Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008492-10
Application #
6498463
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Flicker, Paula F
Project Start
1993-07-01
Project End
2003-06-30
Budget Start
2002-07-01
Budget End
2003-06-30
Support Year
10
Fiscal Year
2002
Total Cost
$102,845
Indirect Cost
Name
Washington University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Maynard, Caroline M; Hall, Kathleen B (2010) Interactions between PTB RRMs induce slow motions and increase RNA binding affinity. J Mol Biol 397:260-77
Bradley, Michael J; Chivers, Peter T; Baker, Nathan A (2008) Molecular dynamics simulation of the Escherichia coli NikR protein: equilibrium conformational fluctuations reveal interdomain allosteric communication pathways. J Mol Biol 378:1155-73
Niedziela-Majka, Anita; Chesnik, Marla A; Tomko, Eric J et al. (2007) Bacillus stearothermophilus PcrA monomer is a single-stranded DNA translocase but not a processive helicase in vitro. J Biol Chem 282:27076-85
Nybakken, Grant E; Nelson, Christopher A; Chen, Beverly R et al. (2006) Crystal structure of the West Nile virus envelope glycoprotein. J Virol 80:11467-74
Bruck, Serawit; Huber, Tobias B; Ingham, Robert J et al. (2006) Identification of a novel inhibitory actin-capping protein binding motif in CD2-associated protein. J Biol Chem 281:19196-203
Wong, C Jason; Lucius, Aaron L; Lohman, Timothy M (2005) Energetics of DNA end binding by E.coli RecBC and RecBCD helicases indicate loop formation in the 3'-single-stranded DNA tail. J Mol Biol 352:765-82
Fischer, Christopher J; Maluf, Nasib K; Lohman, Timothy M (2004) Mechanism of ATP-dependent translocation of E.coli UvrD monomers along single-stranded DNA. J Mol Biol 344:1287-309
Lucius, Aaron L; Lohman, Timothy M (2004) Effects of temperature and ATP on the kinetic mechanism and kinetic step-size for E.coli RecBCD helicase-catalyzed DNA unwinding. J Mol Biol 339:751-71
Maluf, Nasib K; Lohman, Timothy M (2003) Self-association equilibria of Escherichia coli UvrD helicase studied by analytical ultracentrifugation. J Mol Biol 325:889-912
Maluf, Nasib K; Fischer, Christopher J; Lohman, Timothy M (2003) A Dimer of Escherichia coli UvrD is the active form of the helicase in vitro. J Mol Biol 325:913-35

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