The objective of this interdisciplinary program is to educate a new generation of environmental pathologists to use the tools of cell biology, molecular biology, and biochemistry to study basic mechanisms of disease related to environmental and occupational exposures. The central focus is an independent laboratory research project to explore the pathogenesis of altered reproductive or immune function, neurodegenerative disease, or cancer resulting from exposure to reactive chemicals and oxidants, endocrine disrupting agents, metals, mineral fibers or stress. Pre-doctoral trainees will be recruited with majors in biology, chemistry, toxicology, or environmental sciences and commitment to basic research on mechanisms of disease. Postdoctoral trainees may hold doctoral degrees in a basic science discipline, pathology, or toxicology. All pre-doctoral trainees are required to learn the basic mechanisms and morphologic manifestations of disease in a general pathology course. Training is also provided in molecular pathology, imaging, genetic toxicology, immunopathology, environmental toxicology, epidemiology and biostatistics, carcinogenesis, and molecular genetics. All trainees will be instructed in the responsible conduct of research and will have the opportunity to develop their communication and teaching skills at the Sheridan Center for Teaching and Learning at Brown University. Didactic courses are supplemented by weekly research seminars, student journal clubs, career development workshops, and an annual Environmental Pathology Symposium. Strong emphasis is placed on communication skills, grantsmanship, interdisciplinary approaches, and implications of basic research on regulatory and public policy decisions. Continuing support is requested for four pre-doctoral and two postdoctoral trainees. The ten faculty have active, well-funded research programs ($2.5 million in annual direct costs) and access to modem research facilities equipped for quantitative imaging and morphometry, laser scanning confocal microscopy, laser capture microdissection, mass-spectroscopy, microarray analysis, flow cytometry, and transgenic animals.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Institutional National Research Service Award (T32)
Project #
5T32ES007272-12
Application #
6604053
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol K
Project Start
1992-07-01
Project End
2007-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
12
Fiscal Year
2003
Total Cost
$245,244
Indirect Cost
Name
Brown University
Department
Pathology
Type
Schools of Medicine
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912
Dere, Edward; Anderson, Linnea M; Huse, Susan M et al. (2018) Effects of continuous bisphenol A exposure from early gestation on 90?day old rat testes function and sperm molecular profiles: A CLARITY-BPA consortium study. Toxicol Appl Pharmacol 347:1-9
Patel, Mohak; Leggett, Susan E; Landauer, Alexander K et al. (2018) Rapid, topology-based particle tracking for high-resolution measurements of large complex 3D motion fields. Sci Rep 8:5581
Valentin, Thomas M; Leggett, Susan E; Chen, Po-Yen et al. (2017) Stereolithographic printing of ionically-crosslinked alginate hydrogels for degradable biomaterials and microfluidics. Lab Chip 17:3474-3488
Rodd, April L; Messier, Norma J; Vaslet, Charles A et al. (2017) A 3D fish liver model for aquatic toxicology: Morphological changes and Cyp1a induction in PLHC-1 microtissues after repeated benzo(a)pyrene exposures. Aquat Toxicol 186:134-144
Foster, Melanie L; Bartnikas, Thomas B; Maresca-Fichter, Hailey C et al. (2017) Interactions of manganese with iron, zinc, and copper in neonatal C57BL/6J and parkin mice following developmental oral manganese exposure. Data Brief 15:908-915
Dai, M S; Hall, S J; Vantangoli Policelli, M M et al. (2017) Spontaneous testicular atrophy occurs despite normal spermatogonial proliferation in a Tp53 knockout rat. Andrology 5:1141-1152
Leggett, Susan E; Khoo, Amanda S; Wong, Ian Y (2017) Multicellular tumor invasion and plasticity in biomimetic materials. Biomater Sci 5:1460-1479
Leggett, Susan E; Wong, Ian Y (2017) Nanomedicine: Catching tumour cells in the zone. Nat Nanotechnol 12:191-193
Vantangoli, Marguerite M; Madnick, Samantha J; Wilson, Shelby et al. (2016) Estradiol Exposure Differentially Alters Monolayer versus Microtissue MCF-7 Human Breast Carcinoma Cultures. PLoS One 11:e0157997
Wang, Zhongying; Tonderys, Daniel; Leggett, Susan E et al. (2016) Wrinkled, wavelength-tunable graphene-based surface topographies for directing cell alignment and morphology. Carbon N Y 97:14-24

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