The primary goal of this training program is to provide multidisciplinary predoctoral and postdoctoral training in reproductive biology for those who wish to pursue an academic career in research and teaching in this area of biological science. This application requests funds to continue a training grant, which has been funded for the past 25 years. Trainees will be selected based on their academic merit and potential for a productive research career in reproductive biology. The training faculty have expertise in many areas of reproductive biology including: neuroendocrine regulation of sexual development and mature reproductive function, endocrine and paracrine control of gonadal function, hormonal and growth factor regulation of the reproductive tract, hormonal control of the pituitary, photooperiodic influences on development, hormone receptors in the reproductive system, cell differentiation in early embryogenesis, hormonal control of parturition, and molecular biology of GnRH action. Many of the training faculty members have a strong molecular orientation, and virtually all have incorporated molecular techniques into their research. Predoctoral students will be trained in one of three graduate programs at the Oregon Health and Science University: Integrative Biomedical Sciences, Program in Molecular and Cellular Biology, or the Neuroscience Graduate Program. They will meet the course, seminar, and laboratory research requirements of the graduate council of OHSU and the specific requirements of the program in which they are training. Postdoctoral fellows will have access to the same courses and seminars, but emphasis will be placed on laboratory research. The unique features of this training program reside in the roster of faculty who study a wide range of areas within reproducitve biology; the close ties between the research laboratories within the training program which facilitate co-mentoring of students; free access by students to expertise and equipment in all of the laboratories of the training program; regular meetings of journal clubs and research discussion groups; and the accessibility of performing reproductive research with nonhuman primates at the Oregon National Primate Research Center, where more than half of the training faculty have either primary or secondary appointments. Programs for recruitment of minority trainees and formal instruction in the principles of scientific conduct and practice are in place in the training program. ? ?

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD007133-28
Application #
7059421
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Taymans, Susan
Project Start
1978-07-01
Project End
2009-04-30
Budget Start
2006-05-01
Budget End
2007-04-30
Support Year
28
Fiscal Year
2006
Total Cost
$199,315
Indirect Cost
Name
Oregon Health and Science University
Department
Physiology
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
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Toro, Carlos A; Wright, Hollis; Aylwin, Carlos F et al. (2018) Trithorax dependent changes in chromatin landscape at enhancer and promoter regions drive female puberty. Nat Commun 9:57
Toro, C A; Aylwin, C F; Lomniczi, A (2018) Hypothalamic epigenetics driving female puberty. J Neuroendocrinol 30:e12589
Vazquez, M J; Toro, C A; Castellano, J M et al. (2018) SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression. Nat Commun 9:4194
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Bishop, Cecily V; Xu, Fuhua; Xu, Jing et al. (2016) Western-style diet, with and without chronic androgen treatment, alters the number, structure, and function of small antral follicles in ovaries of young adult monkeys. Fertil Steril 105:1023-34
Daughtry, Brittany L; Chavez, Shawn L (2016) Chromosomal instability in mammalian pre-implantation embryos: potential causes, detection methods, and clinical consequences. Cell Tissue Res 363:201-25
Lomniczi, Alejandro; Wright, Hollis; Castellano, Juan Manuel et al. (2015) Epigenetic regulation of puberty via Zinc finger protein-mediated transcriptional repression. Nat Commun 6:10195
Rønnekleiv, Oline K; Fang, Yuan; Zhang, Chunguang et al. (2014) Research resource: Gene profiling of G protein-coupled receptors in the arcuate nucleus of the female. Mol Endocrinol 28:1362-80
McGee, W K; Bishop, C V; Pohl, C R et al. (2014) Effects of hyperandrogenemia and increased adiposity on reproductive and metabolic parameters in young adult female monkeys. Am J Physiol Endocrinol Metab 306:E1292-304

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