This application requests funds to support the training of predoctoral students in the Program in Molecular and Cellular Biosciences (PMCB) at Oregon Health & Science University. This interdisciplinary program brings together 175 faculty members from five basic science departments (Biochemistry and Molecular Biology, Cell and Developmental Biology, Molecular and Medical Genetics, Molecular Microbiology and Immunology, and Physiology and Pharmacology) and affiliated research institutes to provide first- and second-year graduate students with the theoretical and laboratory foundation they require to become successful research scientists. This proposal will support six Ph.D. students out of the 119 currently enrolled in the PMCB for their first two years of training. The 80-member training faculty members in this application are internationally recognized for their expertise in biophysical, molecular, cellular, and developmental approaches to important and compelling biological questions using state-of-the art methodologies. Notably, graduate students also directly participate in ground-breaking translational research, ranging from the development of the first small molecule inhibitor of cancer (Gleevec) to the first liver stem cell therapy, the molecular basis of obesity, and the development of new vaccines for emerging pathogens. Our program offers qualified students a common, rigorous didactic grounding for the first year, and continued grounding as students begin to specialize during their second year. Students also participate in seminar series, program retreats, teaching, and may attend scientific meetings. Students must successfully pass a comprehensive written exam at the end of their first year and a qualifying exam at the end of their second year, in which they prepare and defend an original research proposal. Subsequently, students are formally admitted to one of the five participating departments to conduct a research project leading to the awarding of a Doctorate of Philosophy. Importantly, the dynamic research community at OHSU, combined with the proximity of basic and clinical research facilities, provide a unique opportunity for Ph.D. students to form cross-discipline collaborations during their training and to gain an appreciation of the health-relatedness of the basic science research that they undertake. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM071338-02
Application #
7084503
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Zatz, Marion M
Project Start
2005-07-01
Project End
2010-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
2
Fiscal Year
2006
Total Cost
$166,507
Indirect Cost
Name
Oregon Health and Science University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Hobbs, Samuel J; Osborn, Jossef F; Nolz, Jeffrey C (2018) Activation and trafficking of CD8+ T cells during viral skin infection: immunological lessons learned from vaccinia virus. Curr Opin Virol 28:12-19
Van Winkle, Jacob A; Robinson, Bridget A; Peters, A Mack et al. (2018) Persistence of Systemic Murine Norovirus Is Maintained by Inflammatory Recruitment of Susceptible Myeloid Cells. Cell Host Microbe 24:665-676.e4
Risom, Tyler; Langer, Ellen M; Chapman, Margaret P et al. (2018) Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer. Nat Commun 9:3815
Wu, Yi; Fortin, Dale A; Cochrane, Veronica A et al. (2017) NMDA receptors mediate leptin signaling and regulate potassium channel trafficking in pancreatic ?-cells. J Biol Chem 292:15512-15524
Watanabe-Smith, Kevin; Godil, Jamila; Agarwal, Anupriya et al. (2017) Analysis of acquired mutations in transgenes arising in Ba/F3 transformation assays: findings and recommendations. Oncotarget 8:12596-12606
Hobbs, Samuel J; Nolz, Jeffrey C (2017) Regulation of T Cell Trafficking by Enzymatic Synthesis of O-Glycans. Front Immunol 8:600
Earley, Lauriel F; Powers, John M; Adachi, Kei et al. (2017) Adeno-associated Virus (AAV) Assembly-Activating Protein Is Not an Essential Requirement for Capsid Assembly of AAV Serotypes 4, 5, and 11. J Virol 91:
Watanabe-Smith, K; Tognon, C; Tyner, J W et al. (2016) Discovery and functional characterization of a germline, CSF2RB-activating mutation in leukemia. Leukemia 30:1950-3
Schafer, Christopher T; Fay, Jonathan F; Janz, Jay M et al. (2016) Decay of an active GPCR: Conformational dynamics govern agonist rebinding and persistence of an active, yet empty, receptor state. Proc Natl Acad Sci U S A 113:11961-11966
Lazelle, Rebecca A; McCully, Belinda H; Terker, Andrew S et al. (2016) Renal Deletion of 12 kDa FK506-Binding Protein Attenuates Tacrolimus-Induced Hypertension. J Am Soc Nephrol 27:1456-64

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