The MCD Biology training program will provide intensive training in the skills necessary for outstanding research in modern, molecular, cellular, and developmental biology. The structure of the training program has been established and refined during the past 10 years. Incoming graduate undertake intensive coursework aimed at providing a solid framework upon which to build during their graduate careers, emphasizing critical evaluation of scientific models, experimental approaches, and results. First-year trainees participate in a laboratory rotation program in which they carry out ten-week research projects in three different laboratories, thereby gaining exposure to a number of different experimental systems. Second year students are required to pass an oral qualifying exam, and advanced students participate in a variety of seminars, advanced special topics courses, and research group meetings designs to provide continuing learning opportunities. The goal of the training program is to produce outstanding graduates who have a strong foundation in the specific area of their thesis research, and who are broadly trained in molecular, cellular, and developmental biology. The hallmarks of our program are an outstanding, young, and highly interactive faculty, close faculty-student interaction, and high-quality graduate training. Research in the MCD Biology program is organized in clusters of faculty with shared interests, thereby creating critical masses of researchers to foster mutual support and scientific interaction. One such cluster, encompassed by the Markey Center for the Molecular Biology of RNA, is internationally recognized for the study of RNA. The foci of the other research cluster include developmental biology, cell biology, structural biology, and plant molecular biology. Students in the MCD Biology training program are therefore exposed to a wide range of different experimental problems and systems. We are requesting support for a total of 6 predoctoral student positions during the first year of the program which will be awarded to recruit outstanding students and to encourage excellence in the performance of our best students. Administration of the training program will be under the direction of an Executive Committee and the Program Director.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008646-04
Application #
6498495
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Zatz, Marion M
Project Start
1999-07-01
Project End
2004-06-30
Budget Start
2002-07-01
Budget End
2003-06-30
Support Year
4
Fiscal Year
2002
Total Cost
$116,034
Indirect Cost
Name
University of California Santa Cruz
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
City
Santa Cruz
State
CA
Country
United States
Zip Code
95064
Elling, Roland; Robinson, Elektra K; Shapleigh, Barbara et al. (2018) Genetic Models Reveal cis and trans Immune-Regulatory Activities for lincRNA-Cox2. Cell Rep 25:1511-1524.e6
Bohr, Tisha; Nelson, Christian R; Giacopazzi, Stefani et al. (2018) Shugoshin Is Essential for Meiotic Prophase Checkpoints in C. elegans. Curr Biol 28:3199-3211.e3
Bogdanoff, Walter A; Perez, Edmundo I; López, Tomás et al. (2018) Structural Basis for Escape of Human Astrovirus from Antibody Neutralization: Broad Implications for Rational Vaccine Design. J Virol 92:
MacRae, Andrew J; Mayerle, Megan; Hrabeta-Robinson, Eva et al. (2018) Prp8 positioning of U5 snRNA is linked to 5' splice site recognition. RNA 24:769-777
Howard, Jonathan M; Lin, Hai; Wallace, Andrew J et al. (2018) HNRNPA1 promotes recognition of splice site decoys by U2AF2 in vivo. Genome Res 28:689-698
Cuoco, Joshua A; Esposito, Anthony W; Moriarty, Shannon et al. (2018) Malformation of the Posterior Cerebellar Vermis Is a Common Neuroanatomical Phenotype of Genetically Engineered Mice on the C57BL/6 Background. Cerebellum 17:173-190
Warecki, Brandt; Sullivan, William (2018) Micronuclei Formation Is Prevented by Aurora B-Mediated Exclusion of HP1a from Late-Segregating Chromatin in Drosophila. Genetics 210:171-187
Schwiesow, Leah; Mettert, Erin; Wei, Yahan et al. (2018) Control of hmu Heme Uptake Genes in Yersinia pseudotuberculosis in Response to Iron Sources. Front Cell Infect Microbiol 8:47
Kessenbrock, Kai; Smith, Prestina; Steenbeek, Sander Christiaan et al. (2017) Diverse regulation of mammary epithelial growth and branching morphogenesis through noncanonical Wnt signaling. Proc Natl Acad Sci U S A 114:3121-3126
Peterson, Misty R; Hamdani, Omar; Kamakaka, Rohinton T (2017) Methods to Study the Atypical Roles of DNA Repair and SMC Proteins in Gene Silencing. Methods Mol Biol 1515:151-176

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