The current rapid pace of scientific discovery, particularly at the cellular, genomic, and molecular levels, offers unprecedented opportunities for direct application of basic scientific findings to the problem of clinical gastrointestinal disease. This progress will be optimized by providing rigorous training in research thought and technique to a select group of gastrointestinal surgeons who are already directed towards academic leadership.
The Specific Aim of this program, currently in its fourteenth year of funding, is to provide formal training in either clinical or laboratory research to this select group of individuals as an integral component of their postgraduate clinical training. One trainee per year is competitively selected from those entering the Advanced GI Surgery training program at Johns Hopkins. During the first three years of postgraduate clinical training, this trainee is guided to choose a senior investigator/mentor from our list of participating faculty, all of whom have demonstrated an outstanding record of independent basic scientific achievement, as well as an established record of successful trainee mentorship. The formal scientific training period begins after the third clinical year, and lasts for two-three consecutive years. This training period is uninterrupted by clinical duties, and includes formal training in research ethics as well as other elective course work tailored to individual interests and capabilities. Many of our trainees complete our program with additional Masters or Doctoral degrees. All trainees are assigned an Individual Progress Committee charged with critiquing the trainee's research, monitoring long-term progress towards an independent investigative career, and aiding in the selection of appropriate course work. Our trainees are immersed in an outstanding educational environment, which includes the Johns Hopkins Bloomberg School of Public Health, the McKusick-Nathans Institute of Genetic Medicine, the NIDDK-funded Johns Hopkins Digestive Diseases Research Core Center, and the NCI- funded Sidney Kimmel Comprehensive Cancer Center. The specific recruitment of underrepresented minorities to this program is enhanced by the activities of the School of Medicine's Office for Diversity, as well networking and advertising through the Society of Black Academic Surgeons. To date, eight program trainees have completed their combined clinical and research training. All eight have achieved full-time faculty positions in prominent institutions, including Johns Hopkins, UPenn, University of Michigan, UCSD, UCSF and Thomas Jefferson. Four of the eight have already achieved extramural research funding. In this manner, the program is designed to generate a highly selected group of GI surgeon-scientists who will provide academic leadership for the 21st century.!

Public Health Relevance

This application seeks ongoing funding for our T32 training program, currently in its fourteenth year of continuous funding. The program provides sophisticated clinical and research training to highly selected Johns Hopkins Surgery Residents pursing training in Advanced GI Surgery.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
2T32DK007713-16
Application #
8078724
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Densmore, Christine L
Project Start
1996-07-01
Project End
2016-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
16
Fiscal Year
2011
Total Cost
$174,825
Indirect Cost
Name
Johns Hopkins University
Department
Surgery
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Renz, Harald; Adkins, Becky D; Bartfeld, Sina et al. (2018) The neonatal window of opportunity-early priming for life. J Allergy Clin Immunol 141:1212-1214
Lu, P; Sodhi, C P; Yamaguchi, Y et al. (2018) Intestinal epithelial Toll-like receptor 4 prevents metabolic syndrome by regulating interactions between microbes and intestinal epithelial cells in mice. Mucosal Immunol 11:727-740
Martin, Laura Y; Ladd, Mitchell R; Werts, Adam et al. (2018) Tissue engineering for the treatment of short bowel syndrome in children. Pediatr Res 83:249-257
Hackam, David J; Sodhi, Chhinder P; Good, Misty (2018) New insights into necrotizing enterocolitis: From laboratory observation to personalized prevention and treatment. J Pediatr Surg :
Ladd, Mitchell R; Martin, Laura Y; Werts, Adam et al. (2018) The Development of Newborn Porcine Models for Evaluation of Tissue-Engineered Small Intestine. Tissue Eng Part C Methods 24:331-345
Niño, Diego F; Sodhi, Chhinder P; Egan, Charlotte E et al. (2017) Retinoic Acid Improves Incidence and Severity of Necrotizing Enterocolitis by Lymphocyte Balance Restitution and Repopulation of LGR5+ Intestinal Stem Cells. Shock 47:22-32
Fabrizio, Anne C; Grant, Michael C; Siddiqui, Zishan et al. (2017) Is enhanced recovery enough for reducing 30-d readmissions after surgery? J Surg Res 217:45-53
Poruk, Katherine E; Valero 3rd, Vicente; Saunders, Tyler et al. (2016) Circulating Tumor Cell Phenotype Predicts Recurrence and Survival in Pancreatic Adenocarcinoma. Ann Surg 264:1073-1081
Ladd, Mitchell R; Niño, Diego F; March, John C et al. (2016) Generation of an artificial intestine for the management of short bowel syndrome. Curr Opin Organ Transplant 21:178-85
Valero 3rd, Vicente; Saunders, Tyler J; He, Jin et al. (2016) Reliable Detection of Somatic Mutations in Fine Needle Aspirates of Pancreatic Cancer With Next-generation Sequencing: Implications for Surgical Management. Ann Surg 263:153-61

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