The overall objective of the Chemistry-Biology Interface Predoctoral Training Program (CBIT) at the University of Wisconsin-Madison is to facilitate interdisciplinary research in which chemical and biological approaches are applied to illuminate and manipulate biological processes. To achieve these ends, the program provides multidisciplinary research opportunities and interactions, forums to develop trainee communication skills, and mechanisms for exploring scientific creativity and critical thinking. The CBIT offers interdisciplinary research opportunities in 45 research groups. There are 5 major participating graduate programs from which most CBI trainees earn their degrees: the Integrated Program in Biochemistry, the Department of Chemical and Biological Engineering, the Division of Pharmaceutical Sciences, the Microbiology Doctoral Training Program, and the Department of Chemistry. In the past grant period,14-18 outstanding predoctoral trainees have participated in the CBI-TP (approximately 2/3 is supported by the program and 1/3 by other fellowships). These trainees are recruited from a national pool of students and trainers engage in a variety of approaches to attract trainees from groups that are underrepresented in the biomedical sciences. The research being pursued in these venues is directly relevant to addressing the major challenges facing human health. Trainees take courses that use innovative teaching methods to show them how to merge chemical and biological concepts to explore biological systems (Chemical Biology), discuss recent key publications in chemical biology (Chemical Biology Advanced Seminar), get a grounding in scientific research ethics (Ethics), participate in discussions focused on developing academic and professional skills, complete a 10-12 week industrial internship, and present their research to peers (Highlights at the Chemistry-Biology Interface). Since the CBI-TP was initiated in 1993, UW-Madison has built an extensive infrastructure for conducting chemical biology research. This infrastructure, when combined with the interactive and collaborative atmosphere on campus and an emphasis on graduate training, affords an environment uniquely conducive to interdisciplinary training in chemical biology.
The relevance of the Chemical-Biology Interface Predoctoral Training Program to public health is significant. The course selection and associated programmatic features ensure that the prospective trainees have an appropriate means to obtain quantitative backgrounds and exposure to topics directly related to human health, physiology, and disease mechanisms.
| Kang, Lei; Jiang, Dawei; Ehlerding, Emily B et al. (2018) Noninvasive Trafficking of Brentuximab Vedotin and PET Imaging of CD30 in Lung Cancer Murine Models. Mol Pharm 15:1627-1634 |
| Ehlerding, Emily B; Lacognata, Saige; Jiang, Dawei et al. (2018) Targeting angiogenesis for radioimmunotherapy with a 177Lu-labeled antibody. Eur J Nucl Med Mol Imaging 45:123-131 |
| Zhan, Yonghua; Ehlerding, Emily B; Shi, Sixiang et al. (2018) Intrinsically Zirconium-89-Labeled Manganese Oxide Nanoparticles for In Vivo Dual-Modality Positron Emission Tomography and Magnetic Resonance Imaging. J Biomed Nanotechnol 14:900-909 |
| Ehlerding, Emily B; Grodzinski, Piotr; Cai, Weibo et al. (2018) Big Potential from Small Agents: Nanoparticles for Imaging-Based Companion Diagnostics. ACS Nano 12:2106-2121 |
| Ehlerding, Emily B; Ferreira, Carolina A; Aluicio-Sarduy, Eduardo et al. (2018) 86/90Y-Based Theranostics Targeting Angiogenesis in a Murine Breast Cancer Model. Mol Pharm 15:2606-2613 |
| Reidenbach, Andrew G; Kemmerer, Zachary A; Aydin, Deniz et al. (2018) Conserved Lipid and Small-Molecule Modulation of COQ8 Reveals Regulation of the Ancient Kinase-like UbiB Family. Cell Chem Biol 25:154-165.e11 |
| Lee, Hye Jin; Ehlerding, Emily B; Cai, Weibo (2018) Antibody-Based Tracers for PET/SPECT Imaging of Chronic Inflammatory Diseases. Chembiochem : |
| Wei, Weijun; Ni, Dalong; Ehlerding, Emily B et al. (2018) PET Imaging of Receptor Tyrosine Kinases in Cancer. Mol Cancer Ther 17:1625-1636 |
| Ni, Dalong; Ehlerding, Emily B; Cai, Weibo (2018) Multimodality Imaging Agents with PET as the Fundamental Pillar. Angew Chem Int Ed Engl : |
| Ellison, Aubrey J; Raines, Ronald T (2018) A pendant peptide endows a sunscreen with water-resistance. Org Biomol Chem 16:7139-7142 |
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