The Training Program in Genetics and Development is a vigorous predoctoral training program designed to train young scientists for productive research careers. The goals are 1) to provide a solid and broad education in genetics, including molecular genetics, developmental genetics, and human genetics; and 2) to provide rigorous training in biomedical research. The program emphasizes experimental skills and critical thinking. Trainees are drawn from all parts of the United States and around the world and usually have a BA or BS degree. There are currently 41 trainees working toward the Ph.D. degree with an expected time to completion of 4-6 years. We typically admit 9 students per year. Immediately upon entry into the program, students begin training in the design of experiments and the proper evaluation of data, along with their didactic training. Skills in written and oral presentation are developed both in classes and in research settings. The educational strength of the program relies on the strength of the faculty. During the past 5 years, several outstanding faculty have been recruited to the program. Research areas include the regulation of gene expression and growth control in eukaryotic cells, the molecular genetics of cell differentiation and development, the genetics and pathogenesis of inherited disease, the molecular genetics of cancer, animal models for human genetic disease, human gene therapy, the genetics of recombination and linkage analysis. Another major strength of the program is the stimulating research environment in New York City and at the Health Sciences Campus of Columbia University. The research community encompasses many interactive departments and research institutes. Participation in the larger national and international scientific community thrives through the many excellent seminar series on campus. Core equipment and services are available, there is an outstanding biomedical library, and computer services and animal facilities are excellent.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
2T32GM007088-27
Application #
6313738
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Rhoades, Marcus M
Project Start
1975-07-01
Project End
2006-06-30
Budget Start
2001-07-01
Budget End
2002-06-30
Support Year
27
Fiscal Year
2001
Total Cost
$299,288
Indirect Cost
Name
Columbia University (N.Y.)
Department
Genetics
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Smith, Michael J; Bryant, Eric E; Rothstein, Rodney (2018) Increased chromosomal mobility after DNA damage is controlled by interactions between the recombination machinery and the checkpoint. Genes Dev 32:1242-1251
Rastogi, Chaitanya; Rube, H Tomas; Kribelbauer, Judith F et al. (2018) Accurate and sensitive quantification of protein-DNA binding affinity. Proc Natl Acad Sci U S A 115:E3692-E3701
Dugger, Sarah A; Platt, Adam; Goldstein, David B (2018) Drug development in the era of precision medicine. Nat Rev Drug Discov 17:183-196
Lau, Colleen M; Tiniakou, Ioanna; Perez, Oriana A et al. (2018) Transcription factor Etv6 regulates functional differentiation of cross-presenting classical dendritic cells. J Exp Med 215:2265-2278
Manterola, Marcia; Brown, Taylor M; Oh, Min Young et al. (2018) BRDT is an essential epigenetic regulator for proper chromatin organization, silencing of sex chromosomes and crossover formation in male meiosis. PLoS Genet 14:e1007209
Kirkling, Margaret E; Cytlak, Urszula; Lau, Colleen M et al. (2018) Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells. Cell Rep 23:3658-3672.e6
Hirsch, Sophia M; Sundaramoorthy, Sriramkumar; Davies, Tim et al. (2018) FLIRT: fast local infrared thermogenetics for subcellular control of protein function. Nat Methods 15:921-923
Concepcion, Daniel; Hamada, Hiroshi; Papaioannou, Virginia E (2018) Tbx6 controls left-right asymmetry through regulation of Gdf1. Biol Open 7:
O'Connor, Reed M; Stone, Elizabeth F; Wayne, Charlotte R et al. (2017) A Drosophila model of Fragile X syndrome exhibits defects in phagocytosis by innate immune cells. J Cell Biol 216:595-605
De Tullio, Luisina; Kaniecki, Kyle; Kwon, Youngho et al. (2017) Yeast Srs2 Helicase Promotes Redistribution of Single-Stranded DNA-Bound RPA and Rad52 in Homologous Recombination Regulation. Cell Rep 21:570-577

Showing the most recent 10 out of 97 publications