EXCEED THE SPACE PROVIDED. Continuing funding is requested to support 9 predoctoral trainees of the Chemistry/Biology Training Program, for the next five-years. The Training Program consists of 27 faculty members from four participating graduate units: Organic Division of the Chemistry Department, Biological Division of the Chemistry Department, Division of Medicinal Chemistry of the College of Pharmacy, and the Ohio State Biochemistry Program (OSBP). The participating faculty members from OSBP are affiliated with many departments and colleges. The research projects of the participating faculty cover five broad areas: Area 1: Organic, Bioorganic and Medicinal Chemistry; Area 2: Structure- Function Relationship of Macromolecules; Area 3: Membranes and Membrane Proteins; Area 4: Gene Regulation and Expression; and Area 5: Biochemical Basis of Disease. The Chemistry/Biology Training Program is not a separate graduate program. Instead, students will be recruited into the four participating graduate programs and receive training at the chemistry/biology interface. Key elements of the training include monthly luncheon seminars, annual symposium, regular seminars, and the requirement to cover both chemistry and biology disciplines in lab rotations, course work, general exam proposals, and dissertation research. The Executive Committee will evaluate the progress of trainees annually for reappointment. Trainees will attend a workshop on Responsible Conduct of Research. Strong effort will be devoted to recruiting and retention of underrepresented minority students. During the past four years, 18 trainees have participated in the program; many of the trainees have also been supported by other fellowships from the university. PERFORMANCE SITE ========================================Section End===========================================
| Rhodes, Curran A; Dougherty, Patrick G; Cooper, Jahan K et al. (2018) Cell-Permeable Bicyclic Peptidyl Inhibitors against NEMO-I?B Kinase Interaction Directly from a Combinatorial Library. J Am Chem Soc 140:12102-12110 |
| Bacusmo, Jo Marie; Kuzmishin, Alexandra B; Cantara, William A et al. (2018) Quality control by trans-editing factor prevents global mistranslation of non-protein amino acid ?-aminobutyrate. RNA Biol 15:576-585 |
| Schneider, Camille R; Manesis, Anastasia C; Stevenson, Michael J et al. (2018) A photoactive semisynthetic metalloenzyme exhibits complete selectivity for CO2 reduction in water. Chem Commun (Camb) 54:4681-4684 |
| Olson, Erik D; Musier-Forsyth, Karin (2018) Retroviral Gag protein-RNA interactions: Implications for specific genomic RNA packaging and virion assembly. Semin Cell Dev Biol : |
| Wilson, Tyler A; Tokarski 2nd, Robert J; Sullivan, Peter et al. (2018) Total Synthesis of Scytonemide A Employing Weinreb AM Solid-Phase Resin. J Nat Prod 81:534-542 |
| Raper, Austin T; Stephenson, Anthony A; Suo, Zucai (2018) Functional Insights Revealed by the Kinetic Mechanism of CRISPR/Cas9. J Am Chem Soc 140:2971-2984 |
| Stephenson, Anthony A; Raper, Austin T; Suo, Zucai (2018) Bidirectional Degradation of DNA Cleavage Products Catalyzed by CRISPR/Cas9. J Am Chem Soc 140:3743-3750 |
| Danhart, Eric M; Bakhtina, Marina; Cantara, William A et al. (2017) Conformational and chemical selection by a trans-acting editing domain. Proc Natl Acad Sci U S A 114:E6774-E6783 |
| Qian, Ziqing; Rhodes, Curran A; McCroskey, Lucas C et al. (2017) Enhancing the Cell Permeability and Metabolic Stability of Peptidyl Drugs by Reversible Bicyclization. Angew Chem Int Ed Engl 56:1525-1529 |
| Comandur, Roopa; Olson, Erik D; Musier-Forsyth, Karin (2017) Conservation of tRNA mimicry in the 5'-untranslated region of distinct HIV-1 subtypes. RNA 23:1850-1859 |
Showing the most recent 10 out of 98 publications
