Abstract

This application for continued support of the University of Washington Developmental Biology Training Program will provide support for eleven graduate students for dissertation research in developmental biology. Faculty at the University of Washington and the Fred Hutchinson Cancer Research Center provide an enormous breadth of training opportunities addressing such topics as the origin of cell polarity, germ cell specification and function, body axis formation, stem cell renewal, cell differentiation, cell migration, tissue morphogenesis, metamorphosis, as well as regeneration and death. Trainees are selected from the very competitive graduate programs offered at the University of Washington. They receive in-depth instruction in topics related to developmental biology, responsible conduct of research, and development of skills for a successful career as creative and productive scientists. The program will train future scientists to address topics related to human health, including developmental defects, stem cells, and regenerative medicine. PROJECT NARRATIVE: This application for the Developmental Biology Training Program will provide support for eleven students enrolled in graduate programs at the University of Washington. The program will support dissertation research in modern developmental biology and provide training in the responsible conduct of research. The program will train future scientists to address topics related to human health, including developmental defects, stem cells, and regenerative medicine.

Public Health Relevance

This application for the Developmental Biology Training Program will provide support for eleven students enrolled in graduate programs at the University of Washington. The program will support dissertation research in modern developmental biology and provide training in the responsible conduct of research. The program will train future scientists to address topics related to human health, including developmental defects, stem cells, and regenerative medicine.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD007183-33
Application #
8462132
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Mukhopadhyay, Mahua
Project Start
1979-07-01
Project End
2016-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
33
Fiscal Year
2013
Total Cost
$401,116
Indirect Cost
$23,524

  Institution

Name
University of Washington
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Kidwell, Chelsea U; Su, Chen-Ying; Hibi, Masahiko et al. (2018) Multiple zebrafish atoh1 genes specify a diversity of neuronal types in the zebrafish cerebellum. Dev Biol 438:44-56
Seo, Aaron; Ben-Harosh, Miri; Sirin, Mehtap et al. (2017) Bone marrow failure unresponsive to bone marrow transplant is caused by mutations in thrombopoietin. Blood 130:875-880
Goralogia, Greg S; Liu, Tong-Kun; Zhao, Lin et al. (2017) CYCLING DOF FACTOR 1 represses transcription through the TOPLESS co-repressor to control photoperiodic flowering in Arabidopsis. Plant J 92:244-262
Jossin, Yves; Lee, Minhui; Klezovitch, Olga et al. (2017) Llgl1 Connects Cell Polarity with Cell-Cell Adhesion in Embryonic Neural Stem Cells. Dev Cell 41:481-495.e5
D'Orazi, Florence D; Zhao, Xiao-Feng; Wong, Rachel O et al. (2016) Mismatch of Synaptic Patterns between Neurons Produced in Regeneration and during Development of the Vertebrate Retina. Curr Biol 26:2268-79
Suli, Arminda; Pujol, Remy; Cunningham, Dale E et al. (2016) Innervation regulates synaptic ribbons in lateral line mechanosensory hair cells. J Cell Sci 129:2250-60
Davey, Crystal F; Mathewson, Andrew W; Moens, Cecilia B (2016) PCP Signaling between Migrating Neurons and their Planar-Polarized Neuroepithelial Environment Controls Filopodial Dynamics and Directional Migration. PLoS Genet 12:e1005934
Yoshimatsu, Takeshi; D'Orazi, Florence D; Gamlin, Clare R et al. (2016) Presynaptic partner selection during retinal circuit reassembly varies with timing of neuronal regeneration in vivo. Nat Commun 7:10590
Seo, Aaron; Walsh, Tom; Lee, Ming K et al. (2016) FAM111B Mutation Is Associated With Inherited Exocrine Pancreatic Dysfunction. Pancreas 45:858-62
Carlson, Keisha D; Sudmant, Peter H; Press, Maximilian O et al. (2015) Corrigendum: MIPSTR: a method for multiplex genotyping of germline and somatic STR variation across many individuals. Genome Res 25:1244

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