Abstract

Funds are requested to support the training of six predoctoral students during their first two years of participation in the Duke University Program in Molecular Biophysics (MBP). The Program consists of 25 faculty from 10 departments, including Biochemistry, Biomedical Engineering, Cell Biology, Electrical and Computer Engineering, Mechanical Engineering and Materials Science, Neurobiology and Pharmacology. The MBP is designed to prepare students with a variety of undergraduate backgrounds to apply quantitative physical methods to the study of biological processes. The program plays a pivotal role in recruiting students with diverse backgrounds including physics, math, chemistry and biology to work in the consortium of Biological Sciences departments and programs at Duke. The primary goal of the program is to provide trainees with a stimulating interdisciplinary environment in which to learn the tools of modern structural biology and biophysics and to support their individual research efforts as they apply these tools to important biological problems. Through this training experience, students are prepared for a variety of research settings in academia and industry.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008487-09
Application #
6498461
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Flicker, Paula F
Project Start
1994-07-01
Project End
2004-06-30
Budget Start
2002-07-01
Budget End
2003-06-30
Support Year
9
Fiscal Year
2002
Total Cost
$217,431
Indirect Cost

  Institution

Name
Duke University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705

  Publications

Ganser, Laura R; Lee, Janghyun; Rangadurai, Atul et al. (2018) High-performance virtual screening by targeting a high-resolution RNA dynamic ensemble. Nat Struct Mol Biol 25:425-434
Burg, Jonathan M; Gonzalez, Julie J; Maksimchuk, Kenneth R et al. (2016) Lysine-Specific Demethylase 1A (KDM1A/LSD1): Product Recognition and Kinetic Analysis of Full-Length Histones. Biochemistry 55:1652-62
Merriman, Dawn K; Xue, Yi; Yang, Shan et al. (2016) Shortening the HIV-1 TAR RNA Bulge by a Single Nucleotide Preserves Motional Modes over a Broad Range of Time Scales. Biochemistry 55:4445-56
Bellucci, Joseph J; Bhattacharyya, Jayanta; Chilkoti, Ashutosh (2015) A noncanonical function of sortase enables site-specific conjugation of small molecules to lysine residues in proteins. Angew Chem Int Ed Engl 54:441-5
Mosley, Pamela L; Daniels, Kyle G; Oas, Terrence G (2015) Electrostatic Energetics of Bacillus subtilis Ribonuclease P Protein Determined by Nuclear Magnetic Resonance-Based Histidine pKa Measurements. Biochemistry 54:5379-88
Burg, Jonathan M; Link, Jennifer E; Morgan, Brittany S et al. (2015) KDM1 class flavin-dependent protein lysine demethylases. Biopolymers 104:213-46
Burg, Jonathan M; Makhoul, Alan T; Pemble 4th, Charles W et al. (2015) A rationally-designed chimeric KDM1A/KDM1B histone demethylase tower domain deletion mutant retaining enzymatic activity. FEBS Lett 589:2340-6
Scholl, Zackary N; Marszalek, Piotr E (2014) Improving single molecule force spectroscopy through automated real-time data collection and quantification of experimental conditions. Ultramicroscopy 136:7-14
Kovach, Alexander R; Hoff, Kirsten E; Canty, John T et al. (2014) Recognition of U-rich RNA by Hfq from the Gram-positive pathogen Listeria monocytogenes. RNA 20:1548-59
Hardy, Gregory J; Nayak, Rahul; Zauscher, Stefan (2013) Model cell membranes: Techniques to form complex biomimetic supported lipid bilayers via vesicle fusion. Curr Opin Colloid Interface Sci 18:448-458

Showing the most recent 10 out of 26 publications