This training program, which is located primarily at the University of Massachusetts Medical School (UMMS) in Worcester with additional mentors at the University of Massachusetts in Amherst (UMass Amherst), provides postdoctoral training in the cell and molecular biology of reproduction. A total of 3 postdoctoral trainees will be supported each year;each trainee generally enters the program with no relevant postdoctoral experience and is supported for two years, with the possibility of a third year of support. The program is interdisciplinary and draws upon faculty from the Departments of Biochemistry and Molecular Pharmacology, Cell Biology, Molecular Medicine, Pediatrics, and Physiology at UMMS and the Department of Veterinary and Animal Sciences at UMass Amherst. The 18 training faculty members are all outstanding scientists carrying out research in one or more areas of reproductive biology. UMMS and UMass Amherst have state-of-the-art research facilities and provide superb environments for postdoctoral training. The goal of the training is two-fold: 1) to develop in young scientists the ability to recognize and define questions that will illuminate fundamental issues in reproductive biology;and 2) to provide the environment and guidance needed to attain the necessary background, intellectual rigor, and analytical and technical skills to answer these questions. Trainees also are instructed in ethics and responsible conduct of research. Trainees do not have teaching duties while supported by this program. Upon completion of training, trainees should be well prepared to carry out independent research in reproductive biology in academia or industry.

Public Health Relevance

The program will help meet the national need for highly skilled young investigators who can bring state-of-the-art cell and molecular biological approaches to bear on important problems in reproductive biology. Upon completion of training, trainees will be prepared to carry out independent research in areas relevant to contraception, infertility, and inherited and acquired diseases that affect development and the reproductive system. Scientists also will be trained to help realize the great promise of human embryonic stem cells for cell-based therapies.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
2T32HD007439-17A2
Application #
8078679
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Taymans, Susan
Project Start
1993-07-01
Project End
2016-04-30
Budget Start
2011-05-01
Budget End
2012-04-30
Support Year
17
Fiscal Year
2011
Total Cost
$101,187
Indirect Cost
Name
University of Massachusetts Medical School Worcester
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
603847393
City
Worcester
State
MA
Country
United States
Zip Code
01655
Sharma, Upasna; Conine, Colin C; Shea, Jeremy M et al. (2016) Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals. Science 351:391-396
Ivshina, Maria; Alexandrov, Ilya M; Vertii, Anastassiia et al. (2015) CPEB regulation of TAK1 synthesis mediates cytokine production and the inflammatory immune response. Mol Cell Biol 35:610-8
Shea, Jeremy M; Serra, Ryan W; Carone, Benjamin R et al. (2015) Genetic and Epigenetic Variation, but Not Diet, Shape the Sperm Methylome. Dev Cell 35:750-8
Hainer, Sarah J; Gu, Weifeng; Carone, Benjamin R et al. (2015) Suppression of pervasive noncoding transcription in embryonic stem cells by esBAF. Genes Dev 29:362-78
Carone, Benjamin R; Hung, Jui-Hung; Hainer, Sarah J et al. (2014) High-resolution mapping of chromatin packaging in mouse embryonic stem cells and sperm. Dev Cell 30:11-22
Carone, Benjamin R; Xu, Tao; Murphy, Kenan C et al. (2014) High incidence of multiple antibiotic resistant cells in cultures of in enterohemorrhagic Escherichia coli O157:H7. Mutat Res 759:1-8
Craige, Branch; Witman, George B (2014) Flipping a phosphate switch on kinesin-II to turn IFT around. Dev Cell 30:492-3
Carone, Dawn M; Zhang, Chu; Hall, Laura E et al. (2013) Hypermorphic expression of centromeric retroelement-encoded small RNAs impairs CENP-A loading. Chromosome Res 21:49-62
Jiang, Jun; Jing, Yuanchun; Cost, Gregory J et al. (2013) Translating dosage compensation to trisomy 21. Nature 500:296-300
Alexandrov, Ilya M; Ivshina, Maria; Jung, Dae Young et al. (2012) Cytoplasmic polyadenylation element binding protein deficiency stimulates PTEN and Stat3 mRNA translation and induces hepatic insulin resistance. PLoS Genet 8:e1002457

Showing the most recent 10 out of 12 publications