The Duke University Integrated Toxicology Training Program (ITP) has been an important component of science education and research at Duke University since 1978. Its mission is to provide outstanding pre-doctoral and postdoctoral training in toxicology and thus to contribute both to the advancement of the field as well as to the careers of the individual trainees. The ITP is an interdepartmental and multi-disciplinary program in which Ph.D. degrees are awarded jointly by the Department and the Program. Post-doctoral trainees perform toxicological research under the mentorship of ITP faculty, and are tightly integrated into the program through seminars, symposia, poster programs, governance committees, and participation as students and lecturers in ITP core courses. There are four, well-established research strengths in toxicology at Duke University, and trainees with interests in and aptitudes for these areas are targeted for recruitment: Mutagenesis and Carcinogenesis, Oxidative Stress and Pulmonary Toxicology, Endocrine Disruptors and Developmental Toxicology, and Neurotoxicology. At the core of the Program is the excellent academic and research environment provided by participating units from the Duke University Medical Center, the Nicholas School of the Environment, and Trinity College of Arts and Sciences. This year (2000), two premier scientists have been recruited to the Duke ITP, David Hinton (first Nicholas Chair of Environmental Toxicology) and David Schwartz (Director of the Division of Pulmonary and Critical Care Medicine). Currently there are 26 core Duke faculty in the ITP that can serve as primary advisors for Ph.D. students or as preceptors for postdoctoral fellows. The program is enriched by the participation of additional adjunct faculty associated with the Research Triangle Park-based institutions such as the NIEHS, the U.S. EPA, and the Chemical Industries Institute of Toxicology. These faculty provide seminars, guest lectures in courses, serve on student committees, and/or provide technical expertise and research facilities. Through the ITP, students and research associates receive classroom and laboratory training that prepares them for competitive research at the highest level. This success depends in good part on the investigators ability to attract excellent students into the program, and our recruiting and admissions efforts have consistently provided us with outstanding young people eager to embark upon a career in toxicology. This competitive renewal includes a number of changes in the faculty and organizational structure of the ITP that will enhance the ability of the ITP to attract the brightest toxicology students in the U.S. and provide them with the educational opportunities they deserve.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Institutional National Research Service Award (T32)
Project #
2T32ES007031-21A1
Application #
6314933
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol K
Project Start
1978-07-01
Project End
2006-06-30
Budget Start
2001-07-01
Budget End
2002-06-30
Support Year
21
Fiscal Year
2001
Total Cost
$379,391
Indirect Cost
Name
Duke University
Department
Type
Schools of Earth Sciences/Natur
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Mu, Jingli; Chernick, Melissa; Dong, Wu et al. (2017) Early life co-exposures to a real-world PAH mixture and hypoxia result in later life and next generation consequences in medaka (Oryzias latipes). Aquat Toxicol 190:162-173
Brown, D R; Bailey, J M; Oliveri, A N et al. (2016) Developmental exposure to a complex PAH mixture causes persistent behavioral effects in naive Fundulus heteroclitus (killifish) but not in a population of PAH-adapted killifish. Neurotoxicol Teratol 53:55-63
Arnold, M C; Forte, J E; Osterberg, J S et al. (2016) Antioxidant Rescue of Selenomethionine-Induced Teratogenesis in Zebrafish Embryos. Arch Environ Contam Toxicol 70:311-20
Jayasundara, Nishad; Van Tiem Garner, Lindsey; Meyer, Joel N et al. (2015) AHR2-Mediated transcriptomic responses underlying the synergistic cardiac developmental toxicity of PAHs. Toxicol Sci 143:469-81
Brown, Daniel R; Clark, Bryan W; Garner, Lindsey V T et al. (2015) Zebrafish cardiotoxicity: the effects of CYP1A inhibition and AHR2 knockdown following exposure to weak aryl hydrocarbon receptor agonists. Environ Sci Pollut Res Int 22:8329-38
Luz, Anthony L; Smith, Latasha L; Rooney, John P et al. (2015) Seahorse Xfe 24 Extracellular Flux Analyzer-Based Analysis of Cellular Respiration in Caenorhabditis elegans. Curr Protoc Toxicol 66:25.7.1-15
Massarsky, Andrey; Jayasundara, Nishad; Bailey, Jordan M et al. (2015) Teratogenic, bioenergetic, and behavioral effects of exposure to total particulate matter on early development of zebrafish (Danio rerio) are not mimicked by nicotine. Neurotoxicol Teratol 51:77-88
Di Giulio, Richard T; Clark, Bryan W (2015) The Elizabeth River Story: A Case Study in Evolutionary Toxicology. J Toxicol Environ Health B Crit Rev 18:259-98
Clark, Bryan W; Bone, A J; Di Giulio, R T (2014) Resistance to teratogenesis by F1 and F2 embryos of PAH-adapted Fundulus heteroclitus is strongly inherited despite reduced recalcitrance of the AHR pathway. Environ Sci Pollut Res Int 21:13898-908
Clark, Bryan W; Cooper, Ellen M; Stapleton, Heather M et al. (2013) Compound- and mixture-specific differences in resistance to polycyclic aromatic hydrocarbons and PCB-126 among Fundulus heteroclitus subpopulations throughout the Elizabeth River estuary (Virginia, USA). Environ Sci Technol 47:10556-66

Showing the most recent 10 out of 81 publications