This is a competing renewal application for an environmental pathology training program for 7 predoctoral (PhD) and 2 postdoctoral fellows (MD, DVM, PhD). The investigators will also provide 3 summer fellowships for medical students interested in gaining experience in environmentally oriented research. Since the inception of the training program in 1982, 39 pre-doctoral students have received their Ph.D. degrees while in the program and 25 postdoctoral fellows (M.D.s, D.V.M.s, Ph.D.s) have finished training. These trainees have been recruited to academia, government and industry. A total of 23 highly interactive faculty members from 7 different departments participate in the program. All have funded research programs and are nationally recognized in disciplines related to environmental pathology. The investigators? program emphasizes concepts of basic pathology and """"""""state-of-the-art"""""""" approaches such as computer-assisted teaching (CATS) in environmental pathology, cell imaging, and molecular and cellular approaches for studying mechanisms of environmental disease. Strongly interactive programs exist in mechanisms of DNA damage and repair, cell signaling and control of mitogenesis and cell death. A Howard Hughes Medical Institute (HHMI) research award to the Medical College for establishment of a program in structural biology, long-standing NSF, EPSCoR and HHMI Helix grants with mentoring programs for high school teachers, junior faculty members, undergraduate women and minorities, an NCI-funded comprehensive Cancer Center grant, a Center of Biomedical Research Excellence (COBRE) in Translational Research in Lung Biology and Disease, complementary training programs in Cancer Biology/ Cardiovascular Disease, and an NIH-funded DEVELOP (Delaware-Vermont Linkage to Open the Pipeline) grant to encourage minority students to enter their training program are strengths at UVM. Other strong aspects of the investigators? program include its multi-departmental participation, its Environmental Pathology and Cell Signaling Seminar series, a Cell Imaging Facility, and a new program project grant on """"""""Signaling in Epithelial Injury, Proliferation, and Fibrosis"""""""" in models of asbestosis and asthma.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Institutional National Research Service Award (T32)
Project #
5T32ES007122-22
Application #
6604047
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol K
Project Start
1982-07-01
Project End
2007-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
22
Fiscal Year
2003
Total Cost
$367,989
Indirect Cost
Name
University of Vermont & St Agric College
Department
Pathology
Type
Schools of Medicine
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code
05405
Sayan, Mutlay; Mossman, Brooke T (2016) The NLRP3 inflammasome in pathogenic particle and fibre-associated lung inflammation and diseases. Part Fibre Toxicol 13:51
Cruz, Fernanda F; Borg, Zachary D; Goodwin, Meagan et al. (2016) CD11b+ and Sca-1+ Cells Exert the Main Beneficial Effects of Systemically Administered Bone Marrow-Derived Mononuclear Cells in a Murine Model of Mixed Th2/Th17 Allergic Airway Inflammation. Stem Cells Transl Med 5:488-99
Fang, Pengfei; Yu, Xue; Jeong, Seung Jae et al. (2015) Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase. Nat Commun 6:6402
Lathrop, M J; Sage, E K; Macura, S L et al. (2015) Antitumor effects of TRAIL-expressing mesenchymal stromal cells in a mouse xenograft model of human mesothelioma. Cancer Gene Ther 22:44-54
Mirando, Adam C; Fang, Pengfei; Williams, Tamara F et al. (2015) Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor. Sci Rep 5:13160
Jordan, Christian S; Morrical, Scott W (2015) Regulation of the bacteriophage T4 Dda helicase by Gp32 single-stranded DNA-binding protein. DNA Repair (Amst) 25:41-53
Cruz, Fernanda F; Borg, Zachary D; Goodwin, Meagan et al. (2015) Systemic Administration of Human Bone Marrow-Derived Mesenchymal Stromal Cell Extracellular Vesicles Ameliorates Aspergillus Hyphal Extract-Induced Allergic Airway Inflammation in Immunocompetent Mice. Stem Cells Transl Med 4:1302-16
Cunniff, Brian; Newick, Kheng; Nelson, Kimberly J et al. (2015) Disabling Mitochondrial Peroxide Metabolism via Combinatorial Targeting of Peroxiredoxin 3 as an Effective Therapeutic Approach for Malignant Mesothelioma. PLoS One 10:e0127310
Chapman, David G; Tully, Jane E; Nolin, James D et al. (2014) Animal models of allergic airways disease: where are we and where to next? J Cell Biochem 115:2055-64
Westbom, Catherine M; Shukla, Anurag; MacPherson, Maximilian B et al. (2014) CREB-induced inflammation is important for malignant mesothelioma growth. Am J Pathol 184:2816-27

Showing the most recent 10 out of 73 publications