Abstract

The present proposal requests funding for years thirty five through forty for the Pharmacological Sciences Training Program at Duke University. The goal of this training program is to prepare Ph.D. candidates from a variety of disciplines to use Pharmacology in their careers as active research scientists in leadership roles. Trainees in the program are pre-doctoral students in biomedical sciences. The program provides classroom training in the basic principles of drug action from the molecular to organismal level and the application of these principles to the treatment of human disease. The research component trains students to conduct cutting-edge research in an area relevant to Pharmacology. Throughout both the classroom and research phase of the pre-doctoral program, trainees participate in research retreats, receive mentoring and ethics training and professional development opportunities. The program requests funding for 2 years of pre-doctoral graduate studies for 10 trainees.

Public Health Relevance

The goal of this training is to prepare Ph.D. candidates to participate in the field of Pharmacology. Graduates of this program will be able to invent new medicines, study the adverse effects of current medicines and develop an understanding of disease and how to treat it.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM007105-39
Application #
8496041
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Okita, Richard T
Project Start
1975-07-01
Project End
2015-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
39
Fiscal Year
2013
Total Cost
$446,546
Indirect Cost
$21,226

  Institution

Name
Duke University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705

  Publications

Trub, Alec G; Hirschey, Matthew D (2018) Reactive Acyl-CoA Species Modify Proteins and Induce Carbon Stress. Trends Biochem Sci 43:369-379
Schulte, Michael L; Fu, Allie; Zhao, Ping et al. (2018) Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models. Nat Med 24:194-202
Short, Melanie A; Blackburn, J Miles; Roizen, Jennifer L (2018) Sulfamate Esters Guide Selective Radical-Mediated Chlorination of Aliphatic C-H Bonds. Angew Chem Int Ed Engl 57:296-299
Posfai, Dora; Eubanks, Amber L; Keim, Allison I et al. (2018) Identification of Hsp90 Inhibitors with Anti-Plasmodium Activity. Antimicrob Agents Chemother 62:
Adamson, Nathan J; Wilbur, Katherine C E; Malcolmson, Steven J (2018) Enantioselective Intermolecular Pd-Catalyzed Hydroalkylation of Acyclic 1,3-Dienes with Activated Pronucleophiles. J Am Chem Soc 140:2761-2764
Scarneo, Scott A; Mansourati, Antoine; Eibschutz, Liesl S et al. (2018) Genetic and pharmacological validation of TAK1 inhibition in macrophages as a therapeutic strategy to effectively inhibit TNF secretion. Sci Rep 8:17058
Hartman, Jessica H; Smith, Latasha L; Gordon, Kacy L et al. (2018) Swimming Exercise and Transient Food Deprivation in Caenorhabditis elegans Promote Mitochondrial Maintenance and Protect Against Chemical-Induced Mitotoxicity. Sci Rep 8:8359
Allen, Annamarie E; Locasale, Jason W (2018) Glucose Metabolism in Cancer: The Saga of Pyruvate Kinase Continues. Cancer Cell 33:337-339
Zaengle-Barone, Jacqueline M; Jackson, Abigail C; Besse, David M et al. (2018) Copper Influences the Antibacterial Outcomes of a ?-Lactamase-Activated Prochelator against Drug-Resistant Bacteria. ACS Infect Dis 4:1019-1029
Cervia, Lisa D; Chang, Chun-Chi; Wang, Liangli et al. (2018) Enhancing Electrotransfection Efficiency through Improvement in Nuclear Entry of Plasmid DNA. Mol Ther Nucleic Acids 11:263-271

Showing the most recent 10 out of 84 publications