The Cell, Molecular, and Genetics (CMG) Training Program at the University of California, San Diego is currently in its 25th year. This program is the foundation of the Ph.D. training effort in the biological sciences at UCSD, as it supports the very best graduate students from the Biology-Salk and Chemistry-Biochemistry Ph.D. programs. The mission of the CMG Training Program is to provide rigorous basic research training in cell biology, molecular biology, and genetics to outstanding young biomedical researchers in the earlier years of their doctoral studies. Specific emphasis is placed upon the creativity, quality, and impact of the research, the ethical conduct of research, the achievement of racial diversity among biomedical researchers, the ability of the trainees to communicate their results effectively, and the promotion of cooperation and collaboration among scientists. While the new director has already made an impressive impact and demonstrates significant potential for leading this program to a greater level of accomplishment, more time is needed to correct the weaknesses mentioned above. Thus, funding for three years at the current slot level is recommended to provide for a timelier reassessment of progress. The CMG Program Director is Dr. Jim Kadonaga. He has been a member of the Biology Department/Division at UCSD since 1988, and is currently Professor and Vice Chair of the Molecular Biology Section. Dr. Kadonaga works with an Advisory Committee for the CMG Training Program that consists of Drs. Lorraine Pillus, Steve Wasserman, Bart Sefton, Elizabeth Komives, and Bill McGinnis. There are currently 98 training faculty from the UCSD Division of Biology, Salk Institute, UCSD Department of Chemistry and Biochemistry, and Department of Cellular and Molecular Medicine at the UCSD Medical School. The CMG Training Program provides support for 45 outstanding Ph.D. students that are selected from a five-fold larger pool of eligible students (currently, 224 eligible students). The trainees fulfill the general requirements of their respective graduate programs and additionally participate in CMG-specific training activities, which include biannual CMG Training Program Symposia, annual One-on-One Conferences with the Program Director, and CMG Career Development Workshops. Over the past 10 years, 124 CMG trainees have successfully completed their Ph.D. thesis. Past and present CMG trainees have contributed an enormous wealth of fascinating and important knowledge to the biological sciences through a total of 411 publications (not including abstracts). With the projected growth of biology at UCSD, we envision the implementation of an even stronger CMG Training Program over the next five years.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM007240-27
Application #
6603211
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Zatz, Marion M
Project Start
1975-07-01
Project End
2005-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
27
Fiscal Year
2003
Total Cost
$1,155,821
Indirect Cost
Name
University of California San Diego
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Rahnamoun, Homa; Hong, Juyeong; Sun, Zhengxi et al. (2018) Mutant p53 regulates enhancer-associated H3K4 monomethylation through interactions with the methyltransferase MLL4. J Biol Chem 293:13234-13246
Hagstrom, Danielle; Truong, Lisa; Zhang, Siqi et al. (2018) Comparative analysis of zebrafish and planarian model systems for developmental neurotoxicity screens using an 87-compound library. Toxicol Sci :
Buchwalter, Abigail; Kaneshiro, Jeanae M; Hetzer, Martin W (2018) Coaching from the sidelines: the nuclear periphery in genome regulation. Nat Rev Genet :
Yu, Seungyoon B; Pekkurnaz, Gulcin (2018) Mechanisms Orchestrating Mitochondrial Dynamics for Energy Homeostasis. J Mol Biol 430:3922-3941
Wangeline, Margaret A; Hampton, Randolph Y (2018) ""Mallostery""-ligand-dependent protein misfolding enables physiological regulation by ERAD. J Biol Chem 293:14937-14950
Zuzow, Nathan; Ghosh, Arit; Leonard, Marilyn et al. (2018) Mapping the mammalian ribosome quality control complex interactome using proximity labeling approaches. Mol Biol Cell 29:1258-1269
Banghart, Matthew R; He, Xinyi J; Sabatini, Bernardo L (2018) A Caged Enkephalin Optimized for Simultaneously Probing Mu and Delta Opioid Receptors. ACS Chem Neurosci 9:684-690
Gupta, Naveen; Liu, Roland; Shin, Stephanie et al. (2018) SCH79797 improves outcomes in experimental bacterial pneumonia by boosting neutrophil killing and direct antibiotic activity. J Antimicrob Chemother 73:1586-1594
Petty, Emily L; Evpak, Masha; Pillus, Lorraine (2018) Connecting GCN5's centromeric SAGA to the mitotic tension-sensing checkpoint. Mol Biol Cell 29:2201-2212
Rahnamoun, Homa; Lee, Jihoon; Sun, Zhengxi et al. (2018) RNAs interact with BRD4 to promote enhanced chromatin engagement and transcription activation. Nat Struct Mol Biol 25:687-697

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