? ? The purpose of this Training Program is to develop well-trained environmental pathologists, who have a broad and comprehensive understanding of major human diseases and who are expert in the techniques and strategies that can disclose mechanisms by which environmental pollutants perturb cellular processes to cause disease. The Program focuses on cancer, its etiology and pathogenesis, cytotoxicity and neurodegenerative diseases because this group of diseases and the processes by which they develop continue to be major problem facing environmental risk assessors and are strengths of the faculty of this Program. The Program draws its faculty from the Department of Pathology at the University of North Carolina at Chapel Hill (UNC), from other departments at UNC and from various federal, industrial and independent research laboratories in Research Triangle Park. The Program offers the Ph.D. degree in molecular pathology and postdoctoral training in research. It also participates in a research program for minority undergraduates. ? ? Predoctoral candidates must have completed a B.S./B.A. or M.S. degree in a relevant scientific discipline of biological science or chemistry, or hold an M.D. or DVM degree. Applicants are evaluated based on their undergraduate academic record, GRE test scores, letters of recommendation, and interview. A faculty committee reviews candidates and makes nominations to the Graduate School for formal offers of admission and for traineeships. Applicants for postdoctoral training are evaluated based on their previous academic/research records and their perceived scientific potential for future development. Postdoctoral candidates are selected by a Program Committee. Minority candidates are actively sought for predoctoral and postdoctoral training, and for the undergraduate research program. The Program has an established record in the training of minority scientists. ? ? The training facilities of the faculty consist of more than 40,000 square feet of active research laboratories performing state-of-science research on various aspects of environmental carcinogenesis/ mutagenesis and neuropathology. The Program is centered in a comprehensive human pathology department with active training programs in human and experimental pathology, highly regarded research programs on molecular and cellular pathology, and modern diagnostic services. Faculty members also participate on various risk assessment panels. Excellent facilities, outstanding faculty and research projects characterize this Training Program. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Institutional National Research Service Award (T32)
Project #
5T32ES007017-32
Application #
7126487
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Humble, Michael C
Project Start
1975-07-01
Project End
2010-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
32
Fiscal Year
2006
Total Cost
$426,384
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Pathology
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Cordeiro-Stone, Marila; McNulty, John J; Sproul, Christopher D et al. (2016) Effective intra-S checkpoint responses to UVC in primary human melanocytes and melanoma cell lines. Pigment Cell Melanoma Res 29:68-80
Pfefferle, Adam D; Spike, Benjamin T; Wahl, Geoff M et al. (2015) Luminal progenitor and fetal mammary stem cell expression features predict breast tumor response to neoadjuvant chemotherapy. Breast Cancer Res Treat 149:425-37
Karaca, Mehmet; Liu, Yuanbo; Zhang, Zhentao et al. (2015) Mutation of androgen receptor N-terminal phosphorylation site Tyr-267 leads to inhibition of nuclear translocation and DNA binding. PLoS One 10:e0126270
Song, Shujie; Walter, Vonn; Karaca, Mehmet et al. (2014) Gene silencing associated with SWI/SNF complex loss during NSCLC development. Mol Cancer Res 12:560-70
Pfefferle, Adam D; Herschkowitz, Jason I; Usary, Jerry et al. (2013) Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts. Genome Biol 14:R125
Kesseler, Kevin J; Blinov, Michael L; Elston, Timothy C et al. (2013) A predictive mathematical model of the DNA damage G2 checkpoint. J Theor Biol 320:159-69
Wang, Jian-Guo; Geddings, Julia E; Aleman, Maria M et al. (2012) Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer. Blood 119:5543-52
Sanders, Alison P; Flood, Kaye; Chiang, Shu et al. (2012) Towards prenatal biomonitoring in North Carolina: assessing arsenic, cadmium, mercury, and lead levels in pregnant women. PLoS One 7:e31354
Roth, Aleeza J; Brown, Michael C; Smith, Rex Neal et al. (2012) Anti-LAMP-2 antibodies are not prevalent in patients with antineutrophil cytoplasmic autoantibody glomerulonephritis. J Am Soc Nephrol 23:545-55
Wolberg, Alisa S; Aleman, Maria M; Leiderman, Karin et al. (2012) Procoagulant activity in hemostasis and thrombosis: Virchow's triad revisited. Anesth Analg 114:275-85

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