This renewal proposal seeks continuing support for the NIH/CU Molecular Biophysics Training Program at the University of Colorado, Boulder. The goal of this 4-year old program is to prepare exceptional, highly motivated biophysics students for productive research careers. The 30 training faculty are an outstanding, internationally recognized group of investigators centered in three departments: Chemistry & Biochemistry; Molecular, Cellular & Developmental Biology; and Chemical & Biological Engineering. These faculties, together with their students, are using state-of-the-art biophysical methods to elucidate fundamental aspects of macromolecular structure, dynamics, mechanism, and function in systems ranging from single molecules to complex, multi-component assemblies. Molecular Biophysics is the most rapidly growing research field on the Boulder campus, where 12 new biophysical faculties have arrived in the past 5 years. An important driving force behind this growth is the NIH/CU Molecular Biophysics Training Program, which establishes a strong sense of community and inters- connectedness among biophysicists in different laboratories and departments. Moreover, the program maintains a rigorous training environment for predoctoral students of biophysics. The training program, which is supported both by NIH and by CU matching funds, ensures that predoctoral students receive the broad, interdisciplinary foundation needed to carry out cutting edge biophysical research. Training includes specialized coursework, laboratory rotations, and teaching duties during the first year. Training continues with additional coursework in the second year. Required courses include scientific ethics as well as biophysical courses developed by the program. Following the second year, students meet yearly with a faculty committee that provides independent mentoring for their thesis research. In all training years, regular Biophysics Seminars and Super group meetings maintain strong communication between biophysical students and faculty. During its first four years of NIH support the training program has flourished in multiple dimensions while benefiting from: 1) exciting new faculty, 2) growing student participation, 3) increasing quality of the selected trainees, 4) new courses, and 5) growing recruitment of minority and female students. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
2T32GM065103-06
Application #
7232571
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Flicker, Paula F
Project Start
2002-07-01
Project End
2012-06-30
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
6
Fiscal Year
2007
Total Cost
$191,825
Indirect Cost
Name
University of Colorado at Boulder
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
007431505
City
Boulder
State
CO
Country
United States
Zip Code
80309
Nicholson, David A; Sengupta, Abhigyan; Sung, Hsuan-Lei et al. (2018) Amino Acid Stabilization of Nucleic Acid Secondary Structure: Kinetic Insights from Single-Molecule Studies. J Phys Chem B 122:9869-9876
Protter, David S W; Rao, Bhalchandra S; Van Treeck, Briana et al. (2018) Intrinsically Disordered Regions Can Contribute Promiscuous Interactions to RNP Granule Assembly. Cell Rep 22:1401-1412
Hjortness, Michael K; Riccardi, Laura; Hongdusit, Akarawin et al. (2018) Abietane-Type Diterpenoids Inhibit Protein Tyrosine Phosphatases by Stabilizing an Inactive Enzyme Conformation. Biochemistry 57:5886-5896
Lloyd, Neil R; Wuttke, Deborah S (2018) Discrimination against RNA Backbones by a ssDNA Binding Protein. Structure 26:722-733.e2
Heenan, Patrick R; Yu, Hao; Siewny, Matthew G W et al. (2018) Improved free-energy landscape reconstruction of bacteriorhodopsin highlights local variations in unfolding energy. J Chem Phys 148:123313
Brown, Tobin E; Carberry, Benjamin J; Worrell, Brady T et al. (2018) Photopolymerized dynamic hydrogels with tunable viscoelastic properties through thioester exchange. Biomaterials 178:496-503
Van Patten, William J; Walder, Robert; Adhikari, Ayush et al. (2018) Improved Free-Energy Landscape Quantification Illustrated with a Computationally Designed Protein-Ligand Interaction. Chemphyschem 19:19-23
Braselmann, Esther; Wierzba, Aleksandra J; Polaski, Jacob T et al. (2018) A multicolor riboswitch-based platform for imaging of RNA in live mammalian cells. Nat Chem Biol 14:964-971
Lewis, Katherine J R; Hall, Jessica K; Kiyotake, Emi A et al. (2018) Epithelial-mesenchymal crosstalk influences cellular behavior in a 3D alveolus-fibroblast model system. Biomaterials 155:124-134
Polaski, Jacob T; Kletzien, Otto A; Drogalis, Lea K et al. (2018) A functional genetic screen reveals sequence preferences within a key tertiary interaction in cobalamin riboswitches required for ligand selectivity. Nucleic Acids Res 46:9094-9105

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