The University of Pennsylvania MSTP is currently in its 32nd year of continuous funding, and is the only one providing support for both MD-Ph.D. and VMD-Ph.D. trainees. The goal of the program is to identify, train and mentor outstanding men and women who will become teachers, scholars, and the leaders of biomedical and veterinary research. To accomplish this goal, we have established training plans that emphasize the integration of the two degrees in preparation for careers that will make use of both. The large institutional commitment to this goal is reflected by the sizeable investment that the medical and veterinary schools have made in this program, providing it with resources that are used to help cover tuition and stipends costs, provide enrichment activities and support administration of the program. In the current year there are 153 MD-Ph.D. and 21 VMD-Ph.D. trainees at Penn, 101 of whom have been supported in part by this grant. They are a talented and diverse group of individuals. Approximately 38% are women and 13% are members of underrepresented minority groups. The selection process emphasizes academic excellence, relevant research experience, creativity, letters of recommendation and a well-articulated plan for a career in biomedical investigation. Most trainees do graduate work in the biomedical laboratory sciences, but 10% of our trainees are enrolled in Biomedical Engineering, Health Care Economics (Wharton), History &Sociology of Science, and Epidemiology. On the alumni side, there have been 354 MD-Ph.D. graduates and 52 VMD-Ph.D. graduates thru AY 2006. Follow-up information on essentially all of them is included in the proposal. Approximately 80% of the MD-Ph.D. alumni and 80% of VMD-Ph.D. alumni who have completed postgraduate training are doing research in academic centers, institutes or industry. Many have NIH or other extramural funding for their research. Very few have entered private practice, an outcome considered contrary to the aims of both training programs. Many are on the faculty of universities and research institutes. Based on this track record, our goals for the future include 1) continued growth of the program to reach a steady state of 160-170 MD-Ph.D. and at least 40 VMD-Ph.D. students, 2) further integration of the graduate and professional degrees, 3) a continued emphasis on attracting and training individuals who are uniquely well prepared for careers in the discovery and application of new knowledge through basic, translational and patient-oriented research, and 4) participation in the development at Penn of postgraduate programs that will help MD-Ph.D. and VMD-Ph.D. graduates make a successful transition to independent investigators.
| Lewis, Emma L; Sierra, Luz-Jeannette; Barila, Guillermo O et al. (2018) Placental immune state shifts with gestational age. Am J Reprod Immunol 79:e12848 |
| Chadwick, Alexandra C; Evitt, Niklaus H; Lv, Wenjian et al. (2018) Reduced Blood Lipid Levels With In Vivo CRISPR-Cas9 Base Editing of ANGPTL3. Circulation 137:975-977 |
| Becker, Nora V; Gibbins, Karen J; Perrone, Jeanmarie et al. (2018) Geographic variation in postpartum prescription opioid use: Opportunities to improve maternal safety. Drug Alcohol Depend 188:288-294 |
| Kim, Yong Hoon; Marhon, Sajid A; Zhang, Yuxiang et al. (2018) Rev-erb? dynamically modulates chromatin looping to control circadian gene transcription. Science 359:1274-1277 |
| Carey, Jeffrey N; Mettert, Erin L; Roggiani, Manuela et al. (2018) Regulated Stochasticity in a Bacterial Signaling Network Permits Tolerance to a Rapid Environmental Change. Cell 173:196-207.e14 |
| Thalji, Nabil K; Camire, Rodney M (2017) Rendering factor Xa zymogen-like as a therapeutic strategy to treat bleeding. Curr Opin Hematol 24:453-459 |
| Poleshko, Andrey; Shah, Parisha P; Gupta, Mudit et al. (2017) Genome-Nuclear Lamina Interactions Regulate Cardiac Stem Cell Lineage Restriction. Cell 171:573-587.e14 |
| Freund-Brown, Jacquelyn; Choa, Ruth; Singh, Brenal K et al. (2017) Cutting Edge: Murine NK Cells Degranulate and Retain Cytotoxic Function without Store-Operated Calcium Entry. J Immunol : |
| Mellis, Ian A; Gupte, Rohit; Raj, Arjun et al. (2017) Visualizing adenosine-to-inosine RNA editing in single mammalian cells. Nat Methods 14:801-804 |
| Brandstadter, Joshua D; Chen, Huiyao; Jiang, Songfu et al. (2017) IL-18-dependent NKG2D ligand upregulation on accessory cells is mediated by the PI3K/GSK-3 pathway. J Leukoc Biol 101:1317-1323 |
Showing the most recent 10 out of 239 publications
