The central goal of our program is to train exceptional students for productive and creative careers in biomedical research. Over the years, we have observed that the best and most capable students are attracted towards programs that are interdisciplinary, flexible, and intellectually rich. These students are also keenly interested in programs that include faculty with diverse research interests, show evidence of extensive collaboration, and have strong institutional support. The training program molds a highly interactive group of students and faculty from many departments into a well organized unit who are dedicated to the mission of this program and the application of physical methodologies to solve significant biological and medically relevant problems. The goal of this training program is to exploit the resources available at the University of Pennsylvania to generate an integrated structural biology and molecular biophysics training program. Specifically the program is intended to provide students with a well-rounded didactic training in the biological and physical sciences. The training program will produce the next generation of scientists that are competent in both identifying the important biological problems of the 21st century and the ability to tackle these problems using the appropriate tools of molecular biophysics. Over the past 16 years, our training program in Structural Biology and Molecular Biophysics has provided an exceptional learning environment to our graduate student trainees. This proposal is put forward to allow the University of Pennsylvania to continue providing the highest quality training in Structural Biology and Molecular Biophysics. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008275-18
Application #
7089866
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Flicker, Paula F
Project Start
1988-09-30
Project End
2009-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
18
Fiscal Year
2006
Total Cost
$328,806
Indirect Cost
Name
University of Pennsylvania
Department
Biochemistry
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Sutherland, George A; Grayson, Katie J; Adams, Nathan B P et al. (2018) Probing the quality control mechanism of the Escherichia coli twin-arginine translocase with folding variants of a de novo-designed heme protein. J Biol Chem 293:6672-6681
O'Brien, Evan S; Lin, Danny W; Fuglestad, Brian et al. (2018) Improving yields of deuterated, methyl labeled protein by growing in H2O. J Biomol NMR 71:263-273
Vara, Brandon A; Li, Xingpin; Berritt, Simon et al. (2018) Scalable thioarylation of unprotected peptides and biomolecules under Ni/photoredox catalysis. Chem Sci 9:336-344
Caro, José A; Wand, A Joshua (2018) Practical aspects of high-pressure NMR spectroscopy and its applications in protein biophysics and structural biology. Methods 148:67-80
Bagchi, Atrish; Haidar, Jaafar N; Eastman, Scott W et al. (2018) Molecular Basis for Necitumumab Inhibition of EGFR Variants Associated with Acquired Cetuximab Resistance. Mol Cancer Ther 17:521-531
Yuan, Zuo-Fei; Sidoli, Simone; Marchione, Dylan M et al. (2018) EpiProfile 2.0: A Computational Platform for Processing Epi-Proteomics Mass Spectrometry Data. J Proteome Res 17:2533-2541
Guo, Lin; Kim, Hong Joo; Wang, Hejia et al. (2018) Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains. Cell 173:677-692.e20
Walters, Christopher R; Ferrie, John J; Petersson, E James (2018) Dithioamide substitutions in proteins: effects on thermostability, peptide binding, and fluorescence quenching in calmodulin. Chem Commun (Camb) 54:1766-1769
Armour, Sean M; Remsberg, Jarrett R; Damle, Manashree et al. (2017) An HDAC3-PROX1 corepressor module acts on HNF4? to control hepatic triglycerides. Nat Commun 8:549
Das, Arunika; Smoak, Evan M; Linares-Saldana, Ricardo et al. (2017) Centromere inheritance through the germline. Chromosoma 126:595-604

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