The long-term goal of this Research Training Program is to develop a new generation of pediatric endocrinologists who will be equipped to carry out innovative and scientifically rigorous patient-oriented and laboratory-based research related to diabetes mellitus in children for this new 21st Century. One of the needs for this Program is the critical shortage of academic pediatric endocrinologists in diabetes research which has been emphasized by the organizations such as the American Diabetes Association, the Juvenile Diabetes Research Foundation, and the Pediatric Academic Societies. In addition, the Program recognizes the important new opportunities for advancing diabetes research in children provided by such recent scientific advances as the Human Genome Project and the successes in islet transplantation and production of biomechanical and bio-engineered islets. The Program will support Trainees during up to 2 years of research training at the fellowship level. The Training faculty includes 19 scientific mentors from the Children's Hospital and the U Penn School of Medicine who have outstanding credentials and active research programs and training records. These mentors will supervise Trainees' in basic laboratory research and/or patient-oriented research projects related to diabetes in children. Research opportunities will include three major areas of basic research 1) Signal Transduction: Mechanisms of Hormone Action; 2) Regulation of Pancreatic beta-cell Function and Development; and 3) Genetic Approaches to Diabetes and Endocrine Diseases. Patient-oriented research opportunities will include the areas of 1) Islet Immunology, Transplantation, and Regulation; 2) Obesity and Insulin Resistance, 3) Diabetes Complications; and 4) Diabetes Epidemiology and Biostatistics. The Program includes training in all aspects of research, including biostatistics, bioethics, molecular biology, etc. The Program is strongly supported by access to a superb range of institutional resources, including the CHOP GCRC and the UPenn DERC. Request is made for 3 Trainee slots in this Program each year.
| Gannon, Anthony W; Langer, Jill E; Bellah, Richard et al. (2018) Diagnostic Accuracy of Ultrasound With Color Flow Doppler in Children With Thyroid Nodules. J Clin Endocrinol Metab 103:1958-1965 |
| McCormack, Shana E; Cousminer, Diana L; Chesi, Alessandra et al. (2017) Association Between Linear Growth and Bone Accrual in a Diverse Cohort of Children and Adolescents. JAMA Pediatr 171:e171769 |
| Leichner, Theresa M; Satake, Atsushi; Harrison, Victor Sanoe et al. (2017) Skin-derived TSLP systemically expands regulatory T cells. J Autoimmun 79:39-52 |
| Pinney, Sara E; Mesaros, Clementina A; Snyder, Nathaniel W et al. (2017) Second trimester amniotic fluid bisphenol A concentration is associated with decreased birth weight in term infants. Reprod Toxicol 67:1-9 |
| Hanley, Patrick; Sutter, Jennifer A; Goodman, Noah G et al. (2017) Circulating B cells in type 1 diabetics exhibit fewer maturation-associated phenotypes. Clin Immunol 183:336-343 |
| Harrison, V Sanoe; Rustico, Stacy; Palladino, Andrew A et al. (2017) Glargine co-administration with intravenous insulin in pediatric diabetic ketoacidosis is safe and facilitates transition to a subcutaneous regimen. Pediatr Diabetes 18:742-748 |
| Harrison, Victor S; Oatman, Oliver; Kerrigan, John F (2017) Hypothalamic hamartoma with epilepsy: Review of endocrine comorbidity. Epilepsia 58 Suppl 2:50-59 |
| McCormack, Shana E; Chesi, Alessandra; Mitchell, Jonathan A et al. (2017) Relative Skeletal Maturation and Population Ancestry in Nonobese Children and Adolescents. J Bone Miner Res 32:115-124 |
| Kelley, Jennifer C; Crabtree, Nicola; Zemel, Babette S (2017) Bone Density in the Obese Child: Clinical Considerations and Diagnostic Challenges. Calcif Tissue Int 100:514-527 |
| Roizen, Jeffrey D; Danzig, Jennifer; Groleau, Veronique et al. (2016) Resting Energy Expenditure Is Decreased in Pseudohypoparathyroidism Type 1A. J Clin Endocrinol Metab 101:880-8 |
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