This proposal requests continued support for the Medical Scientist Training Program (MSTP) at Vanderbilt University. The Vanderbilt MSTP provides students with a strong medical education and rigorous training in science. The grant supports students at Vanderbilt University and Meharry Medical College. ? ? The 65 students currently enrolled in the program come from 52 colleges representing all regions of the U.S. The applicant pool has more than tripled in the past five years as a result of enhanced recruiting efforts, including those focused specifically on the recruitment of students from underrepresented minority groups. In the current year, 320 applications have been received, from which 10 students will be selected to enter the incoming class. The institution has made a financial commitment to support the growth of the program to a steady state of 75 students over the next five years. This commitment includes a fundraising initiative to establish a $10 million endowment to support the MSTP. Programmatic identity is provided by weekly MSTP seminars, a clinical re-entry exercise, and a summer retreat. The academic program is designed to train leaders in biomedical research. Formal instruction in responsible conduct of research is included in the curriculum. Sixty-nine percent of our graduates with established careers hold academic positions. This includes three deans and 22 full professors. The 30% of graduates still in training are in excellent residencies and fellowships. ? ? The environment for physician-scientist training at Vanderbilt University is outstanding. The institution has 283 fulltime faculty in the basic science departments and 1,056 in the clinical departments. The faculty attracts $122.2 million in federally-sponsored research and $60.9 million in non-federal support. ? ? The proposal requests an increase in support from 20 to 26 (2 for Meharry; 24 for Vanderbilt/Meharry) funded positions during the five year project period. The proposed increase in funded positions will result in an increase in NIH support for the program from the current 31% to 33% in 2008. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM007347-27
Application #
6911693
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Shapiro, Bert I
Project Start
1977-07-01
Project End
2009-06-30
Budget Start
2005-07-01
Budget End
2006-06-30
Support Year
27
Fiscal Year
2005
Total Cost
$900,866
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Harris, Nicholas A; Winder, Danny G (2018) Synaptic Plasticity in the Bed Nucleus of the Stria Terminalis: Underlying Mechanisms and Potential Ramifications for Reinstatement of Drug- and Alcohol-Seeking Behaviors. ACS Chem Neurosci 9:2173-2187
Case, James Brett; Li, Yize; Elliott, Ruth et al. (2018) Murine Hepatitis Virus nsp14 Exoribonuclease Activity Is Required for Resistance to Innate Immunity. J Virol 92:
Berkman, Jillian; Ford, Caleb; Johnson, Emily et al. (2018) Misdiagnosis: CNS Erdheim-Chester disease mimicking CLIPPERS. Neuroradiol J 31:399-402
Harris, Nicholas A; Isaac, Austin T; Günther, Anne et al. (2018) Dorsal BNST ?2A-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors. J Neurosci 38:8922-8942
Watchmaker, Jennifer M; Juttukonda, Meher R; Davis, Larry T et al. (2018) Hemodynamic mechanisms underlying elevated oxygen extraction fraction (OEF) in moyamoya and sickle cell anemia patients. J Cereb Blood Flow Metab 38:1618-1630
Stothers, C L; Luan, L; Fensterheim, B A et al. (2018) Hypoxia-inducible factor-1? regulation of myeloid cells. J Mol Med (Berl) 96:1293-1306
Hartmann, Katherine E; Sundermann, Alexandra C; Helton, Rebecca et al. (2018) The Scope of Extraprofessional Caregiving Challenges Among Early Career Faculty: Findings From a University Medical Center. Acad Med 93:1707-1712
McKenna, Matthew T; Weis, Jared A; Brock, Amy et al. (2018) Precision Medicine with Imprecise Therapy: Computational Modeling for Chemotherapy in Breast Cancer. Transl Oncol 11:732-742
Choksi, Yash A; Reddy, Vishruth K; Singh, Kshipra et al. (2018) BVES is required for maintenance of colonic epithelial integrity in experimental colitis by modifying intestinal permeability. Mucosal Immunol 11:1363-1374
Bloodworth, Melissa H; Rusznak, Mark; Pfister, Connor C et al. (2018) Glucagon-like peptide 1 receptor signaling attenuates respiratory syncytial virus-induced type 2 responses and immunopathology. J Allergy Clin Immunol 142:683-687.e12

Showing the most recent 10 out of 536 publications