The goal of this program is to train graduate students for the PhD degree in the broad and interdisciplinary areas of Cell Biology, Molecular Biology and Genetics. This program includes 52 faculty from 9 basic science departments, and is the only graduate training program at Einstein with this broad and interdisciplinary research emphasis. This renewal application is to continue the program with support for 19 trainees (~6-8 appointed per year). Over the past 10 years, the program has graduated 61 PhD students including 23 under- represented minority students. More than 95% of our graduates have continued in science-related careers. The overall objectives of the program are for students to perform significant basic science research projects, to acquire rigorous scientific background and experimental training, and to develop into independent scientists that make long-term contributions. The program is uniquely suited to train students in the use of a wide variety of cell biology, molecular biology, biochemical and genetic methods to address fundamental basic science questions. It is also ideally positioned to promote interdisciplinary research and quantitative methodologies. Training faculty are selected based on their research excellence in the broad areas of Cell Biology, Molecular Biology and Genetics, and their commitment to mentoring graduate students and to providing an excellent training environment. All but the most junior faculty members have substantial mentoring experience. A number of mechanisms are in place to assist junior faculty in mentoring students and to provide additional oversight for students in their labs. Trainees enter the Einstein Graduate School through a single portal. They complete 2-3 research rotations in the first year and undertake rigorous coursework including several foundation courses taught by our trainers. Students write a grant proposal-type qualifying exam based on their PhD research and defend it orally to an interdisciplinary faculty committee. Students are reviewed by the steering committee after the first and second year of graduate training, and interviewed by the Program Director prior to appointment for 1-3 years of funding. Training program activities are used to build a coherent training effort in which students participate until completion of the PhD. Trainees present yearly in a very active work-in-progress series and host an annual seminar speaker. A yearly program retreat includes talks by more senior students, workshops, and ethics discussions. Alumni from our training program also present in the retreat to provide career perspectives. At these events, our trainers and steering committee, together with the Director, provide input on research directions, presentation skills, and publication strategies. Together, these features make the program a vibrant and highly interactive community of faculty trainers and graduate students involved in key basic science questions that are relevant to human health. Students graduate with the scientific background, research skills, and critical thought process necessary for an independent career in science.

Public Health Relevance

This is a renewal of a training grant that supports pre-doctoral students engaged in research in Cell Biology, Molecular Biology and Genetics. This basic research has many important applications to human health issues including cancer, developmental problems, diabetes, and infectious disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM007491-46
Application #
9994904
Study Section
NIGMS Initial Review Group (TWD)
Program Officer
Gindhart, Joseph G
Project Start
1987-07-01
Project End
2022-06-30
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
46
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Type
DUNS #
081266487
City
Bronx
State
NY
Country
United States
Zip Code
10461
Ruiz, Penelope D; Gamble, Matthew J (2018) MacroH2A1 chromatin specification requires its docking domain and acetylation of H2B lysine 20. Nat Commun 9:5143
Walters, Ryan O; Arias, Esperanza; Diaz, Antonio et al. (2018) Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans. Cell Rep 25:663-676.e6
Mocholi, Enric; Dowling, Samuel D; Botbol, Yair et al. (2018) Autophagy Is a Tolerance-Avoidance Mechanism that Modulates TCR-Mediated Signaling and Cell Metabolism to Prevent Induction of T Cell Anergy. Cell Rep 24:1136-1150
Lázaro-Peña, María I; Díaz-Balzac, Carlos A; Bülow, Hannes E et al. (2018) Synaptogenesis Is Modulated by Heparan Sulfate in Caenorhabditis elegans. Genetics 209:195-208
Zamurrad, Sumaira; Hatch, Hayden A M; Drelon, Coralie et al. (2018) A Drosophila Model of Intellectual Disability Caused by Mutations in the Histone Demethylase KDM5. Cell Rep 22:2359-2369
Zhao, Yingjie; Guo, Tingwei; Fiksinski, Ania et al. (2018) Variance of IQ is partially dependent on deletion type among 1,427 22q11.2 deletion syndrome subjects. Am J Med Genet A 176:2172-2181
Maryanovich, Maria; Zahalka, Ali H; Pierce, Halley et al. (2018) Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche. Nat Med 24:782-791
Carvajal, Luis A; Neriah, Daniela Ben; Senecal, Adrien et al. (2018) Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia. Sci Transl Med 10:
Tu, Vincent; Yakubu, Rama; Weiss, Louis M (2018) Observations on bradyzoite biology. Microbes Infect 20:466-476
Caballero, Benjamin; Wang, Yipeng; Diaz, Antonio et al. (2018) Interplay of pathogenic forms of human tau with different autophagic pathways. Aging Cell 17:

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