The primary goal of this Training Program is to develop academic leaders among Neonatologists, Maternal- Fetal Medicine (MFM) Specialists, and Basic Scientists who know how to work together collaboratively and have the capacity, based on personal meritorious accomplishments in research, to identify, understand, and solve important problems in perinatal biology and medicine. This training program provides basic and clinical- translational research training, including concepts and techniques in perinatal/developmental physiology, biochemistry, and cell and molecular biology. To our knowledge, ours is the only T32 Training Program designed with this focus, structure, and goal. Training is for 2-3 years in preparation for academic careers in departments of Pediatrics and Obstetrics & Gynecology or in basic science departments with direct links to the clinical departments. Trainees will be appointed after demonstrating research commitment and accomplishment during their late 1st or 2nd yr. of fellowship/postdoctoral training, which can be supplemented by 4th and/or 5th years of training as Fellow/Instructors. During their 1st T32 program year, trainees work with faculty advisors to select research projects and mentors. Research mentors, projects, and labs are selected among current T32 faculty, but can include the breadth of faculty and research opportunities and facilities on the UC Anschutz Medical Campus. Each area includes clinical-translational, whole animal, organ, cell, and molecular research so that a trainee can participate at one or several levels of biological investigation. Trainees attend seminars that review intrauterine development and fetal, maternal, and neonatal physiology. Courses dealing with cell culture, genetics, developmental biology, cell and molecular biology, isotope applications, biostatistics, data processing and informatics, graphics and imaging, and bioethics are included. Formal training in Responsible Conduct of Research and the value of Diversity is required. Seminar programs in research design, abstract and manuscript preparation, and grant writing are provided. The 2nd and 3rd yrs. are devoted to the completion of the research projects, further career development education and training, and expansion into new areas of research and new research techniques as appropriate. Each trainee develops institutional animal and/or clinical research protocols to address technical and ethical issues involved in animal and/or human research. Trainees plan and conduct their research projects as independently as they can, but with full faculty mentoring. This program provides multidisciplinary training in basic and clinical-translational biological investigation, integrating state-of-the-art research techniques with important questions in perinatal medicine and biology. This approach equips the trainees with the capacity to move more successfully into academic careers in either basic or clinical-translational science. Over many years, graduates of this training program have achieved high academic positions nationally and internationally and have had major impact on developing and supporting research training programs. Attaining such ultimate research/academic leadership among our trainees is a major aim of this program.

Public Health Relevance

The primary purpose of this Training Program is to develop academic leaders among Neonatologists, Maternal- Fetal Medicine (MFM) Specialists, and Basic Scientists who know how to work together collaboratively and who have the capacity, based on personal meritorious accomplishment in research, to identify, understand, and solve important problems in reproductive (perinatal) biology and medicine. Research accomplishment and academic achievement are intimately intertwined goals and are fundamental and inseparable for achieving academic and research success. Through top academic leadership positions, our graduates have made major national impact on research program development and support.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD007186-37
Application #
9272920
Study Section
Special Emphasis Panel (ZHD1)
Program Officer
Raju, Tonse N
Project Start
1979-07-01
Project End
2021-04-30
Budget Start
2017-05-01
Budget End
2018-04-30
Support Year
37
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Pediatrics
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Boehmer, B H; Brown, L D; Wesolowski, S R et al. (2018) Pulsatile hyperglycemia increases insulin secretion but not pancreatic ?-cell mass in intrauterine growth-restricted fetal sheep. J Dev Orig Health Dis 9:492-499
Bourque, Stephanie L; Meier, Stephanie A; Palmer, Claire et al. (2018) A Quality Initiative for Optimal Therapeutic Hypothermia during Transport for Neonates with Neonatal Encephalopathy. Pediatr Qual Saf 3:e056
Bourque, Stephanie L; Dietz, Robert M (2018) Does late therapeutic hypothermia reduce risk of death or disability? Acta Paediatr 107:1103
Rudolph, Michael C; Jackman, Matthew R; Presby, David M et al. (2018) Low Neonatal Plasma n-6/n-3 PUFA Ratios Regulate Offspring Adipogenic Potential and Condition Adult Obesity Resistance. Diabetes 67:651-661
Checkley, L Allyson; Rudolph, Michael C; Wellberg, Elizabeth A et al. (2017) Metformin Accumulation Correlates with Organic Cation Transporter 2 Protein Expression and Predicts Mammary Tumor RegressionIn Vivo. Cancer Prev Res (Phila) 10:198-207
Soto, Susan M; Blake, Amy C; Wesolowski, Stephanie R et al. (2017) Myoblast replication is reduced in the IUGR fetus despite maintained proliferative capacity in vitro. J Endocrinol 232:475-491
Deng, Guiying; Orfila, James E; Dietz, Robert M et al. (2017) Autonomous CaMKII Activity as a Drug Target for Histological and Functional Neuroprotection after Resuscitation from Cardiac Arrest. Cell Rep 18:1109-1117
Rudolph, M C; Young, B E; Lemas, D J et al. (2017) Early infant adipose deposition is positively associated with the n-6 to n-3 fatty acid ratio in human milk independent of maternal BMI. Int J Obes (Lond) 41:510-517
Boehmer, Brit H; Limesand, Sean W; Rozance, Paul J (2017) The impact of IUGR on pancreatic islet development and ?-cell function. J Endocrinol 235:R63-R76
Barry, James S; Rozance, Paul J; Brown, Laura D et al. (2016) Increased fetal myocardial sensitivity to insulin-stimulated glucose metabolism during ovine fetal growth restriction. Exp Biol Med (Maywood) 241:839-47

Showing the most recent 10 out of 54 publications