Environmental Health Sciences at the University of Arizona has a long-standing reputation for excellence in training Ph.D. and postdoctoral scientists, as evidenced by the fact that many of our graduates are leaders in academia, industry, and government. To this end, our graduate program has evolved from a systems-based toxicology experience to a curriculum in which students are trained to apply state-of-the art techniques to solve mechanisms of environmental toxicity affecting human diseases in various organ systems. The cutting-edge research programs of 30 Training Grant Faculty members are augmented by innovative technologies developed at the University of Arizona in association with the Southwest Environmental Health Sciences and BIO5 Centers. Additionally, translational approaches undertaken by our NIEHS Superfund Program and Dean Carter Binational Center for Environmental Sciences and Toxicology provide an exceptionally stimulating environment for the training of graduate students and postdoctoral fellows. The interactive research of our Training Grant Faculty and our state-of-the-art Facility Cores extend the training environment from a single laboratory-oriented domain to a multidisciplinary experience strongly supportive of collaborative research. Current trainees are now selected through a University-wide competition and the UA Graduate College provides financial support for all first year Ph.D. students through an umbrella recruitment program, providing a large pool of highly qualified candidates for competitive selection of predoctoral trainees. Predoctoral training is achieved through a combination of coursework, laboratory research, and supplemental enrichment activities. Postdoctoral trainees participate in innovative research programs and are guided to develop professional skills in oral and written communication and leadership. Over the past five years, our curricular changes have paralleled the evolving expertise of the Training Grant Faculty. We have recruited eight senior full Professors, three Associate Professors, and seven junior Assistant Professors into the Training Grant, which significantly enhanced our core strengths in mechanistic-based molecular toxicology training. The request for continuation of NIEHS support is justified by the highly successful nature of our program, the clear demand for our graduates, the strong emphasis we place on leadership skills for our trainees and postdoctoral fellows, the increasing number of students interested in toxicology and environmental health, substantial institutional commitment, the strong and well- funded research programs of our faculty, and the excellence of the training environment.

Public Health Relevance

This program is to train the future leaders in environmental toxicology who facilitate the discovery of how environmental exposures affect human health and disease. Our program focuses on mechanistic molecular toxicology and translational applications to human disease that utilize an outstanding training environment to develop exceptional environmental health science researchers.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Institutional National Research Service Award (T32)
Project #
5T32ES007091-37
Application #
9928447
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol A
Project Start
1979-07-01
Project End
2024-06-30
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
37
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Arizona
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
806345617
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Griggs, Chanel A; Malm, Scott W; Jaime-Frias, Rosa et al. (2018) Valproic acid disrupts the oscillatory expression of core circadian rhythm transcription factors. Toxicol Appl Pharmacol 339:110-120
Malm, S W; Amouzougan, E A; Klimecki, W T (2018) Fetal bovine serum induces sustained, but reversible, epithelial-mesenchymal transition in the BEAS-2B cell line. Toxicol In Vitro 50:383-390
Rojo de la Vega, Montserrat; Zhang, Donna D; Wondrak, Georg T (2018) Topical Bixin Confers NRF2-Dependent Protection Against Photodamage and Hair Graying in Mouse Skin. Front Pharmacol 9:287
Dzierlenga, Anika L; Cherrington, Nathan J (2018) Misregulation of membrane trafficking processes in human nonalcoholic steatohepatitis. J Biochem Mol Toxicol 32:e22035
Lee, Sang C; Zhang, Jack; Strom, Josh et al. (2017) G-Quadruplex in the NRF2 mRNA 5' Untranslated Region Regulates De Novo NRF2 Protein Translation under Oxidative Stress. Mol Cell Biol 37:
Rojo de la Vega, Montserrat; Krajisnik, Andrea; Zhang, Donna D et al. (2017) Targeting NRF2 for Improved Skin Barrier Function and Photoprotection: Focus on the Achiote-Derived Apocarotenoid Bixin. Nutrients 9:
Justiniano, Rebecca; Williams, Joshua D; Perer, Jessica et al. (2017) The B6 -vitamer Pyridoxal is a Sensitizer of UVA-induced Genotoxic Stress in Human Primary Keratinocytes and Reconstructed Epidermis. Photochem Photobiol 93:990-998
Tillotson, Joseph; Kedzior, Magdalena; GuimarĂ£es, Larissa et al. (2017) ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A. Bioorg Med Chem Lett 27:4082-4085
Han, JianHua; Dzierlenga, Anika L; Lu, Zhengqiang et al. (2017) Metabolomic profiling distinction of human nonalcoholic fatty liver disease progression from a common rat model. Obesity (Silver Spring) 25:1069-1076
Li, Hui; Clarke, John D; Dzierlenga, Anika L et al. (2017) In vivo cytochrome P450 activity alterations in diabetic nonalcoholic steatohepatitis mice. J Biochem Mol Toxicol 31:

Showing the most recent 10 out of 231 publications