This proposal requests support for ten predoctoral trainees in the field of molecular biophysics, drawn principally from the interdepartmental Graduate Group in Biophysics, and the Departments of Chemistry and Molecular and Cell Biology. The 26 training faculty are drawn from the foregoing and from the Departments of Physics, Bioengineering, Chemical and Biomolecular Engineering, and Plant and Microbial Biology. Our faculty are world leaders in their fields and include five members of the National Academy of Sciences, five Howard Hughes Medical Institute Investigators, and a recent recipient of the Breakthrough Prize in Life Sciences. The Molecular Biophysics Training Grant is the only training program at UC Berkeley focussing on molecular biophysics and the only training grant that supports graduate training within the Graduate Group in Biophysics. The goal of the program is to train future leaders in the application of the most powerful physics-based technologies and concepts to the most intractable, medically, and societally important problems. We have a sustained track record of producing graduates who have become leaders in academia, industry, and government research laboratories. We accomplish this with an integrated program whose four pillars are 1) three laboratory rotations in the first year, followed by mentored research in the second year and beyond; 2) core coursework in biophysical modeling and physical biochemistry; 3) career development through monthly lunch meetings, networking with internal and external speakers, an annual retreat, and trainee conference attendance; 4) training in ethical conduct and scientific integrity, rigor, and reproducibility.
The Molecular Biophysics Training Grant supports a four-pronged approach to training future leaders in molecular biophysics through mentored research, core course work in biophysics and physical biochemistry, career development activities, and training in ethics and scientific integrity.
Shah, Neel H; Amacher, Jeanine F; Nocka, Laura M et al. (2018) The Src module: an ancient scaffold in the evolution of cytoplasmic tyrosine kinases. Crit Rev Biochem Mol Biol 53:535-563 |
Schöneberg, Johannes; Pavlin, Mark Remec; Yan, Shannon et al. (2018) ATP-dependent force generation and membrane scission by ESCRT-III and Vps4. Science 362:1423-1428 |
Amacher, Jeanine F; Hobbs, Helen T; Cantor, Aaron C et al. (2018) Phosphorylation control of the ubiquitin ligase Cbl is conserved in choanoflagellates. Protein Sci 27:923-932 |
Del Mármol, Josefina; Rietmeijer, Robert A; Brohawn, Stephen G (2018) Studying Mechanosensitivity of Two-Pore Domain K+ Channels in Cellular and Reconstituted Proteoliposome Membranes. Methods Mol Biol 1684:129-150 |
Harrington, Lucas B; Doxzen, Kevin W; Ma, Enbo et al. (2017) A Broad-Spectrum Inhibitor of CRISPR-Cas9. Cell 170:1224-1233.e15 |
Horitani, Masaki; Offenbacher, Adam R; Carr, Cody A Marcus et al. (2017) 13C ENDOR Spectroscopy of Lipoxygenase-Substrate Complexes Reveals the Structural Basis for C-H Activation by Tunneling. J Am Chem Soc 139:1984-1997 |
Nogales, Eva; Fang, Jie; Louder, Robert K (2017) Structural dynamics and DNA interaction of human TFIID. Transcription 8:55-60 |
Knott, Gavin J; East-Seletsky, Alexandra; Cofsky, Joshua C et al. (2017) Guide-bound structures of an RNA-targeting A-cleaving CRISPR-Cas13a enzyme. Nat Struct Mol Biol 24:825-833 |
Nogales, Eva; Louder, Robert K; He, Yuan (2017) Structural Insights into the Eukaryotic Transcription Initiation Machinery. Annu Rev Biophys 46:59-83 |
Sasmal, Sukanya; Lincoff, James; Head-Gordon, Teresa (2017) Effect of a Paramagnetic Spin Label on the Intrinsically Disordered Peptide Ensemble of Amyloid-?. Biophys J 113:1002-1011 |
Showing the most recent 10 out of 99 publications