This application is to fund four surgical trainees at post graduate year 2 or higher or (occasionally) postdoctoral Ph.D.s for two or three years of scientific training in burns and trauma. A faculty of 20 MD and/or Ph.D.-trained scientists with wide scientific expertise has been chosen to provide wide choice and depth of training. That expertise is concentrated into the area of tissue response to injury and includes: a) wound healing and related sciences, b) angiogenesis after injury and ischemia, c) shock resuscitation, transfusion medicine, and delivery of oxygen to tissues, d) traumatic brain injury and reperfusion, e) pulmonary responses to injury integrins, f) liver stress response, fibrosis and regeneration, g) leukocyte responses to injury including cytokines. The facilities include University of California San Francisco, Mt. Zion and San Francisco General Hospitals, a combined total of over 10,000 sq. ft of research space, the extensive equipment, and the consistently congenial and collaborative of the entire institution. In addition, facilities and expertise ion patient care are available in the SFGH Trauma Center and preventive activities. All mentor-eligible faculty members have major grant support.
| Kornblith, Lucy Z; Howard, Benjamin; Kunitake, Ryan et al. (2015) Obesity and clotting: Body mass index independently contributes to hypercoagulability after injury. J Trauma Acute Care Surg 78:30-6; discussion 37-8 |
| Kornblith, Lucy Z; Kutcher, Matthew E; Redick, Brittney J et al. (2014) Fibrinogen and platelet contributions to clot formation: implications for trauma resuscitation and thromboprophylaxis. J Trauma Acute Care Surg 76:255-6; discussion 262-3 |
| Kornblith, Lucy Z; Howard, Benjamin M; Cheung, Christopher K et al. (2014) The whole is greater than the sum of its parts: hemostatic profiles of whole blood variants. J Trauma Acute Care Surg 77:818-27 |
| Shue, Eveline H; Schecter, Samuel C; Gong, Wenhui et al. (2014) Antenatal maternally-administered phosphodiesterase type 5 inhibitors normalize eNOS expression in the fetal lamb model of congenital diaphragmatic hernia. J Pediatr Surg 49:39-45; discussion 45 |
| Kutcher, Matthew E; Kornblith, Lucy Z; Vilardi, Ryan F et al. (2014) The natural history and effect of resuscitation ratio on coagulation after trauma: a prospective cohort study. Ann Surg 260:1103-11 |
| Kornblith, Lucy Z; Kutcher, Matthew E; Callcut, Rachael A et al. (2013) Mechanical ventilation weaning and extubation after spinal cord injury: a Western Trauma Association multicenter study. J Trauma Acute Care Surg 75:1060-9; discussion 1069-70 |
| Kornblith, Lucy Z; Kutcher, Matthew E; Evans, Abigail E et al. (2013) The ""found down"" patient: a diagnostic dilemma. J Trauma Acute Care Surg 74:1548-52 |
| Shue, Eveline; Wu, Jianfeng; Schecter, Samuel et al. (2013) Aberrant pulmonary lymphatic development in the nitrofen mouse model of congenital diaphragmatic hernia. J Pediatr Surg 48:1198-204 |
| Kutcher, Matthew E; Ferguson, Adam R; Cohen, Mitchell J (2013) A principal component analysis of coagulation after trauma. J Trauma Acute Care Surg 74:1223-9; discussion 1229-30 |
| Kutcher, Matthew E; Kornblith, Lucy Z; Narayan, Raja et al. (2013) A paradigm shift in trauma resuscitation: evaluation of evolving massive transfusion practices. JAMA Surg 148:834-40 |
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