The Mount Sinai School of Medicine (MSSM) proposes to continue and expand a highly successful training program in Cellular and Molecular Biology (CMB) for predoctoral fellows. This program reflects an expansion of CMB relevant research at MSSM, which has experienced a large growth in NIH funding over the past 8 years. The training program reflects an integral component of the institution's Graduate Program, in which training mentors play key leadership roles. The program encompasses a laboratory-based, multidisciplinary predoctoral training in cellular and molecular biology. To current grant supports four predoctoral trainees. The program has demonstrated the ability to attract and develop a cadre of outstanding PhD and MD/PhD students in CMB focused research and attracts an increasing number of students to the laboratories of the CMB training faculty to conduct their predoctoral thesis research. The added component would include 2 predoctoral fellows to be added at the second and third year of the funding period. The training faculty consists of 52 preceptors from 15 departments throughout Mount Sinai. Of these faculty members, all have peer-reviewed support from NIH and other extramural agencies. The curriculum for the predoctoral trainees involves some core elements including advanced course work in cellular and molecular biology, as well as genetics and genomics and related structural studies. There will also be a specific training element and exposure to Stem Cell research and other medically highly relevant research areas. The training program includes a rigorous evaluation and selection process for trainees, and the program is both cognizant of and actively involved in minority recruitment. The CMB training program combines cutting edge research with a high standard academic curriculum, and many interfaces with the clinical side to highlight the relevance of the basic research training to medical applications. The trainees will work closely with faculty drawn from throughout Mount Sinai and ensuring that the trainees'research is both comprehensive in scope and broad to cover all relevant areas of the CMB training program.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008553-15
Application #
7646268
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Zatz, Marion M
Project Start
1995-07-01
Project End
2010-06-30
Budget Start
2009-07-01
Budget End
2010-06-30
Support Year
15
Fiscal Year
2009
Total Cost
$78,723
Indirect Cost
Name
Icahn School of Medicine at Mount Sinai
Department
Biology
Type
Schools of Medicine
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
Li, Ronald A; Keung, Wendy; Cashman, Timothy J et al. (2018) Bioengineering an electro-mechanically functional miniature ventricular heart chamber from human pluripotent stem cells. Biomaterials 163:116-127
Lam, Larry; Chin, Lydia; Halder, Ramesh C et al. (2016) Epigenetic changes in T-cell and monocyte signatures and production of neurotoxic cytokines in ALS patients. FASEB J 30:3461-3473
Cashman, Timothy J; Josowitz, Rebecca; Gelb, Bruce D et al. (2016) Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy. J Vis Exp :e53447
Cashman, Timothy J; Josowitz, Rebecca; Johnson, Bryce V et al. (2016) Human Engineered Cardiac Tissues Created Using Induced Pluripotent Stem Cells Reveal Functional Characteristics of BRAF-Mediated Hypertrophic Cardiomyopathy. PLoS One 11:e0146697
Rimmelé, Pauline; Liang, Raymond; Bigarella, Carolina L et al. (2015) Mitochondrial metabolism in hematopoietic stem cells requires functional FOXO3. EMBO Rep 16:1164-76
Liang, Raymond; Campreciós, Genís; Kou, Yan et al. (2015) A Systems Approach Identifies Essential FOXO3 Functions at Key Steps of Terminal Erythropoiesis. PLoS Genet 11:e1005526
Tsai, Su-Yi; Sennett, Rachel; Rezza, Amélie et al. (2014) Wnt/?-catenin signaling in dermal condensates is required for hair follicle formation. Dev Biol 385:179-88
Rezza, Amélie; Sennett, Rachel; Rendl, Michael (2014) Adult stem cell niches: cellular and molecular components. Curr Top Dev Biol 107:333-72
Sennett, Rachel; Rezza, Amélie; Dauber, Katherine L et al. (2014) Cxcr4 is transiently expressed in both epithelial and mesenchymal compartments of nascent hair follicles but is not required for follicle formation. Exp Dermatol 23:748-50
Rimmelé, Pauline; Bigarella, Carolina L; Liang, Raymond et al. (2014) Aging-like phenotype and defective lineage specification in SIRT1-deleted hematopoietic stem and progenitor cells. Stem Cell Reports 3:44-59

Showing the most recent 10 out of 27 publications