This competitive renewal application requests funding for the continuation of the existing Training Program in Signal Transduction and Cellular Endocrinology at the University of Illinois at Chicago. This predoctoral and postdoctoral training program provides interdisciplinary training in the related fields of signal transduction, gene transcription/translation, and cellular endocrinology, with emphasis on both cellular and molecular mechanisms that transduce signals and regulate cell, tissue and organismal responses to their external environment. The continuing goal of the training program is to develop independent basic science and clinical investigators, and to train doctoral candidates in broad aspects of signal transduction, cellular endocrinology, and gene transcription/translation. An underlying theme in this training program has been the coordination and promotion of interactions between pre-and post-doctoral researchers who are using different experimental systems and approaches toward understanding signal transduction mechanisms at various levels of organization including molecular, cellular and integrative biology. The training program crosses both disciplinary and departmental lines, drawing upon the expertise of thirty-three faculty from six basic science departments (anatomy and cell biology, biochemistry and molecular biology, molecular genetics, microbiology and immunology, pharmacology, physiology and biophysics) and three clinical sections (hematology-oncology, endocrinology and metabolism, rheumatology) in the Department of Medicine, and offering opportunities in a wide range of problems in signal transduction and allied areas using a broad spectrum of molecular, biochemical, physiologic, genetic, and structural biology approaches. The areas of signaling, cell cycle regulation, gene transcription, cancer biology, developmental biology, and endocrine and neurohumoral signaling represent major strengths of researchers at UIC and preceptors have been drawn from all these groups. Predoctoral training includes theory, techniques and research perspectives through didactic courses, research presentations, seminars, informal interactions, research rotations, and a yearly retreat. Courses in signal transduction, endocrinology, and a core curriculum in molecular and cellular biology, biochemistry, genetics, structural biology, physiology, and pharmacology, scientific communication, and responsible conduct of research provide the foundation for an intensive research environment. Faculty trainers' research interests range from neurohumoral signaling, membrane receptors and transduction mechanisms, to second messengers, cell cycle control, transcriptional/translational regulation, and structural biology. Postdoctoral fellows are trained in two or three year programs tailored to their research interests, background and specific course needs. All trainees are participants in Signal Transduction and other seminars, and an annual Chicago metropolitan area Signal Transduction Symposium which the program supports. The training program emphasizes the interdisciplinary nature of contemporary research in signal transduction in an environment that fosters independent and creative thinking. We anticipate that the program will ultimately contribute to the generation of outstanding independent investigators who will make significant contributions in the broad area of signal transduction, and who will ultimately serve to enrich scientific progress and community.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007739-10
Application #
7106490
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Hyde, James F
Project Start
1997-07-01
Project End
2007-09-29
Budget Start
2006-07-01
Budget End
2007-09-29
Support Year
10
Fiscal Year
2006
Total Cost
$122,871
Indirect Cost
Name
University of Illinois at Chicago
Department
Biochemistry
Type
Schools of Medicine
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612
Madueke, Ikenna C; Hu, Wen-Yang; Huang, Liwei et al. (2018) WNT2 is necessary for normal prostate gland cyto-differentiation and modulates prostate growth in an FGF10 dependent manner. Am J Clin Exp Urol 6:154-163
Choi, J S; Kim, K-H; Lau, L F (2015) The matricellular protein CCN1 promotes mucosal healing in murine colitis through IL-6. Mucosal Immunol 8:1285-96
Le, Jamie A; Wilson, Heather M; Shehu, Aurora et al. (2012) Generation of mice expressing only the long form of the prolactin receptor reveals that both isoforms of the receptor are required for normal ovarian function. Biol Reprod 86:86
Nogueira, Veronique; Sundararajan, Deepa; Kwan, Jennifer M et al. (2012) Akt-dependent Skp2 mRNA translation is required for exiting contact inhibition, oncogenesis, and adipogenesis. EMBO J 31:1134-46
Gierut, Jessica J; Mathur, Priya S; Bie, Wenjun et al. (2012) Targeting protein tyrosine kinase 6 enhances apoptosis of colon cancer cells following DNA damage. Mol Cancer Ther 11:2311-20
Zimnicka, Adriana M; Ivy, Kristin; Kaplan, Jack H (2011) Acquisition of dietary copper: a role for anion transporters in intestinal apical copper uptake. Am J Physiol Cell Physiol 300:C588-99
Gierut, Jessica; Zheng, Yu; Bie, Wenjun et al. (2011) Disruption of the mouse protein tyrosine kinase 6 gene prevents STAT3 activation and confers resistance to azoxymethane. Gastroenterology 141:1371-80, 1380.e1-2
Ellis, Anne K; Ackerman, Steven J; Crawford, Lynn et al. (2010) Cord blood molecular biomarkers of eosinophilopoiesis: kinetic analysis of GATA-1, MBP1 and IL-5R alpha mRNA expression. Pediatr Allergy Immunol 21:640-8
Lye, Ming F; Fanning, Alan S; Su, Ying et al. (2010) Insights into regulated ligand binding sites from the structure of ZO-1 Src homology 3-guanylate kinase module. J Biol Chem 285:13907-17
Palka-Hamblin, Helena L; Gierut, Jessica J; Bie, Wenjun et al. (2010) Identification of beta-catenin as a target of the intracellular tyrosine kinase PTK6. J Cell Sci 123:236-45

Showing the most recent 10 out of 38 publications