The field of microfluidics is uniquely poised to make a broad impact in biomedical science through the miniaturization and massive parallelization of biological experimentation. For example, future advances in microfluidics could revolutionize disease diagnosis, drug discovery, and pathogen detection. For these impacts to be realized we need people conversant in engineering, chemistry, biological sciences, and the medical sciences. Currently, however, such cross-trained people are in short supply. To address this shortage, we propose a five-year program to train the next generation of biomedical microfluidics experts. This program combines the expertise of faculty from engineering, chemistry, and the medical school plus the world-class Solid State Electronics Laboratory (SSEL) and Micromechanical Integrated DMA Analysis Technology (MIDAT) facilities for state-of-the-art micro- and nanofabrication. The premise of the program is that students should have significant training in both the methods of microfluidics and in the biomedical applications of this technology. Such training enhance the communication between disciplines, identification of solvable and clinically relevant problems, and selection of appropriate tools to solve these problems. The training of the students in this program will involve a combination of lecture and lab course work, a seminar and workshop program, a cross-disciplinary laboratory rotation and co-mentor, and an annual symposium beyond the requirements in the trainee's home department. The core course for the program, """"""""Transport in Microfluidic Systems,"""""""" has already been developed two years ago. Students from both engineering and basic sciences have completed the course. The seminar and workshop program, developed and run by the graduate students, was established last year and has been very successful. The series has workshop and tutorial sessions teaching principles in microfluidics in addition to both internal and external speakers. We hope to put in place the additional programs with the funding of this proposal. We feel that this combination of practical training, cross-disciplinary exposure, and intensive microfluidic study will produce students well positioned to answer the growing need for highly educated and trained microfluidic experts.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Institutional National Research Service Award (T32)
Project #
5T32EB005582-03
Application #
7258812
Study Section
Special Emphasis Panel (ZEB1-OSR-B (O1))
Program Officer
Baird, Richard A
Project Start
2005-09-30
Project End
2010-08-31
Budget Start
2007-09-01
Budget End
2008-08-31
Support Year
3
Fiscal Year
2007
Total Cost
$244,614
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Jordahl, Jacob H; Solorio, Luis; Sun, Hongli et al. (2018) 3D Jet Writing: Functional Microtissues Based on Tessellated Scaffold Architectures. Adv Mater 30:e1707196
Lee, Jin Woo; Daly, Shanna R; Huang-Saad, Aileen Y et al. (2018) Using design strategies from microfluidic device patents to support idea generation. Microfluid Nanofluidics 22:70
Syverud, Brian C; Lin, Eric; Nagrath, Sunitha et al. (2018) Label-Free, High-Throughput Purification of Satellite Cells Using Microfluidic Inertial Separation. Tissue Eng Part C Methods 24:32-41
Ho, Kenneth K Y; Lee, Jin Woo; Durand, Grégory et al. (2017) Protein aggregation with poly(vinyl) alcohol surfactant reduces double emulsion-encapsulated mammalian cell-free expression. PLoS One 12:e0174689
Decker, Joseph T; Hobson, Eric C; Zhang, Yining et al. (2017) Systems analysis of dynamic transcription factor activity identifies targets for treatment in Olaparib resistant cancer cells. Biotechnol Bioeng 114:2085-2095
Ramamurthy, Poornapriya; White, Joshua B; Yull Park, Joong et al. (2017) Concomitant differentiation of a population of mouse embryonic stem cells into neuron-like cells and schwann cell-like cells in a slow-flow microfluidic device. Dev Dyn 246:7-27
Spinosa, Phillip C; Luker, Kathryn E; Luker, Gary D et al. (2017) The CXCL12/CXCR7 signaling axis, isoforms, circadian rhythms, and tumor cellular composition dictate gradients in tissue. PLoS One 12:e0187357
Labuz, Joseph M; Moraes, Christopher; Mertz, David R et al. (2017) Building an experimental model of the human body with non-physiological parameters. Technology (Singap World Sci) 5:42-59
Ferguson, Stephen A; Meyerhoff, Mark E (2017) Manual and Flow-Injection Detection/Quantification of Polyquaterniums via Fully Reversible Polyion-Sensitive Polymeric Membrane-Based Ion-Selective Electrodes. ACS Sens 2:1505-1511
Syverud, Brian C; VanDusen, Keith W; Larkin, Lisa M (2016) Growth Factors for Skeletal Muscle Tissue Engineering. Cells Tissues Organs 202:169-179

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