The multidisciplinary Environmental and Integrative Toxicological Sciences (EITS) Training Program at MSU produces scientists having a base knowledge in environmental toxicology coupled with research expertise gained in a biomedical basic science graduate program. Pre-doctoral trainees must meet the full Ph.D. requirements of their partnering biomedical doctoral program and complete the coursework, research and interactive aspects of the EITS Doctoral Program administered through the Center for Integrative Toxicology (CIT). The dual nature of the training is recognized in the biomedical science-environmental toxicology title of the degree awarded (e.g., Ph.D. in Biochemistry and Molecular Biology-Environmental Toxicology). Graduates of the program are well equipped to conduct research and interact with other scientists in the course of solving complex environmental toxicological problems that require collaborative, multidisciplinary approaches. Twenty-three training faculty members conduct pre-doctoral training in eight basic science Ph.D. programs (Pharmacology/Toxicology, Genetics, Biochemistry and Molecular Biology, Food Science, Cell and Molecular Biology, Comparative Medicine and Integrative Biology, Microbiology and Molecular Genetics, Neuroscience). Added to the basic biomedical science-based education and environmental toxicology research training are didactic, toxicology-oriented courses and other requirements of the EITS Program. This coursework and less formal multidisciplinary interactions and activities provided by the CIT impart a wider scope of knowledge than is available within basic science programs alone. Research topics for trainees span various organ systems and encompass gene-environment interactions and the role of environmental factors in disease susceptibility and progression. There is an integrative biology emphasis to the research training, which emphasizes whole animal, cell-based, molecular and genomic methodologies to understand mechanisms of toxicity in a collaborative atmosphere. The postdoctoral training program involves not only conducting research in the laboratories of the training faculty but also gaining additional environmental toxicology experience and career- building training by following an individual development plan (IDP) and through participation in CIT and University-wide activities. This application is for support of seven pre-doctoral and two postdoctoral trainees, thereby continuing a highly effective multidisciplinary and interactive training program that combines formal and informal approaches to prepare graduates for leadership roles in research in the field of environmental toxicology.

Public Health Relevance

Exposure to various agents in the environment can cause illness directly or exacerbate disease caused by other factors. Reducing the impact of such exposures on human health and devising effective interventions requires public health officials and scientists trained in several areas, including scientists equipped to study and understand mechanisms by which chemical agents cause or exacerbate illness. This Program employs an excellent, research-intensive faculty experienced in doctoral and postdoctoral training in a collaborative environment to train scientists to address toxicological mechanisms of environmental concern.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Institutional National Research Service Award (T32)
Project #
5T32ES007255-29
Application #
9307838
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol A
Project Start
1989-07-01
Project End
2019-06-30
Budget Start
2017-07-01
Budget End
2018-06-30
Support Year
29
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Michigan State University
Department
Pharmacology
Type
Schools of Veterinary Medicine
DUNS #
193247145
City
East Lansing
State
MI
Country
United States
Zip Code
48824
Nault, Rance; Doskey, Claire M; Fader, Kelly A et al. (2018) Comparison of Hepatic NRF2 and Aryl Hydrocarbon Receptor Binding in 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Treated Mice Demonstrates NRF2-Independent PKM2 Induction. Mol Pharmacol 94:876-884
Henriquez, Joseph E; Rizzo, Michael D; Crawford, Robert B et al. (2018) Interferon-?-Mediated Activation of T Cells from Healthy and HIV-Infected Individuals Is Suppressed by ?9-Tetrahydrocannabinol. J Pharmacol Exp Ther 367:49-58
Chen, Chen; Mitchell, Nicole J; Gratz, Jean et al. (2018) Exposure to aflatoxin and fumonisin in children at risk for growth impairment in rural Tanzania. Environ Int 115:29-37
Dornbos, Peter; LaPres, John J (2018) Incorporating population-level genetic variability within laboratory models in toxicology: From the individual to the population. Toxicology 395:1-8
Veiga-Lopez, Almudena; Pu, Yong; Gingrich, Jeremy et al. (2018) Obesogenic Endocrine Disrupting Chemicals: Identifying Knowledge Gaps. Trends Endocrinol Metab 29:607-625
Rizzo, Michael D; Crawford, Robert B; Henriquez, Joseph E et al. (2018) HIV-infected cannabis users have lower circulating CD16+ monocytes and IFN-?-inducible protein 10 levels compared with nonusing HIV patients. AIDS 32:419-429
Henriquez, Joseph E; Rizzo, Michael D; Schulz, Matthias A et al. (2017) ?9-Tetrahydrocannabinol Suppresses Secretion of IFN? by Plasmacytoid Dendritic Cells From Healthy and HIV-Infected Individuals. J Acquir Immune Defic Syndr 75:588-596
Rockwell, Cheryl E; Turley, Alexandra E; Cheng, Xingguo et al. (2017) Persistent alterations in immune cell populations and function from a single dose of perfluorononanoic acid (PFNA) in C57Bl/6 mice. Food Chem Toxicol 100:24-33
Bailey, Jordan M; Colón-Rodríguez, Alexandra; Atchison, William D (2017) Evaluating a Gene-Environment Interaction in Amyotrophic Lateral Sclerosis: Methylmercury Exposure and Mutated SOD1. Curr Environ Health Rep 4:200-207
Mitchell, Nicole J; Riley, Ronald T; Egner, Patricia A et al. (2017) Chronic aflatoxin exposure in children living in Bhaktapur, Nepal: Extension of the MAL-ED study. J Expo Sci Environ Epidemiol 27:106-111

Showing the most recent 10 out of 107 publications