The primary purpose of this broadly based multidisciplinary Training Program is to prepare students for biomedical research careers in schools of medicine, dentistry and pharmacy, in research institutes, and in governmental or industrial laboratories. A major goal is to provide trainees with a program in which they will be exposed to several areas of biomedical research relevant to modern pharmacology. The areas of research emphasis represented by the 40 training faculty include transmembrane signaling, cell growth control and molecular recognition, substance abuse, and molecular toxicology. Training faculty represent 13 departments and two Centers at Emory. The most important component of training is laboratory research, first as a series of three research rotations, then in the dissertation laboratory. This training is complemented by core courses in pharmacology that emphasize quantitative analysis of drug action, including receptor structure and function, courses in biochemistry/molecular biology and biostatistics, and advanced courses in specialty areas; by seminar courses and by journal clubs. Emphasis throughout is placed on oral presentation skills; students make formal oral presentations of their own work or that in the literature on numerous occasions before their dissertation defense. The Program is designed to support two students the first year, increasing to six per year by year 3. The student who completes the predoctoral training program will have acquired broad familiarity with pharmacology, knowledge in depth in the area of dissertation research, the ability to search, read critically and report on the literature of the biomedical sciences, mastery of a variety of laboratory techniques useful in modem biomedical research, skill in planning and executing a research project, ability to write clear, accurate scientific reports for publication, and ability to present effectively the results of research. A large percentage of the previous trainees of the core faculty have obtained postdoctoral training and then secured desirable positions in academic or industrial institutions; they continue to be productive in biomedical sciences.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008602-05
Application #
6150925
Study Section
Pharmacology-Toxicology Review Committee (PTR)
Program Officer
Preusch, Peter C
Project Start
1996-07-01
Project End
2001-06-30
Budget Start
2000-07-01
Budget End
2001-06-30
Support Year
5
Fiscal Year
2000
Total Cost
$97,199
Indirect Cost
Name
Emory University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Salam, Akram M; Quave, Cassandra L (2018) Targeting Virulence in Staphylococcus aureus by Chemical Inhibition of the Accessory Gene Regulator System In Vivo. mSphere 3:
Squires, Katherine E; MontaƱez-Miranda, Carolina; Pandya, Rushika R et al. (2018) Genetic Analysis of Rare Human Variants of Regulators of G Protein Signaling Proteins and Their Role in Human Physiology and Disease. Pharmacol Rev 70:446-474
Fernandes, Jolyn; Chandler, Joshua D; Liu, Ken H et al. (2018) Putrescine as indicator of manganese neurotoxicity: Dose-response study in human SH-SY5Y cells. Food Chem Toxicol 116:272-280
Wells, Gordon; Yuan, Hongjie; McDaniel, Miranda J et al. (2018) The GluN2B-Glu413Gly NMDA receptor variant arising from a de novo GRIN2B mutation promotes ligand-unbinding and domain opening. Proteins 86:1265-1276
Bian, Xuehai; Liang, Zhongxing; Feng, Amber et al. (2018) HDAC inhibitor suppresses proliferation and invasion of breast cancer cells through regulation of miR-200c targeting CRKL. Biochem Pharmacol 147:30-37
Hudson, William H; Vera, Ian Mitchelle S de; Nwachukwu, Jerome C et al. (2018) Cryptic glucocorticoid receptor-binding sites pervade genomic NF-?B response elements. Nat Commun 9:1337
Brown, Harrison C; Zakas, Philip M; George, Stephan N et al. (2018) Target-Cell-Directed Bioengineering Approaches for Gene Therapy of Hemophilia A. Mol Ther Methods Clin Dev 9:57-69
Gibb, Alasdair J; Ogden, Kevin K; McDaniel, Miranda J et al. (2018) A structurally derived model of subunit-dependent NMDA receptor function. J Physiol 596:4057-4089
Collins, Jeffrey M; Walker, Douglas I; Jones, Dean P et al. (2018) High-resolution plasma metabolomics analysis to detect Mycobacterium tuberculosis-associated metabolites that distinguish active pulmonary tuberculosis in humans. PLoS One 13:e0205398
Hansen, Kasper B; Yi, Feng; Perszyk, Riley E et al. (2018) Structure, function, and allosteric modulation of NMDA receptors. J Gen Physiol 150:1081-1105

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