The objective of this application is to provide the information required to maintain continuity of our program of predoctoral and postdoctoral training in vision science at the Jules Stein Eye Institute of the University of California, Los Angeles. Trainees working in several fields of basic research applied to the eye will be exposed to an organized curriculum of courses, seminars and conferences, and will be instructed in the techniques and practical aspects of laboratory research. The research training will take place in one or more of the laboratories of the preceptors of this grant, who are all members of the Jules Stein Eye Institute at UCLA. Trainees will also be exposed to principles and standards of responsible conduct of research. Predoctoral trainees interested in vision research will be selected from among students accepted into the UCLA graduate programs (ACCESS, Neuroscience or individual departmental programs) on the basis of previous academic performance, strength of letters of recommendation, and demonstrated aptitude for doing research. We are requesting 7 predoctoral positions per year, with an expected duration of support of 3 to 4 years for each. Postdoctoral trainees (5 one-year positions/year) will be chosen on the basis of the applicant's past performance, letters of reference from department chairmen, previous preceptors and research advisors, potential for future contributions to vision science and commitment to research of direct relevance to the recommendations of the National Advisory Eye Council. Special emphasis will be placed on the recruitment of underrepresented minorities. Research in the basic sciences at the Jules Stein Eye Institute is focused on the anatomy, biochemistry, biophysics, chemistry, molecular biology, genetics, neuroscience, physiology, pharmacology, and cell biology of the retina, lens, cornea and ciliary body. In addition, areas of basic science with immediate applicability to the clinic include corneal immunology, etiology of strabismus and other eye movement disorders, the molecular biology, genetics, epidemiology and gene therapy of retinal degenerations and macular disease, the role of heat shock proteins in ganglion cells of an animal model of glaucoma in neuro-protection, the molecular mechanisms controlling vertebrate eye development and the proteins of tears. Upon completion of this program, trainees will be able to compete effectively for academic positions in basic and clinical departments and for independent R01 funding in eye research. ? ?

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Institutional National Research Service Award (T32)
Project #
2T32EY007026-31
Application #
6894563
Study Section
Special Emphasis Panel (ZEY1-VSN (04))
Program Officer
Hunter, Chyren
Project Start
1975-07-01
Project End
2010-09-29
Budget Start
2005-09-30
Budget End
2006-09-29
Support Year
31
Fiscal Year
2005
Total Cost
$324,710
Indirect Cost
Name
University of California Los Angeles
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Stadtmueller, Beth M; Bridges, Michael D; Dam, Kim-Marie et al. (2018) DEER Spectroscopy Measurements Reveal Multiple Conformations of HIV-1 SOSIP Envelopes that Show Similarities with Envelopes on Native Virions. Immunity 49:235-246.e4
Gu, Xin; Bridges, Michael D; Yan, Yan et al. (2018) Conformational heterogeneity of the allosteric drug and metabolite (ADaM) site in AMP-activated protein kinase (AMPK). J Biol Chem 293:16994-17007
Wang, Yuchen; Fehlhaber, Katherine E; Sarria, Ignacio et al. (2017) The Auxiliary Calcium Channel Subunit ?2?4 Is Required for Axonal Elaboration, Synaptic Transmission, and Wiring of Rod Photoreceptors. Neuron 93:1359-1374.e6
Williams, D S; Chadha, A; Hazim, R et al. (2017) Gene therapy approaches for prevention of retinal degeneration in Usher syndrome. Gene Ther 24:68-71
Young, Alejandra; Dandekar, Uma; Pan, Calvin et al. (2016) GNAI3: Another Candidate Gene to Screen in Persons with Ocular Albinism. PLoS One 11:e0162273
Vuong, Helen E; Hardi, Claudia N; Barnes, Steven et al. (2015) Parallel Inhibition of Dopamine Amacrine Cells and Intrinsically Photosensitive Retinal Ganglion Cells in a Non-Image-Forming Visual Circuit of the Mouse Retina. J Neurosci 35:15955-70
Le, Alan; Poukens, Vadims; Ying, Howard et al. (2015) Compartmental Innervation of the Superior Oblique Muscle in Mammals. Invest Ophthalmol Vis Sci 56:6237-46
Cao, Yan; Sarria, Ignacio; Fehlhaber, Katherine E et al. (2015) Mechanism for Selective Synaptic Wiring of Rod Photoreceptors into the Retinal Circuitry and Its Role in Vision. Neuron 87:1248-1260
Vuong, H E; Pérez de Sevilla Müller, L; Hardi, C N et al. (2015) Heterogeneous transgene expression in the retinas of the TH-RFP, TH-Cre, TH-BAC-Cre and DAT-Cre mouse lines. Neuroscience 307:319-37
Cui, Xinhan; Hong, Jiaxu; Wang, Fei et al. (2014) Assessment of corneal epithelial thickness in dry eye patients. Optom Vis Sci 91:1446-54

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