This proposal seeks continuation of support for the Training Program in Endocrinology, Diabetes, and Metabolism (EDM) at Cedars-Sinai Medical Center. Consistent with the 17-year history of this program, our goal is to train postgraduate scientists and physician-scientists in the study of thyroid disorders, reproductive endocrinology, diabetes/metabolism, endocrine oncology, endocrine hypertension, and neuroendocrinology. Under the guidance of Shlomo Melmed, MD, and Richard Bergman, PhD, 20 Faculty Preceptors, 50% of whom are female and 35% of whom are junior faculty, will guide our trainees for investigative careers in endocrinology through curriculum-based instruction, intensive research training, multidisciplinary interactions, and interactive translational research. Our Faculty Preceptors are a strength of this program, with $21 million dollars in funding per year, and their productivity led to 1336 publications over the last ten years by our trainees. We will continue this success with program improvements, including expanded areas of research, improved program assessment and tracking, increased trainee recruitment from underrepresented minorities, and addition of senior faculty to mentor junior preceptors and enrich their mentorship experience. We are requesting funding support for three postdoctoral positions in our quest to accelerate training for translational discovery in EDM research.
Endocrinology-related diseases are a major area of health concern for today's society. For the past 17 years, the Training Program in Endocrinology, Diabetes, and Metabolism at Cedars-Sinai Medical Center has successfully addressed the specialized training of scientists in several areas of endocrinology research, including diabetes and obesity, endocrine oncology, and neuroendocrinology. Continuing this program for another five years will enable us to continue training postdoctoral scientists and physician-scientists in this important area.
| Araki, Takako; Liu, Ning-Ai (2018) Cell Cycle Regulators and Lineage-Specific Therapeutic Targets for Cushing Disease. Front Endocrinol (Lausanne) 9:444 |
| Yamamoto, Masaaki; Ben-Shlomo, Anat; Kameda, Hiraku et al. (2018) Somatostatin receptor subtype 5 modifies hypothalamic-pituitary-adrenal axis stress function. JCI Insight 3: |
| Gonzalez, Tania L; Sun, Tianyanxin; Koeppel, Alexander F et al. (2018) Sex differences in the late first trimester human placenta transcriptome. Biol Sex Differ 9:4 |
| Ehrhardt, Nicole; Doche, Michael E; Chen, Shuang et al. (2017) Hepatic Tm6sf2 overexpression affects cellular ApoB-trafficking, plasma lipid levels, hepatic steatosis and atherosclerosis. Hum Mol Genet 26:2719-2731 |
| Recouvreux, M Victoria; Wu, J Boyang; Gao, Allen C et al. (2017) Androgen Receptor Regulation of Local Growth Hormone in Prostate Cancer Cells. Endocrinology 158:2255-2268 |
| Smith, Bethany N; Bhowmick, Neil A (2016) Role of EMT in Metastasis and Therapy Resistance. J Clin Med 5: |
| Araki, Takako; Liu, Ning-Ai; Tone, Yukiko et al. (2016) E2F1-mediated human POMC expression in ectopic Cushing's syndrome. Endocr Relat Cancer 23:857-870 |
| Chesnokova, Vera; Zonis, Svetlana; Zhou, Cuiqi et al. (2016) Growth hormone is permissive for neoplastic colon growth. Proc Natl Acad Sci U S A 113:E3250-9 |
| Melmed, Shlomo (2016) Pituitary Medicine From Discovery to Patient-Focused Outcomes. J Clin Endocrinol Metab 101:769-77 |
| Shah, Kandarp H; Shi, Peng; Giani, Jorge F et al. (2015) Myeloid Suppressor Cells Accumulate and Regulate Blood Pressure in Hypertension. Circ Res 117:858-69 |
Showing the most recent 10 out of 31 publications
