This proposal is a continuation of the training grant in Structural Biology of the Graduate Group in Biophysics at UCSF (GM08284). The program emphasizes interdisciplinary training at the interface of biology, physics and chemistry. A hallmark of the program is its use of structural experiment and computation to attack fundamental questions of intermolecular interactions, enzyme mechanisms and cell processes. The predoctoral students in the program rank among the best of any program at UCSF, and enter the program with backgrounds ranging from physics and chemistry to engineering, mathematics and biology. Their interests span a wide range of areas including structure-based drug design, the biochemical basis of disease, structural cell biology and macromolecular engineering. Training consists of a core curriculum, a minimum of three laboratory rotations, extensive practice in presenting journal clubs and research talks, an oral qualifying exam, and thesis research. Students completing this training are well prepared to bring their excellent skills and quantitative backgrounds to the solution of the most challenging problems in biomedical research. The proposal requests funding for thirteen positions.
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| Elting, Mary Williard; Suresh, Pooja; Dumont, Sophie (2018) The Spindle: Integrating Architecture and Mechanics across Scales. Trends Cell Biol 28:896-910 |
| Zhang, Yan; Burkhardt, David H; Rouskin, Silvi et al. (2018) A Stress Response that Monitors and Regulates mRNA Structure Is Central to Cold Shock Adaptation. Mol Cell 70:274-286.e7 |
| Calhoun, Sara; Korczynska, Magdalena; Wichelecki, Daniel J et al. (2018) Prediction of enzymatic pathways by integrative pathway mapping. Elife 7: |
| Morrissey, Meghan A; Williamson, Adam P; Steinbach, Adriana M et al. (2018) Chimeric antigen receptors that trigger phagocytosis. Elife 7: |
| Paquette, David R; Tibble, Ryan W; Daifuku, Tristan S et al. (2018) Control of mRNA decapping by autoinhibition. Nucleic Acids Res 46:6318-6329 |
| Leeman, Dena S; Hebestreit, Katja; Ruetz, Tyson et al. (2018) Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging. Science 359:1277-1283 |
| Heymann, J Bernard; Marabini, Roberto; Kazemi, Mohsen et al. (2018) The first single particle analysis Map Challenge: A summary of the assessments. J Struct Biol 204:291-300 |
| Palovcak, Eugene; Wang, Feng; Zheng, Shawn Q et al. (2018) A simple and robust procedure for preparing graphene-oxide cryo-EM grids. J Struct Biol 204:80-84 |
| Wall, Michael E; Wolff, Alexander M; Fraser, James S (2018) Bringing diffuse X-ray scattering into focus. Curr Opin Struct Biol 50:109-116 |
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