clin Toxicol (Phila) 56:74-76 |
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| Zhang, R; Asai, M; Mahoney, C E et al. (2017) Loss of hypothalamic corticotropin-releasing hormone markedly reduces anxiety behaviors in mice. Mol Psychiatry 22:733-744 |
| Wassner, Ari J; Jugo, Rebecca H; Dorfman, David M et al. (2017) Myocardial Induction of Type 3 Deiodinase in Dilated Cardiomyopathy. Thyroid 27:732-737 |
| Cherella, Christine E; Wassner, Ari J (2017) Congenital hypothyroidism: insights into pathogenesis and treatment. Int J Pediatr Endocrinol 2017:11 |
| Soto-Rivera, Carmen L; Asaro, Lisa A; Agus, Michael S D et al. (2017) Suspected Cerebral Edema in Diabetic Ketoacidosis: Is There Still a Role for Head CT in Treatment Decisions? Pediatr Crit Care Med 18:207-212 |
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