The application of quantitative approaches to study biology and medicine is identified as an essential progression in future developments of biomedical research. The Molecular Biophysics Training Program (MBTP) at Vanderbilt specifically addresses this need by training students to work at the interface between quantitative molecular approaches and key problems in biology and medicine. Thus, the MBTP provides a deeper grounding in the physical sciences for trainees who have a biological sciences background and amore thorough exposure to the biological sciences and medicine than is usual for students with a physical sciences or engineering background. Though the program draws its training faculty from nine different departments, it is rooted in an established network of common research and training activities. In addition alto the 26 Training Faculty and 58 students, the training environment is greatly enriched by the active participation of ~40 scientific staff and postdoctoral fellows. Beyond a personally designed curriculum for each trainee, the MBTP holds two formal research seminar meetings each month involving the entire molecular biophysics community. The scope of research ranges from the design of small molecule drugs tothe structural analysis of multi-protein cellular machinery and from characterization of membrane proteins to following the movement of biomolecules into and out of cells. Research projects involve a broad spectrum of physical, chemical, and computational approaches, including X-ray crystallography, NMR, EPR and fluorescence spectroscopies, mass spectrometry, cryo-electron microscopy, cell imaging and molecular/cellular simulations, often involving multiple approaches. Trainees typically join the MBTP late in their first year of graduate training after choosing a thesis laboratory, and are then supported for two years. Grant support covers the time needed for additional specialized didactic training and the initiation of thesis research. However, all trainees (and their preceptors) remain active in MBTP program activities throughout the duration of their graduate training.

Public Health Relevance

The ultimate goal of Molecular Biophysics is to obtain a quantitative description of the shapes, surface features and network of interactions between the many thousands of molecules that bring a cell to life. Such knowledge provides a direct understanding of normal physiology and the malfunctions that lead to disease, and in turn can be used to develop drug therapies targeted specifically for the defective molecules.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008320-22
Application #
7880107
Study Section
Special Emphasis Panel (ZGM1-BRT-X (TG))
Program Officer
Flicker, Paula F
Project Start
1989-07-01
Project End
2014-06-30
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
22
Fiscal Year
2010
Total Cost
$306,141
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Biochemistry
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Sierra-Valdez, Francisco; Azumaya, Caleigh M; Romero, Luis O et al. (2018) Structure-function analyses of the ion channel TRPC3 reveal that its cytoplasmic domain allosterically modulates channel gating. J Biol Chem 293:16102-16114
Oviatt, Alexandria A; Kuriappan, Jissy A; Minniti, Elirosa et al. (2018) Polyamine-containing etoposide derivatives as poisons of human type II topoisomerases: Differential effects on topoisomerase II? and II?. Bioorg Med Chem Lett 28:2961-2968
Setliff, Ian; McDonnell, Wyatt J; Raju, Nagarajan et al. (2018) Multi-Donor Longitudinal Antibody Repertoire Sequencing Reveals the Existence of Public Antibody Clonotypes in HIV-1 Infection. Cell Host Microbe 23:845-854.e6
Koethe, John R; McDonnell, Wyatt; Kennedy, Arion et al. (2018) Adipose Tissue is Enriched for Activated and Late-Differentiated CD8+ T Cells and Shows Distinct CD8+ Receptor Usage, Compared With Blood in HIV-Infected Persons. J Acquir Immune Defic Syndr 77:e14-e21
Fenix, Aidan M; Neininger, Abigail C; Taneja, Nilay et al. (2018) Muscle-specific stress fibers give rise to sarcomeres in cardiomyocytes. Elife 7:
Starbird, C A; Tomasiak, Thomas M; Singh, Prashant K et al. (2018) New crystal forms of the integral membrane Escherichia coli quinol:fumarate reductase suggest that ligands control domain movement. J Struct Biol 202:100-104
Azumaya, Caleigh M; Sierra-Valdez, Francisco; Cordero-Morales, Julio F et al. (2018) Cryo-EM structure of the cytoplasmic domain of murine transient receptor potential cation channel subfamily C member 6 (TRPC6). J Biol Chem 293:10381-10391
Mittendorf, Kathleen F; Marinko, Justin T; Hampton, Cheri M et al. (2017) Peripheral myelin protein 22 alters membrane architecture. Sci Adv 3:e1700220
O'Brien, Elizabeth; Holt, Marilyn E; Thompson, Matthew K et al. (2017) The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport. Science 355:
Lehtimäki, Jaakko I; Fenix, Aidan M; Kotila, Tommi M et al. (2017) UNC-45a promotes myosin folding and stress fiber assembly. J Cell Biol 216:4053-4072

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