This application requests resources to support 40 trainees per year through the Medical Scientist Training Program (MSTP) at the University of California, San Francisco (UCSF). The MSTP has the goal of training the next generation of physician-investigators by offering a rigorous, integrated, and supportive educational experience leading to both M.D. and Ph.D. degrees. The UCSF MSTP offers the combination of an outstanding public medical school with an innovative curriculum, committed and renowned faculty, and a collection of premier graduate training programs. The program is currently in its 37th year of continuous NIH support. From its inception, the guiding principles have been: (1) selecting outstanding students who are committed to careers as physician-investigators and who have the academic ability and interpersonal skills to excel in medicine and science; (2) offering the best possible training leading to combined M.D. and Ph.D. degrees without compromising the quality of training for either degree; and, (3) actively engaging the UCSF School of Medicine (SOM) and Graduate Programs to optimize the training path of each student and to encourage efficient completion of both degrees. During the current period of T32 support, our MSTP has continued to attract and train exceptional students who have a remarkable record of success. The leaders of the SOM have demonstrated an extraordinary level of commitment to the program, which with 98 trainees now enrolled, has reached steady enrollment. New activities to enhance and optimize the training of students have been added during the current period of support. Our trainees have formed a strong community that has engaged the faculty to enhance the training environment at UCSF. The achievements of our students and their subsequent track records underscore the value of this combined degree program. This application is directly relevant to the mission of the NIGMS and NIH as it requests funds to support mentored career development for the next generation of physician-scientists. This MSTP represents an investment in the future of our nation's health as the researchers who are trained through this award will be optimally prepared to harness discovery-based research strategies to attack urgent problems in human health with the goal of developing and implement innovative new treatments.

Public Health Relevance

Attacking complex diseases such as cancer, arthritis, and Alzheimer's dementia will require a new generation of researchers who are both outstanding physicians and skilled scientists who understand how to harness new technologies to advance human health. This application requests continuing support for the Medical Scientist Training Program at the University of California, San Francisco, which is achieving this goal by offering a rigorous, integrated, and supportive program that results in graduates who hold both M.D. and Ph.D. degrees.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM007618-42
Application #
9700654
Study Section
NIGMS Initial Review Group (TWD)
Program Officer
Maas, Stefan
Project Start
1978-07-01
Project End
2021-06-30
Budget Start
2019-07-01
Budget End
2020-06-30
Support Year
42
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Pediatrics
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94118
Ricardo-Gonzalez, Roberto R; Van Dyken, Steven J; Schneider, Christoph et al. (2018) Tissue signals imprint ILC2 identity with anticipatory function. Nat Immunol 19:1093-1099
Wangensteen, Kirk J; Wang, Yue J; Dou, Zhixun et al. (2018) Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform. Hepatology 68:663-676
Lam, Christine; Ferguson, Ian D; Mariano, Margarette C et al. (2018) Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment. Haematologica 103:1218-1228
Fassett, Marlys S; Pua, Heather H; Simpson, Laura J et al. (2018) Identification of Functionally Relevant microRNAs in the Regulation of Allergic Inflammation. Methods Mol Biol 1799:341-351
Yu, Zhou; Surface, Lauren E; Park, Chong Yon et al. (2018) Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates. Elife 7:
Schirmer, Lucas; Möbius, Wiebke; Zhao, Chao et al. (2018) Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity. Elife 7:
Sorrells, Shawn F; Paredes, Mercedes F; Cebrian-Silla, Arantxa et al. (2018) Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. Nature 555:377-381
Cho, Seung Woo; Xu, Jin; Sun, Ruping et al. (2018) Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element. Cell 173:1398-1412.e22
Dang, Eric V; Cyster, Jason G (2018) Loss of sterol metabolic homeostasis triggers inflammasomes?-?how and why. Curr Opin Immunol 56:1-9
Chang, Roger; Eriksen, Jacob; Edwards, Robert H (2018) The dual role of chloride in synaptic vesicle glutamate transport. Elife 7:

Showing the most recent 10 out of 280 publications