The goal of this training program is to provide a solid foundation upon which to build a productive and independent career in Biomechanics in Regenerative Medicine (BiRM). This goal is accomplished via a highly coordinated and mentored interdisciplinary training program with a combination of required and elective courses, research activities, and specialized training opportunities. The proposed Training Program incorporates faculty from the Departments of Bioengineering, Mechanical Engineering, Orthopedic Surgery, Vascular Surgery, Urology, and the McGowan Institute for Regenerative Medicine of the University of Pittsburgh, as well as faculty from the Mechanical and Biomedical Engineering Departments from Carnegie Mellon University. This combination of training faculty research interests and coursework will provide a rich educational experience and more numerous training opportunities for the students than could be obtained within the individual university departments. Moreover, the breadth of research areas that span various physiological systems (cardiovascular, musculo-skeletal, urological) allows for a unique opportunity to train students to become highly skilled problem'solvers while avoiding over specialization. Since the BiRM training program is not central to any one department, its structure permits the student a much wider choice of options with which to pursue a PhD in tissue bioengineering and regeneration. In the current departmental focus of graduate education, a PhD student in one department that wishes to perform thesis research in a laboratory in another department finds many departmental based administrative roadblocks in his/her path. The BiRM program eliminates these roadblocks and permits ever increasing educational options for the students and research collaborations. Coursework includes intensive life science, and biomechanics is utilized to provide the students with a thorough grounding in both areas. Skills acquired in these courses are combined in later courses and the trainees'research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Institutional National Research Service Award (T32)
Project #
5T32EB003392-05
Application #
7663896
Study Section
Special Emphasis Panel (ZEB1-OSR-B (S))
Program Officer
Baird, Richard A
Project Start
2005-08-01
Project End
2011-07-31
Budget Start
2009-08-01
Budget End
2011-07-31
Support Year
5
Fiscal Year
2009
Total Cost
$271,444
Indirect Cost
Name
University of Pittsburgh
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Shawky, Joseph H; Balakrishnan, Uma L; Stuckenholz, Carsten et al. (2018) Multiscale analysis of architecture, cell size and the cell cortex reveals cortical F-actin density and composition are major contributors to mechanical properties during convergent extension. Development 145:
López-Escobar, Beatriz; Caro-Vega, José Manuel; Vijayraghavan, Deepthi S et al. (2018) The non-canonical Wnt-PCP pathway shapes the mouse caudal neural plate. Development 145:
Armiger, Travis J; Lampi, Marsha C; Reinhart-King, Cynthia A et al. (2018) Determining mechanical features of modulated epithelial monolayers using subnuclear particle tracking. J Cell Sci 131:
Szymanski, John M; Sevcik, Emily N; Zhang, Kairui et al. (2017) Stretch-dependent changes in molecular conformation in fibronectin nanofibers. Biomater Sci 5:1629-1639
Szymanski, John M; Zhang, Kairui; Feinberg, Adam W (2017) Measuring the Poisson's Ratio of Fibronectin Using Engineered Nanofibers. Sci Rep 7:13413
Tamimi, Ehab A; Pyne, Jeffrey D; Muli, Dominic K et al. (2017) Racioethnic Differences in Human Posterior Scleral and Optic Nerve Stump Deformation. Invest Ophthalmol Vis Sci 58:4235-4246
Long, Daniel W; Johnson, Noah R; Jeffries, Eric M et al. (2017) Controlled delivery of platelet-derived proteins enhances porcine wound healing. J Control Release 253:73-81
Robbins, Constance M; Raghavan, Guruprasad; Antaki, James F et al. (2017) Feasibility of spatial frequency-domain imaging for monitoring palpable breast lesions. J Biomed Opt 22:1-9
Chanet, Soline; Miller, Callie J; Vaishnav, Eeshit Dhaval et al. (2017) Actomyosin meshwork mechanosensing enables tissue shape to orient cell force. Nat Commun 8:15014
Soohoo, Elaine; Waldman, Lewis K; Trumble, Dennis R (2017) Computational Parametric Studies Investigating the Global Hemodynamic Effects of Applied Apical Torsion for Cardiac Assist. Ann Biomed Eng 45:1434-1448

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